1,3-DI-O-TOLYLGUANIDINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C15H17N3
Molecular Weight	239.3156
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC1=C(NC(=N)NC2=C(C)C=CC=C2)C=CC=C1

InChI

InChIKey=OPNUROKCUBTKLF-UHFFFAOYSA-N

InChI=1S/C15H17N3/c1-11-7-3-5-9-13(11)17-15(16)18-14-10-6-4-8-12(14)2/h3-10H,1-2H3,(H3,16,17,18)

HIDE SMILES / InChI

Molecular Formula	C15H17N3
Molecular Weight	239.3156
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Sigma opioid receptor 63 Target ID: CHEMBL287 Sources: https://www.ncbi.nlm.nih.gov/pubmed/8027978	Agonist 2678		107.0 nM [Ki]

PubMed

Title	Date	PubMed
Cocaine increases the endothelial release of immunoreactive endothelin and its concentrations in human plasma and urine: reversal by coincubation with sigma-receptor antagonists.	1998 Aug 4	9714087
Effect of sigma ligands on the cocaine-induced convulsions in mice.	1999 Nov-Dec	10817525
Biperiden hydrochlorate ameliorates dystonia of rats produced by microinjection of sigma ligands into the red nucleus.	2000 Nov	11164078
Effects of AH-9700, (+)-pentazocine, DTG and oxybutynin on micturition in anesthetized rats with acetone-induced cystitis.	2001 Aug 24	11589509
Pharmacology of [3H]R(+)-7-OH-DPAT binding in the rat caudate-putamen.	2001 Jan	10913686
N-alkyl substituted analogs of the sigma receptor ligand BD1008 and traditional sigma receptor ligands affect cocaine-induced convulsions and lethality in mice.	2001 Jan 12	11164383
Pharmacological actions of AH-9700 on micturition reflex in anesthetized rats.	2001 Jan 26	11165228
Agmatine and putrescine uptake in the human glioma cell line SK-MG-1.	2001 Jun	11414662
Conformationally restricted analogs of BD1008 and an antisense oligodeoxynucleotide targeting sigma1 receptors produce anti-cocaine effects in mice.	2001 May 11	11426838
Novel spiropiperidines as highly potent and subtype selective sigma-receptor ligands. Part 1.	2002 Jan 17	11784148
Identification and pharmacological characterization of a specific agmatine transport system in human tumor cell lines.	2003 Dec	15028572
Intrastriatal administration of sigma ligands inhibits basal dopamine release in vivo.	2003 Dec	14573387
Protein kinase C-dependent potentiation of intracellular calcium influx by sigma1 receptor agonists in rat hippocampal neurons.	2003 Nov	12975497
Sigma1 receptor antagonists attenuate antidepressant-like effect induced by co-administration of 1,3 di-o-tolylguanidine (DTG) and memantine in the forced swimming test in rats.	2003 Nov-Dec	14730114
Sigma-1 receptor activation prevents intracellular calcium dysregulation in cortical neurons during in vitro ischemia.	2006 Dec	16988055
Prenatal developmental toxicity study of the basic rubber accelerator, 1,3-di-o-tolylguanidine, in rats.	2006 Nov	16806806
sigma(2)-receptor ligand-mediated inhibition of inwardly rectifying K(+) channels in the heart.	2007 Jul	17460149
sigma-1 receptor modulation of acid-sensing ion channel a (ASIC1a) and ASIC1a-induced Ca2+ influx in rat cortical neurons.	2008 Nov	18723775

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 17:57:15 GMT 2023` Edited by `admin` on `Fri Dec 15 17:57:15 GMT 2023`
Record UNII	LL2P01I17O
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

1,3-DI-O-TOLYLGUANIDINE

Common Name

English

VULCAFOR DOTG

Common Name

English

DOTG

Common Name

English

GUANIDINE, 1,3-DI-O-TOLYL-

Common Name

English

GUANIDINE, N,N'-BIS(2-METHYLPHENYL)-

Systematic Name

English

NOCCELER DT

Common Name

English

EVEITE DOTG

Common Name

English

SOXINOL DT

Common Name

English

SANCELER DT

Common Name

English

N,N'-DI-O-TOLYLGUANIDINE

Common Name

English

AKROCHEM DOTG

Common Name

English

1,3-DI-2-TOLYLGUANIDINE

Systematic Name

English

DI-O-TOLYLGUANIDINE

Common Name

English

VULKACIT DOTG

Common Name

English

1,3-BIS(O-TOLYL)GUANIDINE

Common Name

English

N,N'-BIS(2-METHYLPHENYL)GUANIDINE [HSDB]

Common Name

English

NSC-132023

Code

English

N,N'-BIS(2-METHYLPHENYL)GUANIDINE

Systematic Name

English

NSC-473

Code

English

RHENOGRAN DOTG 70

Common Name

English

Code System Code Type Description

CAS

97-39-2