METHISAZONE

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ACHIRAL
Molecular Formula	C10H10N4OS
Molecular Weight	234.278
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure of METHISAZONE

Structure Search

SMILES

CN1C(=O)\C(=N\NC(N)=S)C2=C1C=CC=C2

InChI

InChIKey=DLGSOJOOYHWROO-XYOKQWHBSA-N

InChI=1S/C10H10N4OS/c1-14-7-5-3-2-4-6(7)8(9(14)15)12-13-10(11)16/h2-5H,1H3,(H3,11,13,16)/b12-8+

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/14171075 | https://www.ncbi.nlm.nih.gov/pubmed/15578369/

Methisazone is N-methyl-isatin beta-thiosemicarbazone. This is one of a series of isatin beta-thiosemicarbazones which have been shown in the laboratory to have antiviral activity against vaccinia and variola viruses. It has been reported to be effective for smallpox prophylaxis.

Approval Year

PubMed

PubMed

Title	Date	PubMed
Cidofovir in the treatment of poxvirus infections.	2002 Jul	12076747

Patents

Patents

Sample Use Guides

In Vivo Use Guide

The present recommendations are that adults should receive 6 g. methisazone (four capsules of Marboran) a day, taken 3 g. in the morning and 3 g. in the evening. Dosage is halved for children between 3 and 10 and proportionately reduced still further for infants.

Route of Administration: Oral

Name

Type

Language

METHISAZONE

Official Name

English

BW-33-T-57

Code

English

NSC-69811

Code

English

metisazone [INN]

Common Name

English

METISAZONE

Official Name

English

1-Methylindole-2,3-dione 3-(thiosemicarbazone)

Systematic Name

English

METISAZONE [MART.]

Common Name

English

METHISAZONE [MI]

Common Name

English

BW 33-T-57

Code

English

Metisazone [WHO-DD]

Common Name

English

METHISAZONE [USAN]

Common Name

English

NSC-70969

Code

English

Classification Tree Code System Code

WHO-VATC

QJ05AA01

Created by admin on Fri Dec 15 15:10:32 GMT 2023 , Edited by admin on Fri Dec 15 15:10:32 GMT 2023

WHO-ATC

J05AA01

Created by admin on Fri Dec 15 15:10:32 GMT 2023 , Edited by admin on Fri Dec 15 15:10:32 GMT 2023

NCI_THESAURUS

C281

Created by admin on Fri Dec 15 15:10:32 GMT 2023 , Edited by admin on Fri Dec 15 15:10:32 GMT 2023

Code System Code Type Description

PUBCHEM

5357051

Created by admin on Fri Dec 15 15:10:32 GMT 2023 , Edited by admin on Fri Dec 15 15:10:32 GMT 2023

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WIKIPEDIA

METISAZONE

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DRUG BANK

DB13641

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ECHA (EC/EINECS)

217-616-2

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NSC

70969

Created by admin on Fri Dec 15 15:10:32 GMT 2023 , Edited by admin on Fri Dec 15 15:10:32 GMT 2023

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EPA CompTox

DTXSID7046413

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INN

1742

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CAS

1910-68-5

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ChEMBL

CHEMBL362994

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NCI_THESAURUS

C77928

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FDA UNII

K3QML4J07E

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MERCK INDEX

m7319

Created by admin on Fri Dec 15 15:10:32 GMT 2023 , Edited by admin on Fri Dec 15 15:10:32 GMT 2023

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Merck Index

NSC

69811

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EVMPD

SUB08895MIG

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DRUG CENTRAL

1746

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SMS_ID

100000080935

Created by admin on Fri Dec 15 15:10:32 GMT 2023 , Edited by admin on Fri Dec 15 15:10:32 GMT 2023

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ACTIVE MOIETY


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