CEFMINOX SODIUM HEPTAHYDRATE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C16H19N7O7S3.Na.H.7H2O
Molecular Weight	667.664
Optical Activity	UNSPECIFIED
Defined Stereocenters	3 / 3
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of CEFMINOX SODIUM HEPTAHYDRATE

Structure Search

SMILES

[H+].O.O.O.O.O.O.O.[Na+].[H][C@]12SCC(CSC3=NN=NN3C)=C(N1C(=O)[C@]2(NC(=O)CSC[C@@H](N)C([O-])=O)OC)C([O-])=O

InChI

InChIKey=QCIJKKRQPRMHOX-CVQRGOFGSA-M

InChI=1S/C16H21N7O7S3.Na.7H2O/c1-22-15(19-20-21-22)33-4-7-3-32-14-16(30-2,13(29)23(14)10(7)12(27)28)18-9(24)6-31-5-8(17)11(25)26;;;;;;;;/h8,14H,3-6,17H2,1-2H3,(H,18,24)(H,25,26)(H,27,28);;7*1H2/q;+1;;;;;;;/p-1/t8-,14-,16+;;;;;;;;/m1......../s1

HIDE SMILES / InChI

Description
Sources: http://cefminox-sodium.blogspot.ru/2012/05/cefminox-sodium-apollo-9191-46-950-950.html
Curator's Comment: Description was created based on several sources, including http://www.toku-e.com/Cefminox-sodium-P646.aspx and http://www.ncbi.nlm.nih.gov/pubmed/9517922

Cefminox is a broad-spectrum, bactericidal cephalosporin antibiotic. It is especially effective against Gram-negative and anaerobic bacteria. It is indicated in treatment of the following infections caused by sensitive bacteria: 1. Respiratory infections: Amygdalitis, circumtonsillar abscess, bronchitis, bronchiolitis, bronchiectasis (in fection), secondary infections of chronic respiratory diseases, pneumonia, and pulmonary suppuration; 2. Infection in urinary system: Nephropyelitis, cystitis; 3. Infections in abdominal cavity: Cholecystitis' angiocholitis'peritonitis; 4. Infections in pelvic cavity: Pelvic peritonitis, adnexitis, intrauterine infection, inflammation in pelvic dead space, and parametritis; 5. Septicaemia.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Escherichia coli growth 23 Target ID: Escherichia coli growth Sources: http://www.ncbi.nlm.nih.gov/pubmed/25672407	Inhibitor 8297
Peptidoglycan biosynthesis 20 Target ID: map00550 Sources: http://www.genome.jp/dbget-bin/www_bget?D01909+D07642	Inhibitor 8297

Conditions

Condition	Modality	Highest Phase	Product
Bronchitis 51 Sources: http://cefminox-sodium.blogspot.ru/2012/05/cefminox-sodium-apollo-9191-46-950-950.html	Curative	Preclinical	Unknown Approved Use Unknown
Pneumonia 90 Sources: http://cefminox-sodium.blogspot.ru/2012/05/cefminox-sodium-apollo-9191-46-950-950.html	Curative	Preclinical	Unknown Approved Use Unknown
Cystitis 27 Sources: http://cefminox-sodium.blogspot.ru/2012/05/cefminox-sodium-apollo-9191-46-950-950.html	Curative	Preclinical	Unknown Approved Use Unknown
Septicaemia 15 Sources: http://cefminox-sodium.blogspot.ru/2012/05/cefminox-sodium-apollo-9191-46-950-950.html	Curative	Preclinical	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed

Patents

Sample Use Guides

In Vivo Use Guide

Administration only for intravenous injection or intervenous drop injection. For intravenous injection: Cefminox sodium 1g (valence) can be dissolved in 200ml water for injection, and 5~10% glucose or 0.9% sodium chloride injection. For intervenous drop injection: Cefminox sodium 1g (valence) can be dissolved in 100~500ml 5~10% glucose or 0.9% sodium chloride injection. A drop innjection for 1~2 hours. Recommended dose for adults: 1g (valence) to be administrated twice a day; Adjusted according to the age and symptoms; In septicaemia, and refractory or severe infections, a total daily dosage of 6g (valence) is divided into 3~4 administrations. Recommended dose for children: 20mg (valence)/kg (body weight) to be administrated 3~ 4 times a day.

Route of Administration: Intravenous

In Vitro Use Guide

The MIC50 and MIC90 of cefminox against E. coli were 1.0 mg/L and 4.0 mg/L, respectively.

Name

Type

Language

CEFMINOX SODIUM HEPTAHYDRATE

Common Name

English

CEFMINOX SODIUM SALT HEPTAHYDRATE [MI]

Common Name

English

MEICELIN

Brand Name

English

CEFMINOX SODIUM HYDRATE [JAN]

Common Name

English

MT-141

Code

English

5-THIA-1-AZABICYCLO(4.2.0)OCT-2-ENE-2-CARBOXYLIC ACID, 7-((2-(((2S)-2-AMINO-2-CARBOXYETHYL)THIO)ACETYL)AMINO)-7-METHOXY-3-(((1-METHYL-1H-TETRAZOL-5-YL)THIO)METHYL)-8-OXO-, SODIUM SALT, HYDRATE (1:1:7), (6R,7S)-

Systematic Name

English

Cefminox sodium hydrate [WHO-DD]

Common Name

English

CEFMINOX SODIUM SALT HEPTAHYDRATE

Common Name

English

Code System Code Type Description

SMS_ID

300000047535