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Details

Stereochemistry ACHIRAL
Molecular Formula C10H10N4OS
Molecular Weight 234.278
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 1
Charge 0

SHOW SMILES / InChI
Structure of METHISAZONE

SMILES

CN1C(=O)\C(=N\NC(N)=S)C2=CC=CC=C12

InChI

InChIKey=DLGSOJOOYHWROO-XYOKQWHBSA-N
InChI=1S/C10H10N4OS/c1-14-7-5-3-2-4-6(7)8(9(14)15)12-13-10(11)16/h2-5H,1H3,(H3,11,13,16)/b12-8+

HIDE SMILES / InChI

Description

Methisazone is N-methyl-isatin beta-thiosemicarbazone. This is one of a series of isatin beta-thiosemicarbazones which have been shown in the laboratory to have antiviral activity against vaccinia and variola viruses. It has been reported to be effective for smallpox prophylaxis.

Approval Year

Unknown
149,124

PubMed

Patents

JP3553083B2
51

Sample Use Guides

In Vivo Use Guide
The present recommendations are that adults should receive 6 g. methisazone (four capsules of Marboran) a day, taken 3 g. in the morning and 3 g. in the evening. Dosage is halved for children between 3 and 10 and proportionately reduced still further for infants.
Route of Administration: Oral
ACTIVE MOIETY
Structure of METHISAZONE
NIH
NCATS
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