TETRAISOPROPYL METHYLENEDIPHOSPHONATE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C13H30O6P2
Molecular Weight	344.3212
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of TETRAISOPROPYL METHYLENEDIPHOSPHONATE

Structure Search

SMILES

CC(C)OP(=O)(CP(=O)(OC(C)C)OC(C)C)OC(C)C

InChI

InChIKey=ODTQUKVFOLFLIQ-UHFFFAOYSA-N

InChI=1S/C13H30O6P2/c1-10(2)16-20(14,17-11(3)4)9-21(15,18-12(5)6)19-13(7)8/h10-13H,9H2,1-8H3

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Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/15115414 | https://www.ncbi.nlm.nih.gov/pubmed/10400344 | https://www.ncbi.nlm.nih.gov/pubmed/15615539

Tetraisopropyl methylenediphosphonate used in the synthesis of unsaturated phosphonocholines with enantioselective effects on neuronal tumor cell proliferation and viability. Also is used in the preparation of E2-bisphosphonate conjugates as potential anti-osteoporosis agents and in the preparation of AZT 5’-Triphosphate compounds, which display inhibitory effects on HIV-1 reverse transcriptase.

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Unknown 2596

PubMed

Title	Date	PubMed
Phosphorus stabilized carbene complexes: bisphosphonate dianion synthesis, reactivity and DFT studies of O~C~O zirconium(IV) complexes.	2010-01-14	20023986
Synthesis of AZT 5'-triphosphate mimics and their inhibitory effects on HIV-1 reverse transcriptase.	2004-12-30	15615539
Synthesis and use of novel ether phospholipid enantiomers to probe the molecular basis of the antitumor Effects of alkyllysophospholipids: correlation of differential activation of c-Jun NH(2)-terminal protein kinase with antiproliferative effects in neuronal tumor cells.	2004-05-06	15115414
Prostaglandin E2-bisphosphonate conjugates: potential agents for treatment of osteoporosis.	1999-05	10400344
Some phosphonic acid analogs as inhibitors of pyrophosphate-dependent phosphofructokinase, a novel target in Toxoplasma gondii.	1995-01-06	7840776

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

Unknown

Name

Type

Language

NSC-226577

Preferred Name

English

TETRAISOPROPYL METHYLENEDIPHOSPHONATE

Systematic Name

English

METHYLENEDIPHOSPHONIC ACID TETRAISOPROPYL ESTER

Systematic Name

English

PHOSPHONIC ACID, METHYLENEDI-, TETRAISOPROPYL ESTER

Systematic Name

English

((DIISOPROPOXYPHOSPHINYL)METHYL)DIISOPROPOXYPHOSPHINE OXIDE

Systematic Name

English

TETRAISOPROPYL METHYLENEBISPHOSPHONATE

Systematic Name

English

PHOSPHONIC ACID, P,P'-METHYLENEBIS-, P,P,P',P'-TETRAKIS(1-METHYLETHYL) ESTER

Systematic Name

English

PHOSPHONIC ACID, METHYLENEBIS-, TETRAKIS(1-METHYLETHYL) ESTER

Systematic Name

English

TETRAKIS(O-ISOPROPYL) METHYLENEDIPHOSPHONATE

Systematic Name

English

Code System Code Type Description

ECHA (EC/EINECS)

216-765-0