U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS
This repository is under review for potential modification in compliance with Administration directives.

Details

Stereochemistry ABSOLUTE
Molecular Formula C6H12N2O4S2
Molecular Weight 240.3
Optical Activity UNSPECIFIED
Defined Stereocenters 2 / 2
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of CYSTINE, D-

SMILES

N[C@H](CSSC[C@@H](N)C(O)=O)C(O)=O

InChI

InChIKey=LEVWYRKDKASIDU-QWWZWVQMSA-N
InChI=1S/C6H12N2O4S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12)/t3-,4-/m1/s1

HIDE SMILES / InChI

Description

DL-Cystine is a racemic mixture of the proteinogenic amino acids L-cystine and the non-proteinogenic D-cystine. Cystine is the oxidized dimer form of the amino acid cysteine. L-Cystine serves two biological functions, a site of redox reactions and a mechanical linkage that allows proteins to retain their 3-dimensional structure. DL-cystine is used in the preparation of sulfur-containing dimeric and monomeric surfactants.

CNS Activity

Originator

Approval Year

Targets

Primary TargetPharmacologyConditionPotency

Conditions

ConditionModalityTargetsHighest PhaseProduct

PubMed

Sample Use Guides

In Vivo Use Guide
Unknown
Route of Administration: Unknown
In Vitro Use Guide
The study was performed with the MG 155 strain of the dermatophyte Microsporum gypseum (ATCC 26 554). For inoculum we used a suspension of spores (100/nL) released from the surface of cultures cultivated for 10 d on Sabouraud's agar (4 % glucose, 1% peptone) at 26C after shaking with glass beads. The medium contained 0.8 % glucose, 0.2 % arginine hydrochloride and 0.04 % potassium dihydrogenphosphate, and was sterilized repeatedly in a stream of steam. As a source of sulphur the basic medium A contained 1 mM sodium sulphate, medium B 3 mM L-cystine and medium C 3 mM DL-cystine. Cystine was added to the sterile medium in the form of a concentrated solution in 1 ~t hydrochloric acid and the medium was immediately neutralized with 1 M potassium hydroxide.