6,7-DIMETHOXYQUINAZOLINE-2,4(1H,3H)-DIONE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C10H10N2O4
Molecular Weight	222.1974
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of 6,7-DIMETHOXYQUINAZOLINE-2,4(1H,3H)-DIONE

Structure Search

SMILES

COC1=CC2=C(C=C1OC)C(=O)NC(=O)N2

InChI

InChIKey=KWNQIIMVPSMYEM-UHFFFAOYSA-N

InChI=1S/C10H10N2O4/c1-15-7-3-5-6(4-8(7)16-2)11-10(14)12-9(5)13/h3-4H,1-2H3,(H2,11,12,13,14)

HIDE SMILES / InChI

Molecular Formula	C10H10N2O4
Molecular Weight	222.1974
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: http://www.tandfonline.com/doi/abs/10.1080/17518250802331181#aHR0cDovL3d3dy50YW5kZm9ubGluZS5jb20vZG9pL3BkZi8xMC4xMDgwLzE3NTE4MjUwODAyMzMxMTgxP25lZWRBY2Nlc3M9dHJ1ZUBAQDA=

6,7-dimethoxyquinazoline-2,4(1H,3H)-dione is useful as a building block in the synthesis of alpha adrenergic receptor antagonists such as Prazosin, Bunazosin and Doxazosin, and which are useful as antihypertensive agents.

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Unknown 2578

PubMed

Title	Date	PubMed
A new and facile synthesis of quinazoline-2,4(1H,3H)-diones.	2009 Mar 19	19239261
Synthesis and biological activity of a novel series of 6,7-dimethoxyquinazoline-2,4(1H,3H)-dione derivatives.	2012 Jan-Feb	22574519

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Sat Dec 16 01:58:39 GMT 2023` Edited by `admin` on `Sat Dec 16 01:58:39 GMT 2023`
Record UNII	K7867Z125J
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

6,7-DIMETHOXYQUINAZOLINE-2,4(1H,3H)-DIONE

Systematic Name

English

USP DOXAZOSIN RELATED COMPOUND B [USP IMPURITY]

Common Name

English

6,7-DIMETHOXY-1H-QUINAZOLINE-2,4-DIONE

Systematic Name

English

DOXAZOSIN IMPURITY D

Common Name

English

6,7-DIMETHOXYQUINAZOLINE-2,4-DIONE

Systematic Name

English

2,4(1H,3H)-QUINAZOLINEDIONE, 6,7-DIMETHOXY-

Systematic Name

English

DOXAZOSIN MESILATE IMPURITY D [EP IMPURITY]

Common Name

English

6,7-DIMETHOXYQUINAZOLINE-2,4-DIOL

Systematic Name

English

2,5-DIHYDROXY-6,7-DIMETHOXYQUINAZOLINE

Systematic Name

English

6,7-DIMETHOXY-2,4(1H,3H)-QUINAZOLINEDIONE

Systematic Name

English

DOXAZOSIN RELATED COMPOUND B [USP-RS]

Common Name

English

DOXAZOSIN RELATED COMPOUND B

Common Name

English

Code System Code Type Description

ECHA (EC/EINECS)

249-288-1