1,3-DI-O-TOLYLGUANIDINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C15H17N3
Molecular Weight	239.3156
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

SMILES

CC1=C(NC(=N)NC2=C(C)C=CC=C2)C=CC=C1

InChI

InChIKey=OPNUROKCUBTKLF-UHFFFAOYSA-N

InChI=1S/C15H17N3/c1-11-7-3-5-9-13(11)17-15(16)18-14-10-6-4-8-12(14)2/h3-10H,1-2H3,(H3,16,17,18)

HIDE SMILES / InChI

Molecular Formula	C15H17N3
Molecular Weight	239.3156
Charge	0
Count	MOL RATIO 1 MOL RATIO (average)

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

Targets

Targets

Primary Target	Pharmacology	Condition	Potency
Sigma opioid receptor 63	Agonist 2,678		107.0 nM [Ki]

PubMed

Show entries

Title	Date	PubMed
BMY-14802 reversed the sigma receptor agonist-induced neck dystonia in rats.	1996	9013402
Cocaine increases the endothelial release of immunoreactive endothelin and its concentrations in human plasma and urine: reversal by coincubation with sigma-receptor antagonists.	1998 Aug 4	9714087
Intrastriatal administration of sigma ligands inhibits basal dopamine release in vivo.	2003 Dec	14573387
Age-related changes of the binding of [3h]SA4503 to sigma1 receptors in the rat brain.	2003 Feb	12691135
Protein kinase C-dependent potentiation of intracellular calcium influx by sigma1 receptor agonists in rat hippocampal neurons.	2003 Nov	12975497

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Patents

Substance Class	Chemical
Record UNII	LL2P01I17O
Record Status	`Validated (UNII)`
Record Version

Show entries

Name

Type

Language

1,3-DI-O-TOLYLGUANIDINE

Common Name

English

VULCAFOR DOTG

Common Name

English

DOTG

Common Name

English

GUANIDINE, 1,3-DI-O-TOLYL-

Common Name

English

GUANIDINE, N,N'-BIS(2-METHYLPHENYL)-

Systematic Name

English

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Code System

Code

Type

Description

CAS

97-39-2

PRIMARY

NSC

473

PRIMARY

PUBCHEM

7333

PRIMARY

ECHA (EC/EINECS)

202-577-6

PRIMARY

FDA UNII

LL2P01I17O

PRIMARY

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Related Record

Type

Details


					2697FE170P

1,3-DI-O-TOLYLGUANIDINE DIPYROCATECHOL BORATE

SALT/SOLVATE -> PARENT

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