ROBINETIN

Details

Stereochemistry	ACHIRAL
Molecular Formula	C15H10O7
Molecular Weight	302.2357
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

SMILES

OC1=CC2=C(C=C1)C(=O)C(O)=C(O2)C3=CC(O)=C(O)C(O)=C3

InChI

InChIKey=SOEDEYVDCDYMMH-UHFFFAOYSA-N

InChI=1S/C15H10O7/c16-7-1-2-8-11(5-7)22-15(14(21)12(8)19)6-3-9(17)13(20)10(18)4-6/h1-5,16-18,20-21H

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Description

Robinetin is a bioactive plant flavonol. Robinetin inhibited the mutagenic activity resulting from the metabolic activation of benzo[a]-pyrene and (+/-)-trans-7,8-dihydroxy-7,8-dihydrobenzo[a]-pyrene by rat liver microsomes.

Approval Year

Targets

Primary Target	Pharmacology	Potency
Ornithine decarboxylase 15	Modulator 846
Mitochondrial complex I (NADH dehydrogenase) 11	Inhibitor 8,504
Multidrug resistance-associated protein 1 15	Inhibitor 8,504	5.0 µM [Ki]

Conditions

Condition	Modality	Targets	Highest Phase	Product
Cancer 609	Primary		Preclinical	Unknown

PubMed

Show entries

Title	Date	PubMed
Application of the electrotopological state index to QSAR analysis of flavone derivatives as HIV-1 integrase inhibitors.	1996 Dec	8987091
Study of freeze-dried quercetin-cyclodextrin binary systems by DSC, FT-IR, X-ray diffraction and SEM analysis.	2004 Feb 4	15013147
Binding of the bioflavonoid robinetin with model membranes and hemoglobin: Inhibition of lipid peroxidation and protein glycosylation.	2010 Jan 21	19914085

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Patents

Sample Use Guides

In Vivo Use Guide

Examination of both urine extracts from robinetin-fed rats (200mg/rat) and ether extracts ofrobinetin incubation mixtures (10mg/tube) revealed the presence of large amounts of unchanged robinetin.

Route of Administration: Oral

In Vitro Use Guide

Robinetin inhibited MRP2 activity more than 50% at 25 uM concentration.

Show entries

Name

Type

Language

NSC-407331

Preferred Name

English

ROBINETIN

Common Name

English

3,7,3',4',5'-PENTAHYDROXYFLAVONE

Systematic Name

English

FLAVONE, 3,3',4',5',7-PENTAHYDROXY-

Systematic Name

English

NORKANUGIN

Common Name

English

Showing 1 to 5 of 10 entries

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Code System

Code

Type

Description

EPA CompTox

DTXSID30197654

PRIMARY

FDA UNII

KJ6DBC4U7E

PRIMARY

NSC

407331

PRIMARY

PUBCHEM

5281692

PRIMARY

ECHA (EC/EINECS)

207-709-6

PRIMARY

Showing 1 to 5 of 8 entries

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SUBSTANCE RECORD


					KJ6DBC4U7E

ROBINETIN