LY-450108

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C19H22F2N2O3S
Molecular Weight	396.451
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(C)S(=O)(=O)NC[C@H](C)C1=CC=C(NC(=O)C2=CC(F)=CC(F)=C2)C=C1

InChI

InChIKey=ACOXQYLJOQAHST-ZDUSSCGKSA-N

InChI=1S/C19H22F2N2O3S/c1-12(2)27(25,26)22-11-13(3)14-4-6-18(7-5-14)23-19(24)15-8-16(20)10-17(21)9-15/h4-10,12-13,22H,11H2,1-3H3,(H,23,24)/t13-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C19H22F2N2O3S
Molecular Weight	396.451
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	1 / 1
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/17504104

LY-450108 had been in phase I clinical trial by Lilly, where was shown, that this drug safe and well tolerated in healthy subjects. This drug in the preclinical studies on animal models for the treatment of depression and Parkinson's disease.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Glutamate receptor ionotropic AMPA 41 Target ID: CHEMBL2096670 Sources: https://www.ncbi.nlm.nih.gov/pubmed/16554450	Positive Allosteric Modulator 179

Conditions

Condition	Modality	Targets	Highest Phase	Product
Depression 235 Sources: https://www.ncbi.nlm.nih.gov/pubmed/17504104	Primary		Preclinical	Unknown Approved Use Unknown
Parkinson's disease 226 Sources: https://www.ncbi.nlm.nih.gov/pubmed/17504104	Primary		Preclinical	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
Multiple-dose plasma pharmacokinetic and safety study of LY450108 and LY451395 (AMPA receptor potentiators) and their concentration in cerebrospinal fluid in healthy human subjects.	2006 Apr	16554450

Sample Use Guides

In Vivo Use Guide

open-label, multiple oral dose study evaluating 1 mg and 5 mg LY450108

Route of Administration: Oral

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:42:24 GMT 2023` Edited by `admin` on `Fri Dec 15 15:42:24 GMT 2023`
Record UNII	JT47TQ8QOS
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

LY-450108

Code

English

BENZAMIDE, 3,5-DIFLUORO-N-(4-((1R)-1-METHYL-2-(((1-METHYLETHYL)SULFONYL)AMINO)ETHYL)PHENYL)-

Systematic Name

English

3,5-DIFLUORO-N-(4-((1R)-1-METHYL-2-(((1-METHYLETHYL)SULFONYL)AMINO)ETHYL)PHENYL)BENZAMIDE

Systematic Name

English

3,5-DIFLUORO-N-(4-((1R)-1-METHYL-2-(((1-METHYLETHYL)SULFONYL)AMINO)ETHYL)PHENYL)-BENZAMIDE

Systematic Name

English

Code System Code Type Description

CAS

376594-67-1

Created by admin on Fri Dec 15 15:42:24 GMT 2023 , Edited by admin on Fri Dec 15 15:42:24 GMT 2023

PRIMARY

EPA CompTox

DTXSID10431720

Created by admin on Fri Dec 15 15:42:24 GMT 2023 , Edited by admin on Fri Dec 15 15:42:24 GMT 2023

PRIMARY

PUBCHEM

9843690

Created by admin on Fri Dec 15 15:42:24 GMT 2023 , Edited by admin on Fri Dec 15 15:42:24 GMT 2023

PRIMARY

FDA UNII

JT47TQ8QOS

Created by admin on Fri Dec 15 15:42:24 GMT 2023 , Edited by admin on Fri Dec 15 15:42:24 GMT 2023

PRIMARY

Details

SMILES

InChI

DescriptionSources: https://www.ncbi.nlm.nih.gov/pubmed/17504104

CNS Activity

Originator

Approval Year

Targets

Conditions

Approved Use

Approved Use

PubMed

Sample Use Guides

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/17504104