IODOHIPPURATE SODIUM I-125

Details

Stereochemistry	ACHIRAL
Molecular Formula	C9H7INO3.Na
Molecular Weight	325.0512
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[Na+].[O-]C(=O)CNC(=O)C1=CC=CC=C1[125I]

InChI

InChIKey=XYITYKDGJLHYPW-KYMMBCSGSA-M

InChI=1S/C9H8INO3.Na/c10-7-4-2-1-3-6(7)9(14)11-5-8(12)13;/h1-4H,5H2,(H,11,14)(H,12,13);/q;+1/p-1/i10-2;

HIDE SMILES / InChI

Molecular Formula	Na
Molecular Weight	22.9898
Charge	1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C9H7INO3
Molecular Weight	302.0614
Charge	-1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/14276211 | https://www.ncbi.nlm.nih.gov/pubmed/430173 | https://www.ncbi.nlm.nih.gov/pubmed/6078408 | https://www.ncbi.nlm.nih.gov/pubmed/19808227 | https://www.ncbi.nlm.nih.gov/pubmed/23424193 | https://www.ncbi.nlm.nih.gov/pubmed/?term=827856

Iodohippuric acid I-125 (I-I25 Hippuran) is radioisotope that was used as a renogram probe in nefhrography in 1960s-1970s. It is an analog of I-131 labeled I(131) hippuran which has been recognized as the radiopharmaceutical standard for the measurement of effective renal plasma flow in subjects with renal failure but which use has been compromised by the suboptimal imaging characteristics of the 364-keV photon of 131I and the delivery of relatively high radiation doses to kidneys and thyroid in patients with impaired renal function. It was shown that radiation risk was rendered to a minimum with the use of the "cocktail" of 169U-EDTA and 125I-hippuran.

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Kidney disease 6 Sources: https://www.ncbi.nlm.nih.gov/pubmed/6078408 https://www.ncbi.nlm.nih.gov/pubmed/827856	Diagnostic		Not Provided 504	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
THE USE OF I-125 ORTHO-IODOHIPPURATE FOR LOCALIZING THE RADIOISOTOPE RENOGRAM PROBE.	1965 Apr	14276211
[Determination of allyl inulin labeled with I-131 and hippuran labeled with I-125 in man].	1965 Jul	5891490
[Nephrography in small children with I-125-hippuran].	1967	6078408
[Comparative studies with I-125 and I-131 labeled hippuran in the isotope nephrogram].	1967 Jan 10	5631681
[Clinical possibilities of a method for the simultaneous determination of the GFR and the ERBF using a "cocktail" of 169 EDTA and 125I-hippuran].	1976	827856
Renographic evaluation of kidney preservation with chlorpromazine.	1979 Jan	430173

Sample Use Guides

In Vivo Use Guide

I-I25 Hippuran, 4.4 uCi was injected in rabbits rapidly intravenously, after which the renogram was followedfor 20 min

Route of Administration: Intravenous

In Vitro Use Guide

Hippuran uptake was measured in the rabbit left kidney cortex slices exposed to 3 hr warm ischemia in an untreated and chlorpromazine-pretreated group. The cortex was sliced manually with an ice-cooled microtome. The 0.2-mm slices were distributed evenly among eight incubation vessels. Each vessel contained 50 ml Cross-Taggarts solution including one uCi 1-125 Hippuran. The solution was oxygenated before and during the subsequent 60-min incubation at 25°C. The 1-125 Hippuran uptake was calculated as the ratio between the Hippuran content per gram of tissue over that per milliliter of incubation fluid, i.e. the slice-to-medium ratio.

Substance Class	Chemical Created by `admin` on `Fri Dec 15 14:57:33 GMT 2023` Edited by `admin` on `Fri Dec 15 14:57:33 GMT 2023`
Record UNII	T5536Q4O60
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

IODOHIPPURATE SODIUM I-125

Common Name

English

SODIUM IODOHIPPURATE (125 I)

Common Name

English

GLYCINE, N-(2-(IODO-(SUP 125)I)BENZOYL)-, MONOSODIUM SALT

Common Name

English

IODOHIPPURATE SODIUM, I-125

Common Name

English

HIPPPUTOPE I-125

Brand Name

English

GLYCINE, N-(2-(IODO-(SUP 125)I)BENZOYL)-,MONOSODIUM SALT

Common Name

English

IODOHIPPURATE SODIUM I 125

Official Name

English

SODIUM IODOHIPPURATE I-125

Common Name

English

IODOHIPPURATE SODIUM I 125 [USAN]

Common Name

English

Sodium iodohippurate (125 i) [WHO-DD]

Common Name

English

MONOSODIUM O-IODO-(SUP 125)I-HIPPURATE

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C2124