U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ABSOLUTE
Molecular Formula C24H32O6
Molecular Weight 416.5073
Optical Activity UNSPECIFIED
Defined Stereocenters 8 / 8
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of DESONIDE

SMILES

CC1(C)O[C@@H]2C[C@H]3[C@@H]4CCC5=CC(=O)C=C[C@]5(C)[C@H]4[C@@H](O)C[C@]3(C)[C@@]2(O1)C(=O)CO

InChI

InChIKey=WBGKWQHBNHJJPZ-LECWWXJVSA-N
InChI=1S/C24H32O6/c1-21(2)29-19-10-16-15-6-5-13-9-14(26)7-8-22(13,3)20(15)17(27)11-23(16,4)24(19,30-21)18(28)12-25/h7-9,15-17,19-20,25,27H,5-6,10-12H2,1-4H3/t15-,16-,17-,19+,20+,22-,23-,24+/m0/s1

HIDE SMILES / InChI

Description

Desonide is a topical glucocorticoid which was approved by FDA for the treatment of such conditions as eczema, psoriasis, atopic dermatitis, etc. The exact mechanism of drug action is unknown.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
DESONIDE
Primary
DESONIDE
Primary
DESONIDE
Primary
DESONIDE
Primary
DESONIDE
PubMed

PubMed

TitleDatePubMed
Clinical comparison of alclometasone dipropionate and desonide ointments (0.05%) in the management of psoriasis.
1982
Allergic contact dermatitis from topical corticosteroids.
1989 Aug
Corticosteroid therapy in the treatment of pediatric patients with atopic dermatitis.
2007 Sep 20
Fixed drug eruption induced by atenolol.
2009 Apr 24
Rhabdomyomatous mesenchymal hamartoma: clinical overview and report of a case with spontaneous regression.
2009 Dec
Treatment of scalp and facial seborrheic dermatitis with desonide hydrogel 0.05%.
2009 Feb
Drugs associated with more suicidal ideations are also associated with more suicide attempts.
2009 Oct 2
Vitiligo after diphencyprone for alopecia areata.
2010
Good adherence and early efficacy using desonide hydrogel for atopic dermatitis: results from a program addressing patient compliance.
2010 Apr
Update on the management of chronic eczema: new approaches and emerging treatment options.
2010 Jul 28
Pediatric atopic dermatitis: a review of the medical management.
2010 Sep
Patents

Sample Use Guides

In Vivo Use Guide
Desonide Cream, 0.05% should be applied to the affected area as a thin film two to four times daily depending on the severity of the condition.
Route of Administration: Topical
Name Type Language
DESONIDE
INN   MART.   MI   ORANGE BOOK   USAN   USP-RS   VANDF   WHO-DD  
USAN   INN  
Official Name English
DESONIDE [MART.]
Common Name English
DESONIDE COMPONENT OF TRIDESILON
Common Name English
DESONIDE [ORANGE BOOK]
Common Name English
TRIDESILON COMPONENT DESONIDE
Common Name English
DESONIDE [USAN]
Common Name English
PREGNA-1,4-DIENE-3,20-DIONE, 11,21-DIHYDROXY-16,17-((1-METHYLETHYLIDENE)BIS(OXY))-, (11.BETA.,16.ALPHA.)-
Common Name English
VERDESO
Brand Name English
11.BETA.,16.ALPHA.,17,21-TETRAHYDROXYPREGNA-1,4-DIENE-3,20-DIONE CYCLIC 16,17-ACETAL WITH ACETONE
Common Name English
DESOWEN
Brand Name English
DESONIDE [USP-RS]
Common Name English
D-2083
Code English
DESONIDE [VANDF]
Common Name English
D2083
Code English
DESONIDE [INN]
Common Name English
DESONIDE [MI]
Common Name English
DESONIDE [WHO-DD]
Common Name English
DESONATE
Brand Name English
Classification Tree Code System Code
WHO-ATC S01BA11
Created by admin on Tue Mar 06 11:20:40 UTC 2018 , Edited by admin on Tue Mar 06 11:20:40 UTC 2018
NDF-RT N0000175450
Created by admin on Tue Mar 06 11:20:40 UTC 2018 , Edited by admin on Tue Mar 06 11:20:40 UTC 2018
WHO-VATC QS01BA11
Created by admin on Tue Mar 06 11:20:40 UTC 2018 , Edited by admin on Tue Mar 06 11:20:40 UTC 2018
WHO-ATC D07BB02
Created by admin on Tue Mar 06 11:20:40 UTC 2018 , Edited by admin on Tue Mar 06 11:20:40 UTC 2018
WHO-VATC QD07BB02
Created by admin on Tue Mar 06 11:20:40 UTC 2018 , Edited by admin on Tue Mar 06 11:20:40 UTC 2018
WHO-ATC D07AB08
Created by admin on Tue Mar 06 11:20:40 UTC 2018 , Edited by admin on Tue Mar 06 11:20:40 UTC 2018
WHO-VATC QD07AB08
Created by admin on Tue Mar 06 11:20:40 UTC 2018 , Edited by admin on Tue Mar 06 11:20:40 UTC 2018
NDF-RT N0000175576
Created by admin on Tue Mar 06 11:20:40 UTC 2018 , Edited by admin on Tue Mar 06 11:20:40 UTC 2018
Code System Code Type Description
EPA CompTox
638-94-8
Created by admin on Tue Mar 06 11:20:40 UTC 2018 , Edited by admin on Tue Mar 06 11:20:40 UTC 2018
PRIMARY
CAS
638-94-8
Created by admin on Tue Mar 06 11:20:40 UTC 2018 , Edited by admin on Tue Mar 06 11:20:40 UTC 2018
PRIMARY
ChEMBL
CHEMBL1201109
Created by admin on Tue Mar 06 11:20:40 UTC 2018 , Edited by admin on Tue Mar 06 11:20:40 UTC 2018
PRIMARY
IUPHAR
7066
Created by admin on Tue Mar 06 11:20:40 UTC 2018 , Edited by admin on Tue Mar 06 11:20:40 UTC 2018
PRIMARY
LactMed
638-94-8
Created by admin on Tue Mar 06 11:20:40 UTC 2018 , Edited by admin on Tue Mar 06 11:20:40 UTC 2018
PRIMARY
WIKIPEDIA
DESONIDE
Created by admin on Tue Mar 06 11:20:40 UTC 2018 , Edited by admin on Tue Mar 06 11:20:40 UTC 2018
PRIMARY
INN
2889
Created by admin on Tue Mar 06 11:20:40 UTC 2018 , Edited by admin on Tue Mar 06 11:20:40 UTC 2018
PRIMARY
DRUG BANK
DB01260
Created by admin on Tue Mar 06 11:20:40 UTC 2018 , Edited by admin on Tue Mar 06 11:20:40 UTC 2018
PRIMARY
ECHA (EC/EINECS)
211-351-6
Created by admin on Tue Mar 06 11:20:40 UTC 2018 , Edited by admin on Tue Mar 06 11:20:40 UTC 2018
PRIMARY
PUBCHEM
5311066
Created by admin on Tue Mar 06 11:20:40 UTC 2018 , Edited by admin on Tue Mar 06 11:20:40 UTC 2018
PRIMARY SWITZERF
MESH
D003898
Created by admin on Tue Mar 06 11:20:40 UTC 2018 , Edited by admin on Tue Mar 06 11:20:40 UTC 2018
PRIMARY
EVMPD
SUB07005MIG
Created by admin on Tue Mar 06 11:20:40 UTC 2018 , Edited by admin on Tue Mar 06 11:20:40 UTC 2018
PRIMARY
RXCUI
3254
Created by admin on Tue Mar 06 11:20:40 UTC 2018 , Edited by admin on Tue Mar 06 11:20:40 UTC 2018
PRIMARY RxNorm
NCI_THESAURUS
C61702
Created by admin on Tue Mar 06 11:20:40 UTC 2018 , Edited by admin on Tue Mar 06 11:20:40 UTC 2018
PRIMARY
MERCK INDEX
M4199
Created by admin on Tue Mar 06 11:20:40 UTC 2018 , Edited by admin on Tue Mar 06 11:20:40 UTC 2018
PRIMARY Merck Index