U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry RACEMIC
Molecular Formula C18H19NO3
Molecular Weight 297.3484
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of GLAZIOVINE

SMILES

COC1=CC2=C3C(CC4(C=CC(=O)C=C4)C3=C1O)N(C)CC2

InChI

InChIKey=PNJUPRNTSWJWAX-UHFFFAOYSA-N
InChI=1S/C18H19NO3/c1-19-8-5-11-9-14(22-2)17(21)16-15(11)13(19)10-18(16)6-3-12(20)4-7-18/h3-4,6-7,9,13,21H,5,8,10H2,1-2H3

HIDE SMILES / InChI

Description

Glaziovine is a pro-aporphine alkaloid with neuropharmacological properties. Glaziovine is an alkaloid, originally isolated from Ocotea glaziovii (Lauraceae), belonging to the fairly small proaporphine family. In the early 1970's its pharmacology was explored extensively by a pharmaceutical company (Simes S.p.A., Milano), and was registered as a tranquilizer under the trademark Suavedol®. It is also reported to possess anti-ulcer properties in humans.

CNS Activity

Originator

Approval Year

Unknown
139594
Targets

Targets

Primary TargetPharmacologyConditionPotency
Inhibitor
8297
 0.008 mM [IC50]
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Preclinical
Unknown

Approved Use

Unknown
Primary
Phase I
428
Unknown

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
Antiplatelet aggregation constituents from Annona purpurea.
1998 Dec
Two new alkaloids and active anti-hepatitis B virus constituents from Hypserpa nitida.
2007 Oct 1
Alkaloids from Cinnamomum philippinense.
2012 Dec
Patents

Patents

US2002102215
1
US6261537
11
US6264917
2

Sample Use Guides

In Vivo Use Guide
Glaziovine-14C 20 mg was administered in capsules (oral route) and in vials (i.v. route).
Route of Administration: Other
In Vitro Use Guide
Glaziovine exhibits high inhibitory potential against HBsAg with IC50 value of 0.008 mM.
Name Type Language
GLAZIOVINE
INN  
INN  
Official Name English
NSC-146052
Code English
glaziovine [INN]
Common Name English
(±)-GLAZIOVINE
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C29701
Created by admin on Fri Dec 15 16:00:37 GMT 2023 , Edited by admin on Fri Dec 15 16:00:37 GMT 2023
Code System Code Type Description
MESH
C007847
Created by admin on Fri Dec 15 16:00:37 GMT 2023 , Edited by admin on Fri Dec 15 16:00:37 GMT 2023
PRIMARY
FDA UNII
KE7J8A65P6
Created by admin on Fri Dec 15 16:00:37 GMT 2023 , Edited by admin on Fri Dec 15 16:00:37 GMT 2023
PRIMARY
NCI_THESAURUS
C73193
Created by admin on Fri Dec 15 16:00:37 GMT 2023 , Edited by admin on Fri Dec 15 16:00:37 GMT 2023
PRIMARY
INN
3831
Created by admin on Fri Dec 15 16:00:37 GMT 2023 , Edited by admin on Fri Dec 15 16:00:37 GMT 2023
PRIMARY
PUBCHEM
65631
Created by admin on Fri Dec 15 16:00:37 GMT 2023 , Edited by admin on Fri Dec 15 16:00:37 GMT 2023
PRIMARY
SMS_ID
100000080420
Created by admin on Fri Dec 15 16:00:37 GMT 2023 , Edited by admin on Fri Dec 15 16:00:37 GMT 2023
PRIMARY
CAS
17127-48-9
Created by admin on Fri Dec 15 16:00:37 GMT 2023 , Edited by admin on Fri Dec 15 16:00:37 GMT 2023
PRIMARY
ChEMBL
CHEMBL1980854
Created by admin on Fri Dec 15 16:00:37 GMT 2023 , Edited by admin on Fri Dec 15 16:00:37 GMT 2023
PRIMARY
EPA CompTox
DTXSID90864739
Created by admin on Fri Dec 15 16:00:37 GMT 2023 , Edited by admin on Fri Dec 15 16:00:37 GMT 2023
PRIMARY
NSC
146052
Created by admin on Fri Dec 15 16:00:37 GMT 2023 , Edited by admin on Fri Dec 15 16:00:37 GMT 2023
PRIMARY
EVMPD
SUB07911MIG
Created by admin on Fri Dec 15 16:00:37 GMT 2023 , Edited by admin on Fri Dec 15 16:00:37 GMT 2023
PRIMARY
ACTIVE MOIETY
Structure of GLAZIOVINE
NIH
NCATS
PRIVACY ACT
ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
For language access assistance, contact the NCATS Public Information Officer
National Center for Advancing Translational Sciences (NCATS),
6701 Democracy Boulevard, Bethesda MD 20892-4874 • 301-594-8966