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Details

Stereochemistry RACEMIC
Molecular Formula C16H17N3.2ClH
Molecular Weight 324.248
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of MIDAGLIZOLE DIHYDROCHLORIDE

SMILES

Cl.Cl.C(C(C1=CC=CC=C1)C2=NC=CC=C2)C3=NCCN3

InChI

InChIKey=PAKRIOPMNVCTCL-UHFFFAOYSA-N
InChI=1S/C16H17N3.2ClH/c1-2-6-13(7-3-1)14(12-16-18-10-11-19-16)15-8-4-5-9-17-15;;/h1-9,14H,10-12H2,(H,18,19);2*1H

HIDE SMILES / InChI
Molecular Formula ClH
Molecular Weight 36.461
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE
Molecular Formula C16H17N3
Molecular Weight 251.3263
Charge 0
Count
Stereochemistry RACEMIC
Additional Stereochemistry No
Defined Stereocenters 0 / 1
E/Z Centers 0
Optical Activity ( + / - )

Description

Midaglizole (also known as DG 5128) is a α2 adrenoceptor antagonist. Daiichi Pharmaceutical developed this drug as an oral antidiabetic agent and to treat asthma. However, further study of this drug was discontinued.

Originator

Approval Year

Unknown
149124
PubMed

PubMed

TitleDatePubMed
Effect of an alpha 2-adrenoceptor antagonist, midaglizole, on bronchial responsiveness to histamine in patients with mild asthma.
1995
Pharmacological studies with the alpha 2-adrenoceptor antagonist midaglizole. Part I: Respiratory and cardiovascular systems.
1991-01
Metabolic fate of the oral hypoglycaemic agent, midaglizole, in rats.
1989-06

Sample Use Guides

In Vivo Use Guide
Oral administration of DG-5128 (MIDAGLIZOLE) significantly (P less than .05) enhanced insulin secretion both 30 and 60 min after a mixed meal (550 kcal), with a concomitant decrease in postprandial plasma glucose levels at 60 and 120 min
Route of Administration: Oral
Substance Class Chemical
Created
by admin
on Mon Mar 31 23:12:56 GMT 2025
Edited
by admin
on Mon Mar 31 23:12:56 GMT 2025
Record UNII
L29WU6X3A2
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
MIDAGLIZOLE DIHYDROCHLORIDE
Common Name English
DG 5128
Preferred Name English
PYRIDINE, 2-(2-(4,5-DIHYDRO-1H-IMIDAZOL-2-YL)-1-PHENYLETHYL)-, HYDROCHLORIDE (1:2)
Systematic Name English
MIDAGLIZOLE HYDROCHLORIDE [JAN]
Common Name English
Code System Code Type Description
PUBCHEM
157562
Created by admin on Mon Mar 31 23:12:56 GMT 2025 , Edited by admin on Mon Mar 31 23:12:56 GMT 2025
PRIMARY
FDA UNII
L29WU6X3A2
Created by admin on Mon Mar 31 23:12:56 GMT 2025 , Edited by admin on Mon Mar 31 23:12:56 GMT 2025
PRIMARY
EPA CompTox
DTXSID601000667
Created by admin on Mon Mar 31 23:12:56 GMT 2025 , Edited by admin on Mon Mar 31 23:12:56 GMT 2025
PRIMARY
CAS
79689-25-1
Created by admin on Mon Mar 31 23:12:56 GMT 2025 , Edited by admin on Mon Mar 31 23:12:56 GMT 2025
PRIMARY
Related Record Type Details
Structure of MIDAGLIZOLE DIHYDROCHLORIDE, (S)-
ENANTIOMER -> RACEMATE
Structure of MIDAGLIZOLE
PARENT -> SALT/SOLVATE
Structure of MIDAGLIZOLE DIHYDROCHLORIDE, (R)-
ENANTIOMER -> RACEMATE
Related Record Type Details
Structure of MIDAGLIZOLE
ACTIVE MOIETY
NIH
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