ADINAZOLAM

Details

Stereochemistry	ACHIRAL
Molecular Formula	C19H18ClN5
Molecular Weight	351.833
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CN(C)CC1=NN=C2CN=C(C3=CC=CC=C3)C4=C(C=CC(Cl)=C4)N12

InChI

InChIKey=GJSLOMWRLALDCT-UHFFFAOYSA-N

InChI=1S/C19H18ClN5/c1-24(2)12-18-23-22-17-11-21-19(13-6-4-3-5-7-13)15-10-14(20)8-9-16(15)25(17)18/h3-10H,11-12H2,1-2H3

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/6320036 | https://www.ncbi.nlm.nih.gov/pubmed/3298327 | https://www.ncbi.nlm.nih.gov/pubmed/9600717 | https://www.ncbi.nlm.nih.gov/pubmed/27535017

Adinazolam, a benzodiazepine agonist, is an effective anxiolytic agent with antidepressant properties. It was shown, that adinazolam by itself had relatively weak benzodiazepine agonist activity, and much of the pharmacological activity belonged to its active metabolite N-desmethyladinazolam (NDMAD). Adinazolam has never been FDA approved, but it is sold as a research chemical.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
GABA-A receptor; benzodiazepine site 38 Target ID: CHEMBL2109243 Sources: https://www.ncbi.nlm.nih.gov/pubmed/6148400	Agonist 2678

PubMed

Title	Date	PubMed
Flumazenil prevents the anxiolytic effects of diazepam, alprazolam and adinazolam on the early acquisition of two-way active avoidance.	1993 Jul-Aug	8234145
Kinetic characterization and identification of the enzymes responsible for the hepatic biotransformation of adinazolam and N-desmethyladinazolam in man.	1998 Mar	9600717
The effect of sympathetic antagonists on the antidepressant action of alprazolam.	2008 Jun 1	21499463
Recent trends in the impurity profile of pharmaceuticals.	2010 Jul	22247862

Patents

Sample Use Guides

In Vivo Use Guide

from 90 to 40 mg/day.

Route of Administration: Oral

Name

Type

Language

ADINAZOLAM

Official Name

English

ADINAZOLAM [MI]

Common Name

English

U-41,123

Code

English

Adinazolam [WHO-DD]

Common Name

English

4H-(1,2,4)TRIAZOLO(4,3-A)(1,4)BENZODIAZEPINE-1-METHANAMINE, 8-CHLORO-N-N-DIMETHYL-6-PHENYL-

Common Name

English

U-41123

Code

English

adinazolam [INN]

Common Name

English

8-Chloro-1-[(dimethylamino)methyl]-6-phenyl-4H-S-triazolo[4,3-a][1,4]benzodiazepine

Systematic Name

English

ADINAZOLAM [USAN]

Common Name

English

Classification Tree Code System Code

WHO-VATC

QN05BA07