Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C9H8INO3 |
| Molecular Weight | 303.0693 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
OC(=O)CNC(=O)C1=CC=CC=C1[125I]
InChI
InChIKey=CORFWQGVBFFZHF-CKWBHOIGSA-N
InChI=1S/C9H8INO3/c10-7-4-2-1-3-6(7)9(14)11-5-8(12)13/h1-4H,5H2,(H,11,14)(H,12,13)/i10-2
Iodohippuric acid I-125 (I-I25 Hippuran) is radioisotope that was used as a renogram probe in nefhrography in 1960s-1970s. It is an analog of I-131 labeled I(131) hippuran which has been recognized as the radiopharmaceutical standard for the measurement of effective renal plasma flow in subjects with renal failure but which use has been compromised by the suboptimal imaging characteristics of the 364-keV photon of 131I and the delivery of relatively high radiation doses to kidneys and thyroid in patients with impaired renal function. It was shown that radiation risk was rendered to a minimum with the use of the "cocktail" of 169U-EDTA and 125I-hippuran.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| THE USE OF I-125 ORTHO-IODOHIPPURATE FOR LOCALIZING THE RADIOISOTOPE RENOGRAM PROBE. | 1965 Apr |
|
| [Determination of allyl inulin labeled with I-131 and hippuran labeled with I-125 in man]. | 1965 Jul |
|
| [Nephrography in small children with I-125-hippuran]. | 1967 |
|
| [Comparative studies with I-125 and I-131 labeled hippuran in the isotope nephrogram]. | 1967 Jan 10 |
|
| [Clinical possibilities of a method for the simultaneous determination of the GFR and the ERBF using a "cocktail" of 169 EDTA and 125I-hippuran]. | 1976 |
|
| Renographic evaluation of kidney preservation with chlorpromazine. | 1979 Jan |
Sample Use Guides
I-I25 Hippuran, 4.4 uCi was injected in rabbits rapidly intravenously, after which the renogram was followedfor 20 min
Route of Administration:
Intravenous
Hippuran uptake was measured in the rabbit left kidney cortex slices exposed to 3 hr warm ischemia in an untreated and chlorpromazine-pretreated group. The cortex was sliced manually with an ice-cooled microtome. The 0.2-mm slices were distributed evenly among eight incubation vessels. Each vessel contained 50 ml Cross-Taggarts solution including one uCi 1-125 Hippuran. The solution was oxygenated before and during the subsequent 60-min incubation at 25°C. The 1-125 Hippuran uptake was calculated as the ratio between the Hippuran content per gram of tissue over that per milliliter of incubation fluid, i.e. the slice-to-medium ratio.
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71179
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58861-30-6
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DTXSID70974360
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KQ27CMS0PY
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admin on Sat Dec 16 01:55:59 GMT 2023 , Edited by admin on Sat Dec 16 01:55:59 GMT 2023
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ACTIVE MOIETY
SALT/SOLVATE (PARENT)
