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Details

Stereochemistry ACHIRAL
Molecular Formula C13H17Br2NO2.ClH
Molecular Weight 415.549
Optical Activity UNSPECIFIED
Defined Stereocenters 2 / 2
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of DEMBREXINE HYDROCHLORIDE

SMILES

Cl.O[C@H]1CC[C@@H](CC1)NCC2=C(O)C(Br)=CC(Br)=C2

InChI

InChIKey=BGRWLVRJIPTKQW-PFWPSKEQSA-N
InChI=1S/C13H17Br2NO2.ClH/c14-9-5-8(13(18)12(15)6-9)7-16-10-1-3-11(17)4-2-10;/h5-6,10-11,16-18H,1-4,7H2;1H/t10-,11-;

HIDE SMILES / InChI

Description

Dembrexine is a mucolytic agent which reduces the viscosity of respiratory mucus. It improves movement of mucus in small airways. Dembrexine increases secretion of the serous cells in the glands of the nasal, tracheal and bronchial cells and in type II alveolar cells. It also possesses an anti-tussive effect. Dembrexine is used in the treatment of respiratory disease in horses. All respiratory infections with increased secretions. Acute, sub-acute bronchitis. Chronic respiratory disease. Infection of the upper airways.

Originator

Approval Year

Targets

Primary TargetPharmacologyConditionPotency

Conditions

ConditionModalityTargetsHighest PhaseProduct
Palliative
Sputolosin
Palliative
Sputolosin
Palliative
Sputolosin
Palliative
Sputolosin

PubMed

Sample Use Guides

In Vivo Use Guide
Twice daily administration of 0.3 mg active ingredient per kg bodyweight. Adult horses (500 kg): 30 g powder twice daily in the food. Small horses, ponies and foals: 10 g powder per 170 kg bodyweight twice daily.
Route of Administration: Oral
In Vitro Use Guide
Unknown