Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C19H21ClN5O5P |
| Molecular Weight | 465.827 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
COC1=C(C)C=NC(CN2C=C(C#CCCOP(O)(O)=O)C3=C(Cl)N=C(N)N=C23)=C1C
InChI
InChIKey=BMZGPNGECPQAGB-UHFFFAOYSA-N
InChI=1S/C19H21ClN5O5P/c1-11-8-22-14(12(2)16(11)29-3)10-25-9-13(6-4-5-7-30-31(26,27)28)15-17(20)23-19(21)24-18(15)25/h8-9H,5,7,10H2,1-3H3,(H2,21,23,24)(H2,26,27,28)
Approval Year
| Name | Type | Language | ||
|---|---|---|---|---|
|
Common Name | English | ||
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Systematic Name | English | ||
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Code | English | ||
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Systematic Name | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
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C78846
Created by
admin on Sat Dec 16 11:37:18 GMT 2023 , Edited by admin on Sat Dec 16 11:37:18 GMT 2023
|
PRIMARY | |||
|
BIIB-028
Created by
admin on Sat Dec 16 11:37:18 GMT 2023 , Edited by admin on Sat Dec 16 11:37:18 GMT 2023
|
PRIMARY | Description: BIIB028 is a small-molecule inhibitor of heat shock protein (Hsp) 90 with potential antineoplastic activity. Hsp90 inhibitor BIIB028 blocks the binding of oncogenic client proteins to Hsp90, which may result in the proteasomal degradation of these proteins and so the inhibition of tumor cell proliferation. Hsp90 is a molecular chaperone that plays a key role in the conformational maturation of oncogenic signaling proteins, such as Her2/Erbb2, Akt, Raf1, Bcr-Abl, and mutated p53, in addition to other molecules involved in cell cycle regulation and immune responses. | ||
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KD4GWWK597
Created by
admin on Sat Dec 16 11:37:18 GMT 2023 , Edited by admin on Sat Dec 16 11:37:18 GMT 2023
|
PRIMARY | |||
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1315607-68-1
Created by
admin on Sat Dec 16 11:37:18 GMT 2023 , Edited by admin on Sat Dec 16 11:37:18 GMT 2023
|
NO STRUCTURE GIVEN | |||
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911398-13-5
Created by
admin on Sat Dec 16 11:37:18 GMT 2023 , Edited by admin on Sat Dec 16 11:37:18 GMT 2023
|
PRIMARY | |||
|
57713852
Created by
admin on Sat Dec 16 11:37:18 GMT 2023 , Edited by admin on Sat Dec 16 11:37:18 GMT 2023
|
PRIMARY |
ACTIVE MOIETY
