| Stereochemistry | ACHIRAL |
| Molecular Formula | C12H8N2.H2O |
| Molecular Weight | 198.2206 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
O.C1=CN=C2C(C=CC3=C2N=CC=C3)=C1
InChI
InChIKey=PPQJCISYYXZCAE-UHFFFAOYSA-N
InChI=1S/C12H8N2.H2O/c1-3-9-5-6-10-4-2-8-14-12(10)11(9)13-7-1;/h1-8H;1H2
o-Phenanthroline is a metal chelating agent that prevents the induction of chromosomal aberrations in streptozotocin-treated cells. Acts as a general MMP (matrix metalloproteinase) inhibitor. o-Phenanthroline has been employed as a photometric reagent for iron. o-Phenanthroline forms a complex with Fe2+, but not with Fe3+. NH2OH can be added to the solution to reduce the Fe3+ to Fe2+ for analysis of iron. Due to the o-Phenanthroline's strong UV absorbance, it may interfere with spectrophotometric assays. When complexed with copper, it possesses nuclease activity that has been employed in studying DNA-protein interactions.
Approval Year
PubMed
Patents
PARENT (SALT/SOLVATE)
SUBSTANCE RECORD
