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Details

Stereochemistry ACHIRAL
Molecular Formula C10H10N4OS
Molecular Weight 234.278
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 1
Charge 0

SHOW SMILES / InChI
Structure of METHISAZONE

SMILES

CN1C(=O)\C(=N\NC(N)=S)C2=C1C=CC=C2

InChI

InChIKey=DLGSOJOOYHWROO-XYOKQWHBSA-N
InChI=1S/C10H10N4OS/c1-14-7-5-3-2-4-6(7)8(9(14)15)12-13-10(11)16/h2-5H,1H3,(H3,11,13,16)/b12-8+

HIDE SMILES / InChI

Molecular Formula C10H10N4OS
Molecular Weight 234.278
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 1
Optical Activity NONE

Description

Methisazone is N-methyl-isatin beta-thiosemicarbazone. This is one of a series of isatin beta-thiosemicarbazones which have been shown in the laboratory to have antiviral activity against vaccinia and variola viruses. It has been reported to be effective for smallpox prophylaxis.

Approval Year

PubMed

Patents

Sample Use Guides

In Vivo Use Guide
The present recommendations are that adults should receive 6 g. methisazone (four capsules of Marboran) a day, taken 3 g. in the morning and 3 g. in the evening. Dosage is halved for children between 3 and 10 and proportionately reduced still further for infants.
Route of Administration: Oral
Substance Class Chemical
Record UNII
K3QML4J07E
Record Status Validated (UNII)
Record Version