Corticotropin is a polypeptide hormone produced and secreted by the pituitary gland. Corticotropin acts through the stimulation of cell surface the adrenocorticotropic hormone (ACTH) receptors, which are primarily located on the adrenocortical cells. Corticotropin stimulates the cortex of the adrenal gland and boosts the synthesis of corticosteroids, mainly glucocorticoids but also sex steroids (androgens).
Corticotropin is indicated as monotherapy for the treatment of exacerbations of multiple sclerosis in adults and infantile spasms in infants and children under 2 years of age. Controlled clinical trials have shown Corticotropin to be effective in speeding the resolution of acute exacerbations of multiple sclerosis. However, there is no evidence that it affects the ultimate outcome or natural history of the disease. The mechanism of action of Corticotropin in the treatment of infantile spasms is unknown.
Approval Year
Conditions
Condition | Modality | Targets | Highest Phase | Product |
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Primary | ACTHAR Approved UseH.P. Acthar Gel is an adrenocorticotropic hormone (ACTH) analogue indicated as monotherapy for the treatment of infantile spasms in infants and children under 2 years of age; H.P. Acthar Gel is indicated for the treatment of exacerbations of multiple
sclerosis in adults; H.P. Acthar Gel may be used for the following disorders and diseases: rheumatic; collagen; dermatologic; allergic states; ophthalmic; respiratory; and edematous state. Launch Date-6.1534077E11 |
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Primary | ACTHAR Approved UseH.P. Acthar Gel is an adrenocorticotropic hormone (ACTH) analogue indicated as monotherapy for the treatment of infantile spasms in infants and children under 2 years of age; H.P. Acthar Gel is indicated for the treatment of exacerbations of multiple
sclerosis in adults; H.P. Acthar Gel may be used for the following disorders and diseases: rheumatic; collagen; dermatologic; allergic states; ophthalmic; respiratory; and edematous state. Launch Date-6.1534077E11 |
PubMed
Title | Date | PubMed |
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[Neuropsychiatric complications caused by cortisone and ACTH. (Clinico-social considerations)]. | 1968 Apr-Jun |
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Reversible cerebral atrophy and corticotrophin. | 1979 Jul 28 |
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Transient brain shrinkage in infantile spasms after ACTH treatment. Report of two cases. | 1980 Feb |
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Cerebral atrophy following ACTH therapy. | 1980 Feb |
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Aicardi's syndrome: are corticosteroids teratogens? | 1981 Jan |
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[Collateral transient behavioural changes during ACTH therapy in infantile generalized epilepsy (author's transl)]. | 1981 Mar-Jun |
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Sequential CT studies of 24 children with infantile spasms on ACTH therapy. | 1983 Aug |
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'Dystonia'-like postural asymmetry after microinjection of ACTH N-terminal fragments but not after ACTH1-39 in rat brainstem suggests role of neuropeptide mutation in genetic movement disorder. | 1984 Feb 27 |
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Acute-onset transient hydrocephalus after suspension of ACTH therapy for infantile spasms: a case report. | 1984 Jun |
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Administration of ACTH to suckling rats results in hyperkinetic behavior. | 1986 |
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[Long-term prognosis of infantile spasms after standard ACTH treatment in Japan]. | 1986 Sep |
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ACTH and vasopressin responses to insulin-induced hypoglycemia in intact and neurohypophysectomized conscious dogs. | 1991 Jan |
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Activity of adenosine deaminase in red blood cells of patients suffering from multiple sclerosis treated with adrenocorticotropic hormone. | 1995 Nov-Dec |
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Effects of chronic 'Binge' cocaine administration on plasma ACTH and corticosterone levels in mice deficient in DARPP-32. | 1999 Sep |
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Association of exaggerated HPA axis response to the initial injection of interferon-alpha with development of depression during interferon-alpha therapy. | 2003 Jul |
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Integrated hemodynamic, hormonal, and renal actions of urocortin 2 in normal and paced sheep: beneficial effects in heart failure. | 2005 Dec 6 |
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Therapeutic efficacy and adverse effects of adrenocorticotropic hormone therapy in west syndrome: differences in dosage of adrenocorticotropic hormone, onset of age, and cause. | 2006 Apr |
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Aryl hydrocarbon receptor activation impairs cortisol response to stress in rainbow trout by disrupting the rate-limiting steps in steroidogenesis. | 2006 Apr |
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Repeated electroconvulsive stimuli increase brain-derived neurotrophic factor in ACTH-treated rats. | 2006 Jan 4 |
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Sex specific associations between common glucocorticoid receptor gene variants and hypothalamus-pituitary-adrenal axis responses to psychosocial stress. | 2007 Oct 15 |
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Effects of imipramine and bupropion on the duration of immobility of ACTH-treated rats in the forced swim test: involvement of the expression of 5-HT2A receptor mRNA. | 2008 Feb |
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Partial 17alpha-hydroxylase/17,20-lyase deficiency-clinical report of five Chinese 46,XX cases. | 2008 Jul |
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Long-term weekly ACTH therapy for relapsed West syndrome. | 2008 Jun |
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Chronic coadministration of carbamazepine together with imipramine produces antidepressant-like effects in an ACTH-induced animal model of treatment-resistant depression: involvement of 5-HT(2A) receptors? | 2008 May |
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Malignant pituitary corticotroph adenomas: report of two cases and a comprehensive review of the literature. | 2009 |
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The role of ether-a-go-go-related gene K(+) channels in glucocorticoid inhibition of adrenocorticotropin release by rat pituitary cells. | 2009 Jan 8 |
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Classification Tree | Code System | Code | ||
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FDA ORPHAN DRUG |
399113
Created by
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CFR |
21 CFR 862.1025
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NDF-RT |
N0000006478
Created by
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LOINC |
14674-6
Created by
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WHO-VATC |
QH01AA01
Created by
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LOINC |
15042-5
Created by
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LOINC |
2141-0
Created by
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NDF-RT |
N0000006478
Created by
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FDA ORPHAN DRUG |
168103
Created by
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NDF-RT |
N0000006478
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LOINC |
6879-1
Created by
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NDF-RT |
N0000006478
Created by
admin on Sat Jun 26 17:00:17 UTC 2021 , Edited by admin on Sat Jun 26 17:00:17 UTC 2021
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NDF-RT |
N0000006478
Created by
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LOINC |
2140-2
Created by
admin on Sat Jun 26 17:00:17 UTC 2021 , Edited by admin on Sat Jun 26 17:00:17 UTC 2021
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LOINC |
16652-0
Created by
admin on Sat Jun 26 17:00:17 UTC 2021 , Edited by admin on Sat Jun 26 17:00:17 UTC 2021
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NDF-RT |
N0000006478
Created by
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LOINC |
66732-9
Created by
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NDF-RT |
N0000175941
Created by
admin on Sat Jun 26 17:00:17 UTC 2021 , Edited by admin on Sat Jun 26 17:00:17 UTC 2021
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WHO-ATC |
H01AA01
Created by
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NDF-RT |
N0000006478
Created by
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SUB01465MIG
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12427-33-7
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DB01285
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K0U68Q2TXA
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376
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PRIMARY | RxNorm | ||
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CHEMBL1201610
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Corticotropin
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1366
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4931
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1149004
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PRIMARY | USP-RS | ||
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3633
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M1395
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PRIMARY | Merck Index | ||
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C212
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16132265
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D000324
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PRIMARY |
ACTIVE MOIETY