Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C20H28N2O |
| Molecular Weight | 312.4491 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
C(CN1CCCCC1)C#CC2=CC(CN3CCOCC3)=CC=C2
InChI
InChIKey=HDRIBIYPLKZUDQ-UHFFFAOYSA-N
InChI=1S/C20H28N2O/c1-3-10-21(11-4-1)12-5-2-7-19-8-6-9-20(17-19)18-22-13-15-23-16-14-22/h6,8-9,17H,1,3-5,10-16,18H2
JNJ-10181457 is a histamine H3 receptor antagonist, which was developed by Johnson & Johnson. Selective blockade of histamine H3 receptors might have therapeutic utility for the treatment of working memory deficits and learning disorders, especially those in which ACh neurotransmission is compromised.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Diamine-based human histamine H3 receptor antagonists: (4-aminobutyn-1-yl)benzylamines. | 2009-10 |
|
| JNJ-10181457, a selective non-imidazole histamine H(3) receptor antagonist, normalizes acetylcholine neurotransmission and has efficacy in translational rat models of cognition. | 2009-06 |
|
| Radiosynthesis and biodistribution of a histamine H3 receptor antagonist 4-[3-(4-piperidin-1-yl-but-1-ynyl)-[11C]benzyl]-morpholine: evaluation of a potential PET ligand. | 2006-08 |
Patents
| Name | Type | Language | ||
|---|---|---|---|---|
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Preferred Name | English | ||
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Common Name | English | ||
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Systematic Name | English | ||
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Systematic Name | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
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9944610
Created by
admin on Mon Mar 31 22:11:57 GMT 2025 , Edited by admin on Mon Mar 31 22:11:57 GMT 2025
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PRIMARY | |||
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544707-19-9
Created by
admin on Mon Mar 31 22:11:57 GMT 2025 , Edited by admin on Mon Mar 31 22:11:57 GMT 2025
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PRIMARY | |||
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1188547-18-3
Created by
admin on Mon Mar 31 22:11:57 GMT 2025 , Edited by admin on Mon Mar 31 22:11:57 GMT 2025
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SUPERSEDED | |||
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JD270971QC
Created by
admin on Mon Mar 31 22:11:57 GMT 2025 , Edited by admin on Mon Mar 31 22:11:57 GMT 2025
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PRIMARY |
ACTIVE MOIETY
