TRISODIUM HEDTA

Details

Stereochemistry	ACHIRAL
Molecular Formula	C10H15N2O7.3Na
Molecular Weight	344.2046
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[Na+].[Na+].[Na+].OCCN(CCN(CC([O-])=O)CC([O-])=O)CC([O-])=O

InChI

InChIKey=WHNXAQZPEBNFBC-UHFFFAOYSA-K

InChI=1S/C10H18N2O7.3Na/c13-4-3-11(5-8(14)15)1-2-12(6-9(16)17)7-10(18)19;;;/h13H,1-7H2,(H,14,15)(H,16,17)(H,18,19);;;/q;3*+1/p-3

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/22251571 | https://www.ncbi.nlm.nih.gov/pubmed/22575537

HYDROXYETHYLETHYLENEDIAMINETRIACETIC ACID (HEDTA) is used in cosmetics and care products. It’s a chelating agent, which in combination with selenium was effective in reducing the concentration of Al and level of DNA damage. In addition, experiments with rodents have shown that combination of HEDTA and propolis preserved histological features, mitigated oxidative stress and improved liver, kidney, and brain functions more profoundly.

Approval Year

PubMed

Title	Date	PubMed
Biodegradability of ethylenediamine-based complexing agents and related compounds.	2001 Aug	11482674
Beneficial effects of humic acid on micronutrient availability to wheat.	2001 Nov-Dec	11885604
Phytosiderophores influence on cadmium mobilization and uptake by wheat and barley plants.	2001 Nov-Dec	11790018
EDTA and HEDTA effects on Cd, Cr, and Ni uptake by Helianthus annuus.	2001 Oct	11572587
High-pressure pulse-radiolysis study of the formation and decomposition of complexes with iron-carbon sigma bonds: mechanistic comparison for different metal centers.	2001 Sep 10	11531445
Final report on the safety assessment of EDTA, calcium disodium EDTA, diammonium EDTA, dipotassium EDTA, disodium EDTA, TEA-EDTA, tetrasodium EDTA, tripotassium EDTA, trisodium EDTA, HEDTA, and trisodium HEDTA.	2002	12396676
Determination of strong binding chelators and their metal complexes by anion-exchange chromatography and inductively coupled plasma mass spectrometry.	2002 Feb 22	11883654
Direct modulation of volume-regulated anion channels by Ca(2+) chelating agents.	2002 Jun 19	12067708
On-column complexation and simultaneous separation of vanadium(IV) and vanadium(V) by capillary electrophoresis with direct UV detection.	2002 Oct	12373403
Effect of N-hydroxyethyl-ethylenediamine-triacetic acid (HEDTA) on Cr(VI) reduction by Fe(II).	2003 Jun	12697190
Preparation of Gd3+-containing polymer complex as a novel magnetic resonance signal-enhancing coating material.	2003 Mar	15348476
Aluminum-induced oxidative stress in rat brain: response to combined administration of citric acid and HEDTA.	2003 Mar	12643979
Isothermal titration calorimetric procedure to determine protein-metal ion binding parameters in the presence of excess metal ion or chelator.	2003 Mar 15	12654309
Inactivation of human glutamate dehydrogenase by aluminum.	2003 Nov	14625697
Biogeochemistry of fluoride in a plant-solution system.	2003 Nov-Dec	14674546
Light-catalyzed chromium(VI) reduction by organic compounds and soil minerals.	2003 Nov-Dec	14674529
Functional and structural study on chelator-induced suppression of S2/S1 FTIR spectrum in photosynthetic oxygen-evolving complex.	2003 Oct 1	14512202
Immobilization of Fe chelators on sepharose gel and its effect on their chemical properties.	2003 Sep 24	13129308
Antioxidant defense in a lead accumulating plant, Sesbania drummondii.	2004 Dec	15694284
The excitation cascade of Limulus ventral photoreceptors: guanylate cyclase as the link between InsP3-mediated Ca2+ release and the opening of cGMP-gated channels.	2004 Feb 26	15053840
Separation of yttrium from heavy lanthanide by CA-100 using the complexing agent.	2004 May 28	18969423
The [Ru(Hedta)NO](0.1-) system: structure, chemical reactivity and biological assays.	2004 Nov	15522418
Equilibrium, kinetic and solvent effect studies on the reactions of [RuIII(Hedta)(H2O)] with thiols.	2005 Dec 21	16311647
Potential of Hemidesmus indicus for phytoextraction of lead from industrially contaminated soils.	2005 Jan	15620742
Speciation of chromium(III) and cobalt(III) (amino)carboxylate complexes using capillary electrophoresis.	2005 Jan 1	15623291
Macrocyclic lanthanide complexes as artificial nucleases and ribonucleases: effects of pH, metal ionic radii, number of coordinated water molecules, charge, and concentrations of the metal complexes.	2005 Sep 19	16156622
Neutrophil secretion induced by an intracellular Ca2+ rise and followed by whole-cell patch-clamp recordings occurs without any selective mobilization of different granule populations.	2006	16883058
Improving sensitivity in simultaneous determination of copper carboxylates by nonaqueous capillary electrophoresis.	2006 Mar 31	16464460
Effects of lead and chelators on growth, photosynthetic activity and Pb uptake in Sesbania drummondii grown in soil.	2006 Nov	16522347
Separation of chelating agents as copper complexes by capillary zone electrophoresis using quaternary ammonium bromides as additives in N-methylformamide.	2006 Oct 27	17723760
Iron acquisition by phytosiderophores contributes to cadmium tolerance.	2007 Apr	17337530
Determination of alternative and conventional chelating agents as copper(II) complexes by capillary zone electrophoresis--the first use of didecyldimethylammonium bromide as a flow reversal reagent.	2007 Feb 12	17386596
Confirmation of vanadium complex formation using electrospray mass spectrometry and determination of vanadium speciation by sample stacking capillary electrophoresis.	2007 Feb 28	17386644
Determination of synthetic ferric chelates used as fertilizers by liquid chromatography-electrospray/mass spectrometry in agricultural matrices.	2007 Jan	17010641
A dendrite-autonomous mechanism for direction selectivity in retinal starburst amacrine cells.	2007 Jul	17622194
Solubility and accumulation of metals in Chinese brake fern, vetiver and rostrate sesbania using chelating agents.	2007 Jul-Aug	18246709
Influence of soil type on the mobility and bioavailability of chelated zinc.	2007 May 2	17407310
Determination of sequestering agents in cosmetics and synthetic detergents by high-performance liquid chromatography with ultraviolet detection.	2007 Nov 9	17920069
Homeostatic control of slow vacuolar channels by luminal cations and evaluation of the channel-mediated tonoplast Ca2+ fluxes in situ.	2008	18832189
Kosmotropes enhance the yield of antibody purified by affinity chromatography using immobilized bacterial immunoglobulin binding proteins.	2008	18080884
Polyamine-polycarboxylate metal complexes with different biological effectiveness as nitric oxide scavengers. Clues for drug design.	2008 Jun 12	18484716
Poly[μ-aqua-diaqua-(μ(3)-N'-carboxy-methyl-ethylenediamine-N,N,N'-tri-acetato)oxidopotassium(I)vanadium(IV)].	2008 Jun 7	21202763
Limits of calcium clearance by plasma membrane calcium ATPase in olfactory cilia.	2009	19390572
The dystrophin complex controls bk channel localization and muscle activity in Caenorhabditis elegans.	2009 Dec	20019812
Speciation of Zn-aminopolycarboxylic complexes by electrospray ionization mass spectrometry and ion chromatography with inductively coupled plasma mass spectrometry.	2009 Feb	19127531
A novel manganese complex effective as superoxide anion scavenger and therapeutic agent against cell and tissue oxidative injury.	2009 Nov 26	19860434
Development of a novel aluminum tolerance phenotyping platform used for comparisons of cereal aluminum tolerance and investigations into rice aluminum tolerance mechanisms.	2010 Aug	20538888
Spatial distribution of calcium-gated chloride channels in olfactory cilia.	2010 Dec 30	21209888
Interdomain interactions control Ca2+-dependent potentiation in the cation channel TRPV4.	2010 May 11	20485495
Poly[[[μ(3)-N'-(carboxymethyl)ethylene-di-amine-N,N,N'-triacetato]dysprosium(III)] trihydrate].	2010 Oct 23	21588859

Name

Type

Language

TRISODIUM HEDTA

Official Name

English

N-(HYDROXYETHYL)-N,N',N'-ETHYLENEDIAMINETRIACETIC ACID TRISODIUM SALT

Common Name

English

GLYCINE, N-(2-(BIS(CARBOXYMETHYL)AMINO)ETHYL)-N-(2-HYDROXYETHYL)-, TRISODIUM SALT

Common Name

English

TRISODIUM N-HYDROXYETHYLETHYLENEDIAMINETRIACETATE

Common Name

English

N-(2-(BIS(CARBOXYMETHYL)AMINO)ETHYL)-N-(2-HYDROXYETHYL)GLYCINE TRISODIUM SALT

Common Name

English

TRISODIUM HEDTA [II]

Common Name

English

TRISODIUM HEDTA [INCI]

Common Name

English

SODIUM HEDTA

Common Name

English

TRISODIUM HYDROXYETHYLETHYLENEDIAMINETRIACETATE

Common Name

English

VERSENOL [MI]

Common Name

English

TRISODIUM N-HYDROXYETHYLETHYLENEDIAMINETRIACETATE [HSDB]

Common Name

English

NSC-148338

Code

English

TRISODIUM 2-(CARBOXYLATOMETHYL(2-HYDROXYETHYL)AMINO)ETHYLIMINODI(ACETATE)

Systematic Name

English

Classification Tree Code System Code

EPA PESTICIDE CODE

39109