Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C22H25ClN2OS.2ClH |
| Molecular Weight | 473.887 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 1 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.Cl.OCCN1CCN(CC\C=C2/C3=C(SC4=C2C=C(Cl)C=C4)C=CC=C3)CC1
InChI
InChIKey=LPWNZMIBFHMYMX-MONHGIHASA-N
InChI=1S/C22H25ClN2OS.2ClH/c23-17-7-8-22-20(16-17)18(19-4-1-2-6-21(19)27-22)5-3-9-24-10-12-25(13-11-24)14-15-26;;/h1-2,4-8,16,26H,3,9-15H2;2*1H/b18-5+;;
trans-Clopenthixol is a typical antipsychotic drug of the thioxanthene class. Clopenthixol is composed of a mixture of cis-clopenthixol and trans-clopenthixol. The two isomers do not differ in several pharmacological properties, for instance, anti-noradrenergic effect. However, cis-clopenthixol possesses anti-dopaminergic effects, while trans-Clopenthixol not. Cis-Clopenthixol indicated for the management of the manifestations of schizophrenia and other mental illnesses with disturbances in thinking, emotional reactions and behavior.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Reversible lithium neurotoxicity at normal serum level may refer to intracranial pathology. | 1989 May |
|
| Zuclopenthixol, a combined dopamine D1/D2 antagonist, versus haloperidol, a dopamine D2 antagonist, in tardive dyskinesia. | 1991 Dec |
|
| Pro-oxidant activity of zuclopenthixol in vivo: differential effect of the drug on brain oxidative status of scopolamine-treated rats. | 2004 Aug |
|
| Fatal exertional heat stroke in a patient receiving zuclopenthixol, quetiapine and benztropine. | 2007 Fall |
|
| Comparative analysis of anti-toxoplasmic activity of antipsychotic drugs and valproate. | 2014 Mar |
Patents
| Name | Type | Language | ||
|---|---|---|---|---|
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Common Name | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
|
58045-22-0
Created by
admin on Fri Dec 15 15:26:31 GMT 2023 , Edited by admin on Fri Dec 15 15:26:31 GMT 2023
|
PRIMARY | |||
|
6446379
Created by
admin on Fri Dec 15 15:26:31 GMT 2023 , Edited by admin on Fri Dec 15 15:26:31 GMT 2023
|
PRIMARY | |||
|
DTXSID60110038
Created by
admin on Fri Dec 15 15:26:31 GMT 2023 , Edited by admin on Fri Dec 15 15:26:31 GMT 2023
|
PRIMARY | |||
|
L3KM17324B
Created by
admin on Fri Dec 15 15:26:31 GMT 2023 , Edited by admin on Fri Dec 15 15:26:31 GMT 2023
|
PRIMARY |
PARENT (SALT/SOLVATE)
SUBSTANCE RECORD
