6,7-DIMETHOXYQUINAZOLINE-2,4(1H,3H)-DIONE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C10H10N2O4
Molecular Weight	222.1974
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of 6,7-DIMETHOXYQUINAZOLINE-2,4(1H,3H)-DIONE

SMILES

COC1=CC2=C(C=C1OC)C(=O)NC(=O)N2

InChI

InChIKey=KWNQIIMVPSMYEM-UHFFFAOYSA-N

InChI=1S/C10H10N2O4/c1-15-7-3-5-6(4-8(7)16-2)11-10(14)12-9(5)13/h3-4H,1-2H3,(H2,11,12,13,14)

HIDE SMILES / InChI

Molecular Formula	C10H10N2O4
Molecular Weight	222.1974
Charge	0
Count	MOL RATIO 1 MOL RATIO (average)

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description

6,7-dimethoxyquinazoline-2,4(1H,3H)-dione is useful as a building block in the synthesis of alpha adrenergic receptor antagonists such as Prazosin, Bunazosin and Doxazosin, and which are useful as antihypertensive agents.

Approval Year

Conditions

Conditions

Condition	Modality	Targets	Highest Phase	Product
Unknown 2,578

PubMed

PubMed

Title	Date	PubMed
A new and facile synthesis of quinazoline-2,4(1H,3H)-diones.	2009 Mar 19	19239261

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

Unknown

Substance Class	Chemical
Record UNII	K7867Z125J
Record Status	`Validated (UNII)`
Record Version

Show entries

Name

Type

Language

6,7-DIMETHOXYQUINAZOLINE-2,4(1H,3H)-DIONE

Systematic Name

English

USP DOXAZOSIN RELATED COMPOUND B [USP IMPURITY]

Common Name

English

6,7-DIMETHOXY-1H-QUINAZOLINE-2,4-DIONE

Systematic Name

English

DOXAZOSIN IMPURITY D

Common Name

English

6,7-DIMETHOXYQUINAZOLINE-2,4-DIONE

Systematic Name

English

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Code System

Code

Type

Description

ECHA (EC/EINECS)

249-288-1

PRIMARY

FDA UNII

K7867Z125J

PRIMARY

PUBCHEM

120081

PRIMARY

CAS

28888-44-0

PRIMARY

EPA CompTox

DTXSID9046100

PRIMARY

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