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Description
Curator's Comment: Description was created based on several sources, including https://www.drugs.com/monograph/senna.html and http://www.drugbank.ca/drugs/DB11365

Sennosides are hydroxyanthracene glycosides derived from Senna leaves. They have been used as natural, safe time-tested laxatives in traditional as well as modern systems of medicine. Sennosides (Senna) is a medication used to treat constipation and empty the large intestine before surgery. The medication is taken by mouth or via the rectum. It typically begins working in minutes when given by rectum and within twelve hours when given by mouth. It is a weaker laxative than bisacodyl or castor oil. Senna is an FDA-approved nonprescription drug for adults and children ages 2 years and older. It is also used for bowel preparation before colonoscopy and diagnostic imaging.

Originator

Curator's Comment: Senna was first used medicinally by Arabian physicians in the 9th century A.D.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
680.0 µM [IC50]
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
SENNA

Approved Use

Relieves occasional constipation (irregularity)

Launch Date

1.35483844E12
PubMed

PubMed

TitleDatePubMed
[Effects of sennosides on cellular electric activities in smooth muscle cells of guinea pig taenia coli].
1993 Sep
Patents

Patents

Sample Use Guides

Adults and children 12 years of age or older - 2 tablets once a day starting dose; 4 tablets twice a day maximal dose; children 6 to under 12 years - 1 tablet once a day starting dose; 2 tablets twice a day maximal dose; each Senna Tablet contains: Sennosides 8.6 mg / Standardized Senna Concentrate
Route of Administration: Oral
In Vitro Use Guide
Sennosides (20 mmol/l) induced spontaneous spike potentials in guinea pig taenia coli.
Name Type Language
SENNOSIDES ACIDS
Common Name English
SENNA ACUTIFOLIA ANTHRAQUINONE GLUCOSIDES
Common Name English
SENNA ALEXANDRINA ANTHRAQUINONE GLUCOSIDES INCLUDING SENNOSIDE A, SENNOSIDE B, SENNOSIDE C AND SENNOSIDE D
Common Name English
CASSIA SENNA ANTHRAQUINONE GLUCOSIDES
Common Name English
CASSIA ACUTIFOLIA ANTHRAQUINONE GLUCOSIDES
Common Name English
CASSIA ALEXANDRINA ANTHRAQUINONE GLUCOSIDES
Common Name English
CASSIA ANGUSTIFOLIA ANTHRAQUINONE GLUCOSIDES
Common Name English
SENNA ALEXANDRINA ANTHRAQUINONE GLUCOSIDES
Common Name English
Code System Code Type Description
FDA UNII
L0FN9W79U2
Created by admin on Thu Jul 06 06:48:14 UTC 2023 , Edited by admin on Thu Jul 06 06:48:14 UTC 2023
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