Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C12H8N2.H2O |
| Molecular Weight | 198.2206 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
O.C1=CC2=C(N=C1)C3=C(C=CC=N3)C=C2
InChI
InChIKey=PPQJCISYYXZCAE-UHFFFAOYSA-N
InChI=1S/C12H8N2.H2O/c1-3-9-5-6-10-4-2-8-14-12(10)11(9)13-7-1;/h1-8H;1H2
| Molecular Formula | H2O |
| Molecular Weight | 18.0153 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | C12H8N2 |
| Molecular Weight | 180.2053 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
o-Phenanthroline is a metal chelating agent that prevents the induction of chromosomal aberrations in streptozotocin-treated cells. Acts as a general MMP (matrix metalloproteinase) inhibitor. o-Phenanthroline has been employed as a photometric reagent for iron. o-Phenanthroline forms a complex with Fe2+, but not with Fe3+. NH2OH can be added to the solution to reduce the Fe3+ to Fe2+ for analysis of iron. Due to the o-Phenanthroline's strong UV absorbance, it may interfere with spectrophotometric assays. When complexed with copper, it possesses nuclease activity that has been employed in studying DNA-protein interactions.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Localization of gelatinolytic activity can be detected in breast cancer tissues by film in situ zymography. | 2001 |
|
| Probing site specificity of DNA binding metallointercalators by NMR spectroscopy and molecular modeling. | 2001 Apr 17 |
|
| Synthesis of [Ru(phen)(2)dppz](2+)-tethered oligo-DNA and studies on the metallointercalation mode into the DNA duplex. | 2001 Apr 18 |
|
| Conformational isomerism and weak molecular and magnetic interactions in ternary copper(II) complexes of [Cu(AA)L']ClO4.nH2O, where AA = L-phenylalanine and L-histidine, L' = 1,10-phenanthroline and 2,2-bipyridine, and n = 1 or 1.5: synthesis, single-crystal X-ray structures, and magnetic resonance investigations. | 2001 Aug 13 |
|
| Heterobimetallic oxalato-bridged Cu(II)Re(IV) complexes. Synthesis, crystal structure and magnetic properties. | 2001 Aug 13 |
|
| Mitochondrial processing of newly synthesized steroidogenic acute regulatory protein (StAR), but not total StAR, mediates cholesterol transfer to cytochrome P450 side chain cleavage enzyme in adrenal cells. | 2001 Dec 7 |
|
| Characterization of the pro-aminopeptidase from Aeromonas caviae T-64. | 2001 Feb |
|
| Friedländer synthesis of chiral alkyl-substituted 1,10-phenanthrolines. | 2001 Jan 26 |
|
| [Study of ribosome structure using the biochemical methods: judgment day]. | 2001 Jul-Aug |
|
| Bis(4,7-dimethyl and 5-dinitro-1,10-phenanthroline) sulfato-oxovanadium(IV)-mediated in vivo male germ cell apoptosis. | 2001 Jul-Aug |
|
| Matrix metalloproteinase-2 in platelet adhesion to fibrinogen: interactions with nitric oxide. | 2001 Jul-Aug |
|
| Purification and characterization of a 43.5 kDa keratinolytic metalloprotease from Microsporum canis. | 2001 Jun |
|
| Isotachophoretic separation behavior of rare-earth EDTA chelates and analysis of minor rare-earth elements in an iron ore by bidirectional isotachophoresis-particle-induced X-ray emission. | 2001 Jun 15 |
|
| Phenanthroline-Cu(II) cleavage as a probe of rRNA structure. | 2001 Mar |
|
| In vivo assessment of endothelin-induced heterogeneity of hepatic tissue perfusion. | 2001 Mar |
|
| Phenanthrolines--a new class of CFTR chloride channel openers. | 2001 Oct |
|
| Functional expression and characterization of the cytoplasmic aminopeptidase P of Caenorhabditis elegans. | 2001 Oct |
|
| Allosteric interaction of minor groove binding ligands with UL9-DNA complexes. | 2001 Oct 23 |
|
| Use of SDS micelles to stabilize a ternary intermediate in the reaction of ferrioxamine B and 1,10-phenanthroline. | 2001 Oct 8 |
|
| Stress proteins in oligodendrocytes: differential effects of heat shock and oxidative stress. | 2001 Sep |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 04:19:11 GMT 2023
by
admin
on
Sat Dec 16 04:19:11 GMT 2023
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| Record UNII |
KSX215X00E
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| Record Status |
Validated (UNII)
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| Record Version |
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m8598
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KSX215X00E
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DTXSID6075302
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21226
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5144-89-8
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ANHYDROUS->SOLVATE |
