U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Description

Corticotropin is a polypeptide hormone produced and secreted by the pituitary gland. Corticotropin acts through the stimulation of cell surface the adrenocorticotropic hormone (ACTH) receptors, which are primarily located on the adrenocortical cells. Corticotropin stimulates the cortex of the adrenal gland and boosts the synthesis of corticosteroids, mainly glucocorticoids but also sex steroids (androgens). Corticotropin is indicated as monotherapy for the treatment of exacerbations of multiple sclerosis in adults and infantile spasms in infants and children under 2 years of age. Controlled clinical trials have shown Corticotropin to be effective in speeding the resolution of acute exacerbations of multiple sclerosis. However, there is no evidence that it affects the ultimate outcome or natural history of the disease. The mechanism of action of Corticotropin in the treatment of infantile spasms is unknown.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
ACTHAR
Primary
ACTHAR
PubMed

PubMed

TitleDatePubMed
[SYNDROME OF INTRACRANIAL HYPERTENSION CAUSED BY TREATMENT WITH CORTICOTROPIN].
1964 Jan 31
Complications of corticotropin therapy in multiple sclerosis.
1966 Jul 18
Some observations on the hazards of corticosteroid therapy in patients with inflammatory bowel disease.
1967 Mar-Apr
[Neuropsychiatric complications caused by cortisone and ACTH. (Clinico-social considerations)].
1968 Apr-Jun
Steroid myopathy complicating McArdle's disease.
1970 Feb
Reversible cerebral atrophy and corticotrophin.
1979 Jul 28
Transient brain shrinkage in infantile spasms after ACTH treatment. Report of two cases.
1980 Feb
Cerebral atrophy following ACTH therapy.
1980 Feb
Aicardi's syndrome: are corticosteroids teratogens?
1981 Jan
Sequential CT studies of 24 children with infantile spasms on ACTH therapy.
1983 Aug
'Dystonia'-like postural asymmetry after microinjection of ACTH N-terminal fragments but not after ACTH1-39 in rat brainstem suggests role of neuropeptide mutation in genetic movement disorder.
1984 Feb 27
Acute-onset transient hydrocephalus after suspension of ACTH therapy for infantile spasms: a case report.
1984 Jun
Suppressive action of ACTH on growth hormone secretion in patients with infantile spasms.
1985
Cerebral blood flow and brain shrinkage seen on CT during ACTH therapy.
1986
Administration of ACTH to suckling rats results in hyperkinetic behavior.
1986
[Long-term prognosis of infantile spasms after standard ACTH treatment in Japan].
1986 Sep
A dystonia-like syndrome after neuropeptide (MSH/ACTH) stimulation of the rat locus ceruleus.
1988
ACTH and vasopressin responses to insulin-induced hypoglycemia in intact and neurohypophysectomized conscious dogs.
1991 Jan
Infantile spasms in COFS syndrome.
1991 Jul-Aug
Magnetic resonance imaging in infantile spasms: effects of hormonal therapy.
1992 Mar-Apr
Activity of adenosine deaminase in red blood cells of patients suffering from multiple sclerosis treated with adrenocorticotropic hormone.
1995 Nov-Dec
Nelson's syndrome due to an intracavernous corticotropin-secreting adenoma.
1999 May-Jun
Effects of chronic 'Binge' cocaine administration on plasma ACTH and corticosterone levels in mice deficient in DARPP-32.
1999 Sep
Paraventricular nucleus administration of calcitonin gene-related peptide inhibits food intake and stimulates the hypothalamo-pituitary-adrenal axis.
2003 Apr
Association of exaggerated HPA axis response to the initial injection of interferon-alpha with development of depression during interferon-alpha therapy.
2003 Jul
Inhibition of CYP17 expression by adrenal androgens and transforming growth factor beta in adrenocortical cells.
2004
Integrated hemodynamic, hormonal, and renal actions of urocortin 2 in normal and paced sheep: beneficial effects in heart failure.
2005 Dec 6
Therapeutic efficacy and adverse effects of adrenocorticotropic hormone therapy in west syndrome: differences in dosage of adrenocorticotropic hormone, onset of age, and cause.
2006 Apr
Aryl hydrocarbon receptor activation impairs cortisol response to stress in rainbow trout by disrupting the rate-limiting steps in steroidogenesis.
2006 Apr
Repeated electroconvulsive stimuli increase brain-derived neurotrophic factor in ACTH-treated rats.
2006 Jan 4
Sex specific associations between common glucocorticoid receptor gene variants and hypothalamus-pituitary-adrenal axis responses to psychosocial stress.
2007 Oct 15
Effects of imipramine and bupropion on the duration of immobility of ACTH-treated rats in the forced swim test: involvement of the expression of 5-HT2A receptor mRNA.
2008 Feb
Partial 17alpha-hydroxylase/17,20-lyase deficiency-clinical report of five Chinese 46,XX cases.
2008 Jul
Long-term weekly ACTH therapy for relapsed West syndrome.
2008 Jun
Chronic coadministration of carbamazepine together with imipramine produces antidepressant-like effects in an ACTH-induced animal model of treatment-resistant depression: involvement of 5-HT(2A) receptors?
2008 May
Malignant pituitary corticotroph adenomas: report of two cases and a comprehensive review of the literature.
2009
The role of ether-a-go-go-related gene K(+) channels in glucocorticoid inhibition of adrenocorticotropin release by rat pituitary cells.
2009 Jan 8

Sample Use Guides

In Vivo Use Guide
The usual dose of Corticotropin is 40-80 units given intramuscularly or subcutaneously every 24-72 hours.
Route of Administration: intramuscularly
Name Type Language
CORTICOTROPIN
GREEN BOOK   INN   ORANGE BOOK   USP   VANDF   WHO-DD  
INN  
Official Name English
CORTROPHIN
Brand Name English
CORTICOTROPIN [ORANGE BOOK]
Common Name English
ADRENOCORTICOTROPHIN
HPUS  
Common Name English
25-ASP-30-GLN-CORTICOTROPIN PORCINE
Common Name English
ACTH [MI]
Common Name English
CORTICOTROPIN [VANDF]
Common Name English
CORTICOTROPIN (ACTH)
Common Name English
ACTHAR
Brand Name English
ACTH
MI  
Brand Name English
CORTICOTROPIN [USP]
Common Name English
CORTICOTROPHIN
Common Name English
ADRENOCORTICOTROPIC HORMONE
Common Name English
CORTICOTROPIN [INN]
Common Name English
CORTICOTROPIN [GREEN BOOK]
Common Name English
ADRENOCORTICOTROPHIN [HPUS]
Common Name English
CORTICOTROPIN [WHO-DD]
Common Name English
PURIFIED CORTROPHIN GEL
Brand Name English
.ALPHA.1-39-CORTICOTROPIN (SWINE), 25-L-ASPARTIC ACID-30-L-GLUTAMINE
Common Name English
Classification Tree Code System Code
FDA ORPHAN DRUG 399113
Created by admin on Tue Oct 22 00:49:07 UTC 2019 , Edited by admin on Tue Oct 22 00:49:07 UTC 2019
CFR 21 CFR 862.1025
Created by admin on Tue Oct 22 00:49:07 UTC 2019 , Edited by admin on Tue Oct 22 00:49:07 UTC 2019
NDF-RT N0000006478
Created by admin on Tue Oct 22 00:49:07 UTC 2019 , Edited by admin on Tue Oct 22 00:49:07 UTC 2019
WHO-VATC QH01AA01
Created by admin on Tue Oct 22 00:49:07 UTC 2019 , Edited by admin on Tue Oct 22 00:49:07 UTC 2019
NDF-RT N0000006478
Created by admin on Tue Oct 22 00:49:07 UTC 2019 , Edited by admin on Tue Oct 22 00:49:07 UTC 2019
FDA ORPHAN DRUG 168103
Created by admin on Tue Oct 22 00:49:07 UTC 2019 , Edited by admin on Tue Oct 22 00:49:07 UTC 2019
NDF-RT N0000006478
Created by admin on Tue Oct 22 00:49:07 UTC 2019 , Edited by admin on Tue Oct 22 00:49:07 UTC 2019
NDF-RT N0000006478
Created by admin on Tue Oct 22 00:49:07 UTC 2019 , Edited by admin on Tue Oct 22 00:49:07 UTC 2019
NDF-RT N0000006478
Created by admin on Tue Oct 22 00:49:07 UTC 2019 , Edited by admin on Tue Oct 22 00:49:07 UTC 2019
NDF-RT N0000006478
Created by admin on Tue Oct 22 00:49:07 UTC 2019 , Edited by admin on Tue Oct 22 00:49:07 UTC 2019
NDF-RT N0000175941
Created by admin on Tue Oct 22 00:49:07 UTC 2019 , Edited by admin on Tue Oct 22 00:49:07 UTC 2019
WHO-ATC H01AA01
Created by admin on Tue Oct 22 00:49:07 UTC 2019 , Edited by admin on Tue Oct 22 00:49:07 UTC 2019
NDF-RT N0000006478
Created by admin on Tue Oct 22 00:49:07 UTC 2019 , Edited by admin on Tue Oct 22 00:49:07 UTC 2019
Code System Code Type Description
EVMPD
SUB01465MIG
Created by admin on Tue Oct 22 00:49:07 UTC 2019 , Edited by admin on Tue Oct 22 00:49:07 UTC 2019
PRIMARY
CAS
12427-33-7
Created by admin on Tue Oct 22 00:49:07 UTC 2019 , Edited by admin on Tue Oct 22 00:49:07 UTC 2019
PRIMARY
RXCUI
376
Created by admin on Tue Oct 22 00:49:07 UTC 2019 , Edited by admin on Tue Oct 22 00:49:07 UTC 2019
PRIMARY RxNorm
ChEMBL
CHEMBL1201610
Created by admin on Tue Oct 22 00:49:07 UTC 2019 , Edited by admin on Tue Oct 22 00:49:07 UTC 2019
PRIMARY
INN
1366
Created by admin on Tue Oct 22 00:49:07 UTC 2019 , Edited by admin on Tue Oct 22 00:49:07 UTC 2019
PRIMARY
IUPHAR
3633
Created by admin on Tue Oct 22 00:49:07 UTC 2019 , Edited by admin on Tue Oct 22 00:49:07 UTC 2019
PRIMARY
MERCK INDEX
M1395
Created by admin on Tue Oct 22 00:49:07 UTC 2019 , Edited by admin on Tue Oct 22 00:49:07 UTC 2019
PRIMARY Merck Index
NCI_THESAURUS
C212
Created by admin on Tue Oct 22 00:49:07 UTC 2019 , Edited by admin on Tue Oct 22 00:49:07 UTC 2019
PRIMARY
PUBCHEM
16132265
Created by admin on Tue Oct 22 00:49:07 UTC 2019 , Edited by admin on Tue Oct 22 00:49:07 UTC 2019
PRIMARY
MESH
D000324
Created by admin on Tue Oct 22 00:49:07 UTC 2019 , Edited by admin on Tue Oct 22 00:49:07 UTC 2019
PRIMARY