Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C22H25ClN2OS.2ClH |
| Molecular Weight | 473.887 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 1 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.Cl.OCCN1CCN(CC\C=C2/C3=C(SC4=C2C=C(Cl)C=C4)C=CC=C3)CC1
InChI
InChIKey=LPWNZMIBFHMYMX-MONHGIHASA-N
InChI=1S/C22H25ClN2OS.2ClH/c23-17-7-8-22-20(16-17)18(19-4-1-2-6-21(19)27-22)5-3-9-24-10-12-25(13-11-24)14-15-26;;/h1-2,4-8,16,26H,3,9-15H2;2*1H/b18-5+;;
| Molecular Formula | ClH |
| Molecular Weight | 36.461 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | C22H25ClN2OS |
| Molecular Weight | 400.965 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 1 |
| Optical Activity | NONE |
trans-Clopenthixol is a typical antipsychotic drug of the thioxanthene class. Clopenthixol is composed of a mixture of cis-clopenthixol and trans-clopenthixol. The two isomers do not differ in several pharmacological properties, for instance, anti-noradrenergic effect. However, cis-clopenthixol possesses anti-dopaminergic effects, while trans-Clopenthixol not. Cis-Clopenthixol indicated for the management of the manifestations of schizophrenia and other mental illnesses with disturbances in thinking, emotional reactions and behavior.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| The bucco-linguo-masticatory syndrome as a side-effect of neuroleptics therapy. | 1967 |
|
| The antibacterial effect of selected phenothiazines and thioxanthenes on slow-growing mycobacteria. | 1986 Dec |
|
| Prolonged oculogyric crisis on addition of nifedipine to neuroleptic medication regime. | 1987 Jan |
|
| [acute dystonias in combined abuse of cocaine and neuroleptics]. | 1994 Nov 26 |
|
| [Trazodone for the treatment of behavioral and psychological symptoms of dementia (BPSD) in Alzheimer's disease: a retrospective study focused on the aggression and negativism in caregiving situations]. | 2006 Jun |
|
| Simultaneous determination of 25 common pharmaceuticals in whole blood using ultra-performance liquid chromatography-tandem mass spectrometry. | 2012 Sep |
Patents
| Substance Class |
Chemical
Created
by
admin
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Edited
Fri Dec 15 15:26:31 GMT 2023
by
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on
Fri Dec 15 15:26:31 GMT 2023
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| Record UNII |
L3KM17324B
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| Record Status |
Validated (UNII)
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DTXSID60110038
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L3KM17324B
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admin on Fri Dec 15 15:26:31 GMT 2023 , Edited by admin on Fri Dec 15 15:26:31 GMT 2023
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PARENT -> SALT/SOLVATE |
