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Details

Stereochemistry ABSOLUTE
Molecular Formula C19H22F2N2O3S
Molecular Weight 396.451
Optical Activity UNSPECIFIED
Defined Stereocenters 1 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of LY-450108

SMILES

CC(C)S(=O)(=O)NC[C@H](C)C1=CC=C(NC(=O)C2=CC(F)=CC(F)=C2)C=C1

InChI

InChIKey=ACOXQYLJOQAHST-ZDUSSCGKSA-N
InChI=1S/C19H22F2N2O3S/c1-12(2)27(25,26)22-11-13(3)14-4-6-18(7-5-14)23-19(24)15-8-16(20)10-17(21)9-15/h4-10,12-13,22H,11H2,1-3H3,(H,23,24)/t13-/m0/s1

HIDE SMILES / InChI

Description

LY-450108 had been in phase I clinical trial by Lilly, where was shown, that this drug safe and well tolerated in healthy subjects. This drug in the preclinical studies on animal models for the treatment of depression and Parkinson's disease.

CNS Activity

Originator

Eli Lilly
239
Curator's Comment: # Eli Lilly & Co. Ltd

Approval Year

Unknown
149124
Targets

Targets

Primary TargetPharmacologyConditionPotency
Positive Allosteric Modulator
186
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Preclinical
Unknown

Approved Use

Unknown
Primary
Preclinical
Unknown

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
AMPA receptor potentiators: application for depression and Parkinson's disease.
2007-05
Multiple-dose plasma pharmacokinetic and safety study of LY450108 and LY451395 (AMPA receptor potentiators) and their concentration in cerebrospinal fluid in healthy human subjects.
2006-04

Sample Use Guides

In Vivo Use Guide
open-label, multiple oral dose study evaluating 1 mg and 5 mg LY450108
Route of Administration: Oral
In Vitro Use Guide
Unknown
Name Type Language
LY-450108
Code English
3,5-DIFLUORO-N-(4-((1R)-1-METHYL-2-(((1-METHYLETHYL)SULFONYL)AMINO)ETHYL)PHENYL)-BENZAMIDE
Preferred Name English
BENZAMIDE, 3,5-DIFLUORO-N-(4-((1R)-1-METHYL-2-(((1-METHYLETHYL)SULFONYL)AMINO)ETHYL)PHENYL)-
Systematic Name English
3,5-DIFLUORO-N-(4-((1R)-1-METHYL-2-(((1-METHYLETHYL)SULFONYL)AMINO)ETHYL)PHENYL)BENZAMIDE
Systematic Name English
Code System Code Type Description
CAS
376594-67-1
Created by admin on Mon Mar 31 18:06:11 GMT 2025 , Edited by admin on Mon Mar 31 18:06:11 GMT 2025
PRIMARY
EPA CompTox
DTXSID10431720
Created by admin on Mon Mar 31 18:06:11 GMT 2025 , Edited by admin on Mon Mar 31 18:06:11 GMT 2025
PRIMARY
PUBCHEM
9843690
Created by admin on Mon Mar 31 18:06:11 GMT 2025 , Edited by admin on Mon Mar 31 18:06:11 GMT 2025
PRIMARY
FDA UNII
JT47TQ8QOS
Created by admin on Mon Mar 31 18:06:11 GMT 2025 , Edited by admin on Mon Mar 31 18:06:11 GMT 2025
PRIMARY
SUBSTANCE RECORD
Structure of LY-450108
NIH
NCATS
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