U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula C13H14O5S
Molecular Weight 282.312
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of ESUPRONE

SMILES

CCS(=O)(=O)OC1=CC2=C(C=C1)C(C)=C(C)C(=O)O2

InChI

InChIKey=CHDGAVDQRSPBTA-UHFFFAOYSA-N
InChI=1S/C13H14O5S/c1-4-19(15,16)18-10-5-6-11-8(2)9(3)13(14)17-12(11)7-10/h5-7H,4H2,1-3H3

HIDE SMILES / InChI
Esuprone (LU 43839) is a monoamine oxidase type A inhibitor. Esuprone proved to be an effective anticonvulsant in the kindling model. Esuprone was undergoing phase II clinical trials with Knoll (BASF Pharma) in Germany as an antidepressant.

Approval Year

PubMed

PubMed

TitleDatePubMed
MAO-A inhibition in brain after dosing with esuprone, moclobemide and placebo in healthy volunteers: in vivo studies with positron emission tomography.
1997
Inhibition of monoamine oxidase type A, but not type B, is an effective means of inducing anticonvulsant activity in the kindling model of epilepsy.
1999 Mar
Synthesis and study of a series of 3-arylcoumarins as potent and selective monoamine oxidase B inhibitors.
2011 Oct 27
Name Type Language
ESUPRONE
INN  
INN  
Official Name English
esuprone [INN]
Common Name English
7-HYDROXY-3,4-DIMETHYLCOUMARIN ETHANESULFONATE
Systematic Name English
Classification Tree Code System Code
NCI_THESAURUS C667
Created by admin on Sat Dec 16 17:53:20 GMT 2023 , Edited by admin on Sat Dec 16 17:53:20 GMT 2023
Code System Code Type Description
FDA UNII
K7EB9E48ZE
Created by admin on Sat Dec 16 17:53:20 GMT 2023 , Edited by admin on Sat Dec 16 17:53:20 GMT 2023
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EVMPD
SUB07252MIG
Created by admin on Sat Dec 16 17:53:20 GMT 2023 , Edited by admin on Sat Dec 16 17:53:20 GMT 2023
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WIKIPEDIA
ESUPRONE
Created by admin on Sat Dec 16 17:53:20 GMT 2023 , Edited by admin on Sat Dec 16 17:53:20 GMT 2023
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SMS_ID
100000082384
Created by admin on Sat Dec 16 17:53:20 GMT 2023 , Edited by admin on Sat Dec 16 17:53:20 GMT 2023
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CAS
91406-11-0
Created by admin on Sat Dec 16 17:53:20 GMT 2023 , Edited by admin on Sat Dec 16 17:53:20 GMT 2023
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MESH
C107376
Created by admin on Sat Dec 16 17:53:20 GMT 2023 , Edited by admin on Sat Dec 16 17:53:20 GMT 2023
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NCI_THESAURUS
C65544
Created by admin on Sat Dec 16 17:53:20 GMT 2023 , Edited by admin on Sat Dec 16 17:53:20 GMT 2023
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ChEMBL
CHEMBL18504
Created by admin on Sat Dec 16 17:53:20 GMT 2023 , Edited by admin on Sat Dec 16 17:53:20 GMT 2023
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PUBCHEM
65827
Created by admin on Sat Dec 16 17:53:20 GMT 2023 , Edited by admin on Sat Dec 16 17:53:20 GMT 2023
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EPA CompTox
DTXSID60238549
Created by admin on Sat Dec 16 17:53:20 GMT 2023 , Edited by admin on Sat Dec 16 17:53:20 GMT 2023
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INN
5848
Created by admin on Sat Dec 16 17:53:20 GMT 2023 , Edited by admin on Sat Dec 16 17:53:20 GMT 2023
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