METHYRIDINE SULFATE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C8H11NO.H2O4S
Molecular Weight	235.258
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OS(O)(=O)=O.COCCC1=NC=CC=C1

InChI

InChIKey=PPJICNUNBYNPQZ-UHFFFAOYSA-N

InChI=1S/C8H11NO.H2O4S/c1-10-7-5-8-4-2-3-6-9-8;1-5(2,3)4/h2-4,6H,5,7H2,1H3;(H2,1,2,3,4)

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Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/17649364 |https://www.ncbi.nlm.nih.gov/pubmed/17649312 | DOI:10.1038/189059a0

Metyridine has been shown to possess anthelmintic activity, particularly for the nematodes of the alimentary canal. Methyridine is able to pass freely through most of the barriers, which maintain body integrity. It produces neuromuscular block of the decamethonium type. There appears to be sufficient difference between the sensitivity of nematode and vertebrate nervous systems to this drug to allow a wide safety margin for its use in animals. Signs of toxicity, principally dullness and lassitude, may be produced by overdosage of the drug. When given subcutaneously methyridine may cause local pain, and swelling.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
neuromuscular synaptic transmission 2 Target ID: GO:0007274 Sources: https://www.ncbi.nlm.nih.gov/pubmed/17649364	Blocker 537
Cholinesterase 14 Target ID: P32753 Gene ID: NA Gene Symbol: BCHE Target Organism: Ovis aries (Sheep) Sources: https://www.ncbi.nlm.nih.gov/pubmed/4391742	Inhibitor 8297

Conditions

Condition	Modality	Targets	Highest Phase	Product
Nematode Infections 2 Sources: https://www.ncbi.nlm.nih.gov/pubmed/17649364	Curative		Approved 8429	Promintic Approved Use Unknown

PubMed

Title	Date	PubMed
Anthelmintic actions on homomer-forming nicotinic acetylcholine receptor subunits: chicken alpha7 and ACR-16 from the nematode Caenorhabditis elegans.	2000	11113327
Methyridine (2-[2-methoxyethyl]-pyridine]) and levamisole activate different ACh receptor subtypes in nematode parasites: a new lead for levamisole-resistance.	2003 Nov	14581174
Oxantel is an N-type (methyridine and nicotine) agonist not an L-type (levamisole and pyrantel) agonist: classification of cholinergic anthelmintics in Ascaris.	2004 Aug	15313135
New class of potent catalysts of O2.-dismutation. Mn(III) ortho-methoxyethylpyridyl- and di-ortho-methoxyethylimidazolylporphyrins.	2004 Jun 7	15252564
Contractile activity and motility responses of the dog heartworm Dirofilaria immitis to classical anthelmintics and other compounds.	2005 Nov 25	16076531
Microfluidics-enabled method to identify modes of Caenorhabditis elegans paralysis in four anthelmintics.	2013	24396537

Patents

Sample Use Guides

In Vivo Use Guide

Sheep and cattle: 200 mg per kg

Route of Administration: Other

In Vitro Use Guide

Methyridine 10(-3) M produced partial neuromuscular block in rat isolated phrenic nerve-diaphragm, which was not affected by a tetanus or by potassium or eserine.

Name

Type

Language

METHYRIDINE SULFATE

Common Name

English

METYRIDINE SULFATE

Common Name

English

PYRIDINE, 2-(2-METHOXYETHYL)-, SULFATE

Systematic Name

English

Code System Code Type Description

ECHA (EC/EINECS)

275-884-6