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Details

Stereochemistry RACEMIC
Molecular Formula C16H17N3.2ClH
Molecular Weight 324.248
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of MIDAGLIZOLE DIHYDROCHLORIDE

SMILES

Cl.Cl.C(C(C1=CC=CC=C1)C2=NC=CC=C2)C3=NCCN3

InChI

InChIKey=PAKRIOPMNVCTCL-UHFFFAOYSA-N
InChI=1S/C16H17N3.2ClH/c1-2-6-13(7-3-1)14(12-16-18-10-11-19-16)15-8-4-5-9-17-15;;/h1-9,14H,10-12H2,(H,18,19);2*1H

HIDE SMILES / InChI

Description

Midaglizole (also known as DG 5128) is a α2 adrenoceptor antagonist. Daiichi Pharmaceutical developed this drug as an oral antidiabetic agent and to treat asthma. However, further study of this drug was discontinued.

Originator

Daiichi Pharmaceutical
9

Approval Year

Unknown
139,594

PubMed

Sample Use Guides

In Vivo Use Guide
Oral administration of DG-5128 (MIDAGLIZOLE) significantly (P less than .05) enhanced insulin secretion both 30 and 60 min after a mixed meal (550 kcal), with a concomitant decrease in postprandial plasma glucose levels at 60 and 120 min
Route of Administration: Oral
ACTIVE MOIETY
Structure of MIDAGLIZOLE
NIH
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