FLORTAUCIPIR

Investigational

Details

Stereochemistry	ACHIRAL
Molecular Formula	C16H10FN3
Molecular Weight	263.2691
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

FC1=CC=C(C=N1)C2=CC=C3C(NC4=C3C=NC=C4)=C2

InChI

InChIKey=GETAAWDSFUCLBS-UHFFFAOYSA-N

InChI=1S/C16H10FN3/c17-16-4-2-11(8-19-16)10-1-3-12-13-9-18-6-5-14(13)20-15(12)7-10/h1-9,20H

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/31009046 | https://www.ncbi.nlm.nih.gov/pubmed/30988363 | https://www.ncbi.nlm.nih.gov/pubmed/30594046

FLORTAUCIPIR is a gamma-carboline derivative. Its 18F radiolabelled form is a highly selective positron emission tomography (PET) tracer targeting paired helical filament (PHF)-tau in the brain. This tracer is studying for clinical assessment in patients with various tauopathies, including Alzheimer's disease.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Microtubule-associated protein tau 4 Target ID: CHEMBL1293224 Sources: https://www.ncbi.nlm.nih.gov/pubmed/28219440 \| https://www.ncbi.nlm.nih.gov/pubmed/23411393	Binding Agent 1076		14.6 nM [Kd]

PubMed

Title	Date	PubMed
A multicentre longitudinal study of flortaucipir (18F) in normal ageing, mild cognitive impairment and Alzheimer's disease dementia.	2019-06-01	31009046
18F-Flortaucipir in TDP-43 associated frontotemporal dementia.	2019-04-15	30988363
18F-flortaucipir uptake patterns in clinical subtypes of primary progressive aphasia.	2019-03	30594046
[(18)F]T807, a novel tau positron emission tomography imaging agent for Alzheimer's disease.	2013-11	23411393

Name

Type

Language

FLORTAUCIPIR

Common Name

English

T-807

Preferred Name

English

T807

Code

English

7-(6-FLUOROPYRIDIN-3-YL)-5H-PYRIDO(4,3-B)INDOLE

Systematic Name

English

5H-PYRIDO(4,3-B)INDOLE, 7-(6-FLUORO-3-PYRIDINYL)-

Systematic Name

English

Code System Code Type Description

EVMPD

SUB184666