LOTRIFEN

Details

Stereochemistry	ACHIRAL
Molecular Formula	C16H10ClN3
Molecular Weight	279.724
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

ClC1=CC=C(C=C1)C2=NN3C=CC4=C(C=CC=C4)C3=N2

InChI

InChIKey=DGWUVKLBXCWNTA-UHFFFAOYSA-N

InChI=1S/C16H10ClN3/c17-13-7-5-12(6-8-13)15-18-16-14-4-2-1-3-11(14)9-10-20(16)19-15/h1-10H

HIDE SMILES / InChI

Description
Sources: http://www.daproga.com/web/seccion/pagina/contenido/plantillas/producto.php?id=1800 | https://www.drugs.com/international/lotrifen.html

Lotrifen is a non-hormonal abortifacient agent. It is used in veterinary. Lotrifen causes the arrest and involution of pregnancy. It acts, after the implantation of the blastocyst, directly on the product of conception, which undergoes a slow and gradual degenerative process and ends with the reabsorption or expulsion of it.

Originator

Approval Year

PubMed

Title	Date	PubMed
Adverse effects of the antifertility agent DL 717-IT (Canocenta, Byk Gulden, FRG). Pathological findings in the rabbit.	1989-01	2916081
Development of novel embryotoxic compounds for interceptive fertility control in the dog.	1989	2621727

Patents

Sample Use Guides

In Vivo Use Guide

Veterinary use. Single dose of 0.05 ml/kg (equivalent to 2.5 mg of active ingredient per ml of solution) between days 9 and 13 after coupling

Route of Administration: Intramuscular

Name

Type

Language

LOTRIFEN [MI]

Preferred Name

English

LOTRIFEN

Official Name

English

2-(P-CHLOROPHENYL)-S-TRIAZOLO(5,1-A)ISOQUINOLINE

Common Name

English

lotrifen [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C542