Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | Ni.2HO |
| Molecular Weight | 92.7081 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[OH-].[OH-].[Ni++]
InChI
InChIKey=BFDHFSHZJLFAMC-UHFFFAOYSA-L
InChI=1S/Ni.2H2O/h;2*1H2/q+2;;/p-2
DescriptionSources: http://www.tera.org/ART/Nickel/Ni%20main%20text.PDFhttp://nj.gov/health/eoh/rtkweb/documents/fs/1346.pdfhttp://www.espimetals.com/index.php/676-msds/nickel-fluoride/692-nickel-fluoridehttps://ntp.niehs.nih.gov/ntp/htdocs/lt_rpts/tr451.pdfhttp://nj.gov/health/eoh/rtkweb/documents/fs/1342.pdfhttp://www.tuks.nl/WFCProject/pdf/Electrodepositon_of_Nickel.pdfhttps://monographs.iarc.fr/ENG/Monographs/vol100C/mono100C-10.pdfhttps://www.ncbi.nlm.nih.gov/pubmed/27748567 | https://www.ncbi.nlm.nih.gov/pubmed/27824316Curator's Comment: description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/8187719
Sources: http://www.tera.org/ART/Nickel/Ni%20main%20text.PDFhttp://nj.gov/health/eoh/rtkweb/documents/fs/1346.pdfhttp://www.espimetals.com/index.php/676-msds/nickel-fluoride/692-nickel-fluoridehttps://ntp.niehs.nih.gov/ntp/htdocs/lt_rpts/tr451.pdfhttp://nj.gov/health/eoh/rtkweb/documents/fs/1342.pdfhttp://www.tuks.nl/WFCProject/pdf/Electrodepositon_of_Nickel.pdfhttps://monographs.iarc.fr/ENG/Monographs/vol100C/mono100C-10.pdfhttps://www.ncbi.nlm.nih.gov/pubmed/27748567 | https://www.ncbi.nlm.nih.gov/pubmed/27824316
Curator's Comment: description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/8187719
Nickel(II) chloride (NiCl2), a water soluble salt of Nickel, is a toxic and carcinogenic environmental and occupational pollutant, which has been shown to be carcinogenic to the lungs and nasal passages, in cases of long-term inhalation exposure. It was approved that NiCl2 was a potential genotoxicity caused indirect DNA damage by the production of ROS. In addition was conducted studies to evaluate the precise mechanism of Ni toxicology. And it was shown, thet NiCl2 induced and caused cell cycle G2/M phase arrest via p53-dependent pathway and generated inflammatory response by NF-κB pathway activation.
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: map04064 |
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Target ID: GO:0044839 |
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
| Primary | ECZEMOL Approved UseEczemol® is indicated for the treatment of moderate to severe eczema and atopic dermatitis. It has been found to work well with a variety of combination therapies. |
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PubMed
| Title | Date | PubMed |
|---|---|---|
| THE EFFECT OF PHYSICAL FORM OF IMPLANT ON NICKEL SULPHIDE TUMOURIGENESIS IN THE RAT. | 1963 |
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| Nickel concentration of blood and urine after oral administration. | 1981 Mar-Apr |
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| Carcinogenicity of nickel(II)hydroxides and nickel(II)sulfate in Wistar rats and its relation to the in vitro dissolution rates. | 1983 |
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| Occupational asthma from nickel sensitivity: II. Factors influencing the interaction of Ni2+, HSA, and serum antibodies with nickel related specificity. | 1984 Feb |
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| Carcinogenesis bioassays of nickel oxides and nickel-copper oxides by intramuscular administration to Fischer-344 rats. | 1990 Oct |
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| Metals and trace elements in plasma and cerebrospinal fluid in normal aging and Alzheimer's disease. | 1991 |
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| Risk assessment of nickel carcinogenicity and occupational lung cancer. | 1994 Jan |
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| Deliberations and evaluations of the approaches, endpoints and paradigms for dietary recommendations of the other trace elements. | 1996 Sep |
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| How should dietary guidance be given for mineral elements with beneficial actions or suspected of being essential? | 1996 Sep |
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| Daily intake of essential minerals and metallic micropollutants from foods in France. | 1998 Jun 30 |
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| Effects of trace metal compounds on HIV-1 reverse transcriptase: an in vitro study. | 1999 May |
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| Molecular mechanisms of nickel carcinogenesis. | 2002 Feb 28 |
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| Effect of nickel and iron co-exposure on human lung cells. | 2004 Apr 15 |
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| Highly selective biaryl cross-coupling reactions between aryl halides and aryl Grignard reagents: a new catalyst combination of N-heterocyclic carbenes and iron, cobalt, and nickel fluorides. | 2009 Aug 26 |
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| Nickel(II)-induced oxidative stress, apoptosis, G2/M arrest, and genotoxicity in normal rat kidney cells. | 2010 |
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| Exposure to nickel, chromium, or cadmium causes distinct changes in the gene expression patterns of a rat liver derived cell line. | 2011 |
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| An in vitro test to screen skin sensitizers using a stable THP-1-derived IL-8 reporter cell line, THP-G8. | 2011 Dec |
|
| Pituitary adenylate cyclase-activating peptide (PACAP) recruits low voltage-activated T-type calcium influx under acute sympathetic stimulation in mouse adrenal chromaffin cells. | 2011 Dec 9 |
|
| Effects of nickel treatment on H3K4 trimethylation and gene expression. | 2011 Mar 24 |
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| L-carnitine protects against nickel-induced neurotoxicity by maintaining mitochondrial function in Neuro-2a cells. | 2011 May 15 |
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| Activation of Akt/GSK3β and Akt/Bcl-2 signaling pathways in nickel-transformed BEAS-2B cells. | 2011 Nov |
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| Bioavailability, intracellular mobilization of nickel, and HIF-1α activation in human lung epithelial cells exposed to metallic nickel and nickel oxide nanoparticles. | 2011 Nov |
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| Nickel exposure induces oxidative damage to mitochondrial DNA in Neuro2a cells: the neuroprotective roles of melatonin. | 2011 Nov |
|
| Nickel(II) induced JNK activation-regulated mitochondria-dependent apoptotic pathway leading to cultured rat pancreatic β-cell death. | 2011 Nov 18 |
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| Ascorbate antagonizes nickel ion to regulate JMJD1A expression in kidney cancer cells. | 2012 Apr |
|
| Nickel ion inhibits nuclear factor-kappa B activity in human oral squamous cell carcinoma. | 2013 |
|
| GADD45α induction by nickel negatively regulates JNKs/p38 activation via promoting PP2Cα expression. | 2013 |
|
| L-tyrosinatonickel(II) complex: synthesis and structural, spectroscopic, magnetic, and biological properties of 2{[Ni(L-Tyr)2(bpy)]}·3H2O·CH3OH. | 2013 Apr 15 |
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| Differentiation of skin sensitizers from irritant chemicals by interleukin-1α and macrophage inflammatory protein-2 in murine keratinocytes. | 2013 Jan 10 |
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| Transition metal sensing by Toll-like receptor-4: next to nickel, cobalt and palladium are potent human dendritic cell stimulators. | 2013 Jun |
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| p53 activation by Ni(II) is a HIF-1α independent response causing caspases 9/3-mediated apoptosis in human lung cells. | 2013 Jun 15 |
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| Differential gene expression profile of the calanoid copepod, Pseudodiaptomus annandalei, in response to nickel exposure. | 2013 Mar |
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| Effect of Ni(II) on inflammatory gene expression in THP1 monocytic cells. | 2013 Mar |
|
| The toxic effects of nickel chloride on liver, erythropoiesis, and development in Wistar albino preimplanted rats can be reversed with selenium pretreatment. | 2013 May |
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| Dietary nickel chloride restrains the development of small intestine in broilers. | 2013 Nov |
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| Disturbance of aerobic metabolism accompanies neurobehavioral changes induced by nickel in mice. | 2013 Sep |
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| Nickel-induced cell death and survival pathways in cultured renal proximal tubule cells: roles of reactive oxygen species, ceramide and ABCB1. | 2014 Apr |
|
| NiCl2-down-regulated antioxidant enzyme mRNA expression causes oxidative damage in the broiler(')s kidney. | 2014 Dec |
|
| MiRNA-210 modulates a nickel-induced cellular energy metabolism shift by repressing the iron-sulfur cluster assembly proteins ISCU1/2 in Neuro-2a cells. | 2014 Feb 27 |
|
| Dietary nickel chloride induces oxidative stress, apoptosis and alters Bax/Bcl-2 and caspase-3 mRNA expression in the cecal tonsil of broilers. | 2014 Jan |
|
| Whole adult organism transcriptional profiling of acute metal exposures in male zebrafish. | 2014 Mar 10 |
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| Detoxification of rats subjected to nickel chloride by a biomaterial-based carbonated orthophosphate. | 2014 Sep |
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| The effect of divalent metal cations on zinc uptake by mouse Zrt/Irt-like protein 1 (ZIP1). | 2014 Sep 15 |
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| Novel Flower-like Nickel Sulfide as an Efficient Electrocatalyst for Non-aqueous Lithium-Air Batteries. | 2015 Dec 14 |
|
| Impact of cadmium, cobalt and nickel on sequence-specific DNA binding of p63 and p73 in vitro and in cells. | 2015 Jan 2 |
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| Innate stimulatory capacity of high molecular weight transition metals Au (gold) and Hg (mercury). | 2015 Mar |
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| Chemical allergens stimulate human epidermal keratinocytes to produce lymphangiogenic vascular endothelial growth factor. | 2015 Mar 1 |
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| Differential Toxicities of Nickel Salts to the Nematode Caenorhabditis elegans. | 2016 Aug |
|
| Involvement of L-type Ca²⁺ channel and toll-like receptor-4 in nickel-induced interleukin-8 gene expression. | 2016 Jan |
|
| The regulatory role of nickel on H3K27 demethylase JMJD3 in kidney cancer cells. | 2016 Jul |
Patents
Sample Use Guides
Less than 0.1 mg Ni/day (<0.001 mg Ni/kg/day for a 70 kg adult).
Route of Administration:
Oral
The effect of 44 different metal salts on the activity of the reverse transcriptase
(RT) of the human immunodeficiency virus was investigated in vitro. For each metal compound, at least two concentrations were tested (10^-4 M and 10^-5 M). At 100 uM and 10 uM Ni2+ inhibited the RT activity on 5% and 11% of the control, respectively.
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NCI_THESAURUS |
C44407
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C45863
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61534
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L8UW92NW6J
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1827
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235-008-5
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NICKEL(II) HYDROXIDE
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DTXSID90274011
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12054-48-7
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m7865
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PRIMARY | Merck Index |
PARENT (SALT/SOLVATE)
SUBSTANCE RECORD
