1,3-DI-O-TOLYLGUANIDINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C15H17N3
Molecular Weight	239.3156
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC1=C(NC(=N)NC2=C(C)C=CC=C2)C=CC=C1

InChI

InChIKey=OPNUROKCUBTKLF-UHFFFAOYSA-N

InChI=1S/C15H17N3/c1-11-7-3-5-9-13(11)17-15(16)18-14-10-6-4-8-12(14)2/h3-10H,1-2H3,(H3,16,17,18)

HIDE SMILES / InChI

Molecular Formula	C15H17N3
Molecular Weight	239.3156
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Sigma opioid receptor 63 Target ID: CHEMBL287 Sources: https://www.ncbi.nlm.nih.gov/pubmed/8027978	Agonist 2678		107.0 nM [Ki]

PubMed

Title	Date	PubMed
Biperiden hydrochlorate ameliorates dystonia of rats produced by microinjection of sigma ligands into the red nucleus.	2000 Nov	11164078
Effects of AH-9700, (+)-pentazocine, DTG and oxybutynin on micturition in anesthetized rats with acetone-induced cystitis.	2001 Aug 24	11589509
Evidence for sigma-1-like receptors in isolated rat liver mitochondrial membranes.	2002 Apr	11934800
Sigma receptors inhibit high-voltage-activated calcium channels in rat sympathetic and parasympathetic neurons.	2002 Jun	12037190
Age-related changes of the binding of [3h]SA4503 to sigma1 receptors in the rat brain.	2003 Feb	12691135
Antiproliferative and cytotoxic effects of some sigma2 agonists and sigma1 antagonists in tumour cell lines.	2004 Aug	15322732
Sigma-2 receptors are specifically localized to lipid rafts in rat liver membranes.	2004 Jun 16	15189760
Reproductive and developmental toxicity screening test of basic rubber accelerator, 1,3-di-o-tolylguanidine, in rats.	2006 Jul	16378712
Dermal absorption of aromatic amines in workers with different skin lesions: a report on 4 cases.	2006 Jul 19	16854230
Prenatal developmental toxicity study of the basic rubber accelerator, 1,3-di-o-tolylguanidine, in rats.	2006 Nov	16806806

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 17:57:15 UTC 2023` Edited by `admin` on `Fri Dec 15 17:57:15 UTC 2023`
Record UNII	LL2P01I17O
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

1,3-DI-O-TOLYLGUANIDINE

Common Name

English

VULCAFOR DOTG

Common Name

English

DOTG

Common Name

English

GUANIDINE, 1,3-DI-O-TOLYL-

Common Name

English

GUANIDINE, N,N'-BIS(2-METHYLPHENYL)-

Systematic Name

English

NOCCELER DT

Common Name

English

EVEITE DOTG

Common Name

English

SOXINOL DT

Common Name

English

SANCELER DT

Common Name

English

N,N'-DI-O-TOLYLGUANIDINE

Common Name

English

AKROCHEM DOTG

Common Name

English

1,3-DI-2-TOLYLGUANIDINE

Systematic Name

English

DI-O-TOLYLGUANIDINE

Common Name

English

VULKACIT DOTG

Common Name

English

1,3-BIS(O-TOLYL)GUANIDINE

Common Name

English

N,N'-BIS(2-METHYLPHENYL)GUANIDINE [HSDB]

Common Name

English

NSC-132023

Code

English

N,N'-BIS(2-METHYLPHENYL)GUANIDINE

Systematic Name

English

NSC-473

Code

English

RHENOGRAN DOTG 70

Common Name

English

Code System Code Type Description

CAS

97-39-2