LOTRIFEN

Details

Stereochemistry	ACHIRAL
Molecular Formula	C16H10ClN3
Molecular Weight	279.724
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

ClC1=CC=C(C=C1)C2=NN3C=CC4=CC=CC=C4C3=N2

InChI

InChIKey=DGWUVKLBXCWNTA-UHFFFAOYSA-N

InChI=1S/C16H10ClN3/c17-13-7-5-12(6-8-13)15-18-16-14-4-2-1-3-11(14)9-10-20(16)19-15/h1-10H

HIDE SMILES / InChI

Molecular Formula	C16H10ClN3
Molecular Weight	279.724
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: http://www.daproga.com/web/seccion/pagina/contenido/plantillas/producto.php?id=1800 | https://www.drugs.com/international/lotrifen.html

Lotrifen is a non-hormonal abortifacient agent. It is used in veterinary. Lotrifen causes the arrest and involution of pregnancy. It acts, after the implantation of the blastocyst, directly on the product of conception, which undergoes a slow and gradual degenerative process and ends with the reabsorption or expulsion of it.

Originator

Approval Year

PubMed

Title	Date	PubMed
Development of novel embryotoxic compounds for interceptive fertility control in the dog.	1989	2621727
Adverse effects of the antifertility agent DL 717-IT (Canocenta, Byk Gulden, FRG). Pathological findings in the rabbit.	1989 Jan	2916081

Patents

Sample Use Guides

In Vivo Use Guide

Veterinary use. Single dose of 0.05 ml/kg (equivalent to 2.5 mg of active ingredient per ml of solution) between days 9 and 13 after coupling

Route of Administration: Intramuscular

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:32:34 GMT 2023` Edited by `admin` on `Fri Dec 15 15:32:34 GMT 2023`
Record UNII	K6J75G277H
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

LOTRIFEN

Official Name

English

LOTRIFEN [MI]

Common Name

English

2-(P-CHLOROPHENYL)-S-TRIAZOLO(5,1-A)ISOQUINOLINE

Common Name

English

lotrifen [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C542