6,7-DIMETHOXYQUINAZOLINE-2,4(1H,3H)-DIONE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C10H10N2O4
Molecular Weight	222.1974
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of 6,7-DIMETHOXYQUINAZOLINE-2,4(1H,3H)-DIONE

SMILES

COC1=CC2=C(C=C1OC)C(=O)NC(=O)N2

InChI

InChIKey=KWNQIIMVPSMYEM-UHFFFAOYSA-N

InChI=1S/C10H10N2O4/c1-15-7-3-5-6(4-8(7)16-2)11-10(14)12-9(5)13/h3-4H,1-2H3,(H2,11,12,13,14)

HIDE SMILES / InChI

Description

6,7-dimethoxyquinazoline-2,4(1H,3H)-dione is useful as a building block in the synthesis of alpha adrenergic receptor antagonists such as Prazosin, Bunazosin and Doxazosin, and which are useful as antihypertensive agents.

Approval Year

Conditions

Conditions

Condition	Modality	Targets	Highest Phase	Product
Unknown 2,578

PubMed

PubMed

Show entries

Title	Date	PubMed
A new and facile synthesis of quinazoline-2,4(1H,3H)-diones.	2009 Mar 19	19239261
Synthesis and biological activity of a novel series of 6,7-dimethoxyquinazoline-2,4(1H,3H)-dione derivatives.	2012 Jan-Feb	22574519

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Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

Unknown

Show entries

Name

Type

Language

6,7-DIMETHOXYQUINAZOLINE-2,4(1H,3H)-DIONE

Systematic Name

English

USP DOXAZOSIN RELATED COMPOUND B [USP IMPURITY]

Common Name

English

6,7-DIMETHOXY-1H-QUINAZOLINE-2,4-DIONE

Systematic Name

English

DOXAZOSIN IMPURITY D

Common Name

English

6,7-DIMETHOXYQUINAZOLINE-2,4-DIONE

Systematic Name

English

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Code System

Code

Type

Description

ECHA (EC/EINECS)

249-288-1

PRIMARY

FDA UNII

K7867Z125J

PRIMARY

PUBCHEM

120081

PRIMARY

CAS

28888-44-0

PRIMARY

EPA CompTox

DTXSID9046100

PRIMARY

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SUBSTANCE RECORD


					K7867Z125J

6,7-DIMETHOXYQUINAZOLINE-2,4(1H,3H)-DIONE