U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ABSOLUTE
Molecular Formula C14H9ClF3NO2
Molecular Weight 315.675
Optical Activity UNSPECIFIED
Defined Stereocenters 1 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of EFAVIRENZ

SMILES

FC(F)(F)[C@]1(OC(=O)NC2=CC=C(Cl)C=C12)C#CC3CC3

InChI

InChIKey=XPOQHMRABVBWPR-ZDUSSCGKSA-N
InChI=1S/C14H9ClF3NO2/c15-9-3-4-11-10(7-9)13(14(16,17)18,21-12(20)19-11)6-5-8-1-2-8/h3-4,7-8H,1-2H2,(H,19,20)/t13-/m0/s1

HIDE SMILES / InChI

Description

Efavirenz (brand names Sustiva® and Stocrin®) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) and is used as part of highly active antiretroviral therapy (HAART) for the treatment of a human immunodeficiency virus (HIV) type 1. For HIV infection that has not previously been treated, efavirenz and lamivudine in combination with zidovudine or tenofovir is the preferred NNRTI-based regimen. Efavirenz is also used in combination with other antiretroviral agents as part of an expanded postexposure prophylaxis regimen to prevent HIV transmission for those exposed to materials associated with a high risk for HIV transmission.

CNS Activity

Originator

Approval Year

PubMed

PubMed

TitleDatePubMed
Antiretrovirals: simultaneous determination of five protease inhibitors and three nonnucleoside transcriptase inhibitors in human plasma by a rapid high-performance liquid chromatography--mass spectrometry assay.
2001 Aug
Antiviral drugs: current state of the art.
2001 Aug
Protease-sparing regimen in a real-life practice with naïve patients: an equal opportunity approach?
2001 Jan-Feb
[Drug interactions with antiretroviral agents].
2001 May-Jun
Other issues: penetration into sanctuary sites, immune reconstitution and NNRTI sequencing.
2001 Nov
Factors affecting adherence and convenience in antiretroviral therapy.
2001 Nov
Comparison of NNRTIs in antiretroviral-experienced patients.
2001 Nov
Comparison of NNRTIs in antiretroviral-naïve patients.
2001 Nov
The role of NNRTIs in antiretroviral combination therapy: an introduction.
2001 Nov
Thiosugars. VIII. Preparation of new 4'-thio-L-lyxo pyrimidine nucleoside analogues.
2001 Sep
Efavirenz-induced psychosis.
2001 Sep 28
Response to first protease inhibitor- and efavirenz-containing antiretroviral combination therapy. The Swiss HIV Cohort Study.
2001 Sep 28
Structural mechanisms of drug resistance for mutations at codons 181 and 188 in HIV-1 reverse transcriptase and the improved resilience of second generation non-nucleoside inhibitors.
2001 Sep 28
Patents

Sample Use Guides

In Vivo Use Guide
SUSTIVA should be taken orally once daily on an empty stomach, preferably at bedtime. • Recommended adult dose: 600 mg. • With voriconazole, increase voriconazole maintenance dose to 400 mg every 12 hours and decrease SUSTIVA dose to 300 mg once daily using the capsule formulation.
Route of Administration: Oral
In Vitro Use Guide
10 pM efavirenz completely inhibited 0.5 U HIV RT.
Name Type Language
EFAVIRENZ
EMA EPAR   HSDB   INN   JAN   MART.   MI   ORANGE BOOK   USP-RS   VANDF   WHO-DD   WHO-IP  
INN  
Official Name English
SUSTIVA
Brand Name English
(S)-6-CHLORO-4-(CYCLOPROPYLETHYNYL)-1,4-DIHYDRO-4-(TRIFLUOROMETHYL)-2H-3,1-BENZOXAZIN-2-ONE
Systematic Name English
EFAVIRENZ [EMA EPAR]
Common Name English
EFAVIRENZ [MI]
Common Name English
EFAVIRENZ [VANDF]
Common Name English
EFAVIRENZ [ORANGE BOOK]
Common Name English
EFAVIRENZ [WHO-IP]
Common Name English
EFAVIRENZ [WHO-DD]
Common Name English
EFAVIRENZUM [WHO-IP LATIN]
Common Name English
EFAVIRENZ [HSDB]
Common Name English
EFAVIRENZ [JAN]
Common Name English
VIRADAY
Brand Name English
EFAVIRENZ [INN]
Common Name English
TELURA COMPONENT EFAVIRENZ
Common Name English
STOCRIN
Brand Name English
EFAVIRENZ [USP-RS]
Common Name English
EFAVIRENZ TEVA
Brand Name English
EFV
Common Name English
EFAVIRENZ [MART.]
Common Name English
EFAVIRENZ COMPONENT OF ATRIPLA
Common Name English
ATRIPLA COMPONENT EFAVIRENZ
Common Name English
Classification Tree Code System Code
NDF-RT N0000009948
Created by admin on Mon Oct 21 19:49:24 UTC 2019 , Edited by admin on Mon Oct 21 19:49:24 UTC 2019
LIVERTOX 341
Created by admin on Mon Oct 21 19:49:24 UTC 2019 , Edited by admin on Mon Oct 21 19:49:24 UTC 2019
WHO-ATC J05AR11
Created by admin on Mon Oct 21 19:49:24 UTC 2019 , Edited by admin on Mon Oct 21 19:49:24 UTC 2019
NDF-RT N0000175460
Created by admin on Mon Oct 21 19:49:24 UTC 2019 , Edited by admin on Mon Oct 21 19:49:24 UTC 2019
EMA ASSESSMENT REPORTS SUSTIVA (AUTHORIZED: HIV INFECTIONS)
Created by admin on Mon Oct 21 19:49:24 UTC 2019 , Edited by admin on Mon Oct 21 19:49:24 UTC 2019
EMA ASSESSMENT REPORTS ATRIPLA (AUTHORIZED: HIV INFECTIONS)
Created by admin on Mon Oct 21 19:49:24 UTC 2019 , Edited by admin on Mon Oct 21 19:49:24 UTC 2019
NDF-RT N0000175463
Created by admin on Mon Oct 21 19:49:24 UTC 2019 , Edited by admin on Mon Oct 21 19:49:24 UTC 2019
WHO-ESSENTIAL MEDICINES LIST 6.4.2.3 (EFV/FTC/TEN)
Created by admin on Mon Oct 21 19:49:24 UTC 2019 , Edited by admin on Mon Oct 21 19:49:24 UTC 2019
WHO-VATC QJ05AR11
Created by admin on Mon Oct 21 19:49:24 UTC 2019 , Edited by admin on Mon Oct 21 19:49:24 UTC 2019
WHO-ATC J05AR06
Created by admin on Mon Oct 21 19:49:24 UTC 2019 , Edited by admin on Mon Oct 21 19:49:24 UTC 2019
WHO-VATC QJ05AR06
Created by admin on Mon Oct 21 19:49:24 UTC 2019 , Edited by admin on Mon Oct 21 19:49:24 UTC 2019
WHO-ESSENTIAL MEDICINES LIST 6.4.2.2
Created by admin on Mon Oct 21 19:49:24 UTC 2019 , Edited by admin on Mon Oct 21 19:49:24 UTC 2019
NCI_THESAURUS C97453
Created by admin on Mon Oct 21 19:49:24 UTC 2019 , Edited by admin on Mon Oct 21 19:49:24 UTC 2019
WHO-VATC QJ05AG03
Created by admin on Mon Oct 21 19:49:24 UTC 2019 , Edited by admin on Mon Oct 21 19:49:24 UTC 2019
WHO-ATC J05AG03
Created by admin on Mon Oct 21 19:49:24 UTC 2019 , Edited by admin on Mon Oct 21 19:49:24 UTC 2019
EMA ASSESSMENT REPORTS STOCRIN (AUTHORIZED: HIV INFECTIONS)
Created by admin on Mon Oct 21 19:49:24 UTC 2019 , Edited by admin on Mon Oct 21 19:49:24 UTC 2019
EMA ASSESSMENT REPORTS EFAVIRENZ TEVA (AUTHORIZED: HIV INFECTIONS)
Created by admin on Mon Oct 21 19:49:24 UTC 2019 , Edited by admin on Mon Oct 21 19:49:24 UTC 2019
Code System Code Type Description
NDF-RT
N0000182140
Created by admin on Mon Oct 21 19:49:24 UTC 2019 , Edited by admin on Mon Oct 21 19:49:24 UTC 2019
PRIMARY Cytochrome P450 2C19 Inhibitors [MoA]
ChEMBL
CHEMBL223228
Created by admin on Mon Oct 21 19:49:24 UTC 2019 , Edited by admin on Mon Oct 21 19:49:24 UTC 2019
PRIMARY
EPA CompTox
154598-52-4
Created by admin on Mon Oct 21 19:49:24 UTC 2019 , Edited by admin on Mon Oct 21 19:49:24 UTC 2019
PRIMARY
WHO INTERNATIONAL PHARMACOPEIA
EFAVIRENZ
Created by admin on Mon Oct 21 19:49:24 UTC 2019 , Edited by admin on Mon Oct 21 19:49:24 UTC 2019
PRIMARY Description: White to slightly pink powder.Solubility: Practically insoluble in water, freely soluble in methanol.Category. Antiretroviral (Non-nucleoside Reverse Transcriptase Inhibitor).Storage. Efavirenz should be kept in a well-closed container, protected from light.Additional information: Efavirenz may exhibit polymorphism.Requirements: Definition: Efavirenz contains not less than 97.0% and not more than 103.0% of C14H9ClF3NO2, calculated with reference to thedried substance.Manufacture: The production method is validated to ensure that the substance is the (4S)-enantiomer.
EVMPD
SUB06463MIG
Created by admin on Mon Oct 21 19:49:24 UTC 2019 , Edited by admin on Mon Oct 21 19:49:24 UTC 2019
PRIMARY
PUBCHEM
64139
Created by admin on Mon Oct 21 19:49:24 UTC 2019 , Edited by admin on Mon Oct 21 19:49:24 UTC 2019
PRIMARY
MESH
C098320
Created by admin on Mon Oct 21 19:49:24 UTC 2019 , Edited by admin on Mon Oct 21 19:49:24 UTC 2019
PRIMARY
RXCUI
195085
Created by admin on Mon Oct 21 19:49:24 UTC 2019 , Edited by admin on Mon Oct 21 19:49:24 UTC 2019
PRIMARY RxNorm
NDF-RT
N0000182141
Created by admin on Mon Oct 21 19:49:24 UTC 2019 , Edited by admin on Mon Oct 21 19:49:24 UTC 2019
PRIMARY Cytochrome P450 3A4 Inhibitors [MoA]
MERCK INDEX
M4839
Created by admin on Mon Oct 21 19:49:24 UTC 2019 , Edited by admin on Mon Oct 21 19:49:24 UTC 2019
PRIMARY Merck Index
HSDB
154598-52-4
Created by admin on Mon Oct 21 19:49:24 UTC 2019 , Edited by admin on Mon Oct 21 19:49:24 UTC 2019
PRIMARY
INN
7718
Created by admin on Mon Oct 21 19:49:24 UTC 2019 , Edited by admin on Mon Oct 21 19:49:24 UTC 2019
PRIMARY
NCI_THESAURUS
C29027
Created by admin on Mon Oct 21 19:49:24 UTC 2019 , Edited by admin on Mon Oct 21 19:49:24 UTC 2019
PRIMARY
WIKIPEDIA
EFAVIRENZ
Created by admin on Mon Oct 21 19:49:24 UTC 2019 , Edited by admin on Mon Oct 21 19:49:24 UTC 2019
PRIMARY
NDF-RT
N0000185504
Created by admin on Mon Oct 21 19:49:24 UTC 2019 , Edited by admin on Mon Oct 21 19:49:24 UTC 2019
PRIMARY Cytochrome P450 2C9 Inhibitors [MoA]
NDF-RT
N0000187064
Created by admin on Mon Oct 21 19:49:24 UTC 2019 , Edited by admin on Mon Oct 21 19:49:24 UTC 2019
PRIMARY Cytochrome P450 2B6 Inducers [MoA]
CAS
154598-52-4
Created by admin on Mon Oct 21 19:49:24 UTC 2019 , Edited by admin on Mon Oct 21 19:49:24 UTC 2019
PRIMARY
DRUG BANK
DB00625
Created by admin on Mon Oct 21 19:49:24 UTC 2019 , Edited by admin on Mon Oct 21 19:49:24 UTC 2019
PRIMARY
NDF-RT
N0000190118
Created by admin on Mon Oct 21 19:49:24 UTC 2019 , Edited by admin on Mon Oct 21 19:49:24 UTC 2019
PRIMARY Cytochrome P450 3A Inducers [MoA]