FLORTAUCIPIR

Investigational

Details

Stereochemistry	ACHIRAL
Molecular Formula	C16H10FN3
Molecular Weight	263.2691
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

FC1=NC=C(C=C1)C2=CC3=C(C=C2)C4=C(N3)C=CN=C4

InChI

InChIKey=GETAAWDSFUCLBS-UHFFFAOYSA-N

InChI=1S/C16H10FN3/c17-16-4-2-11(8-19-16)10-1-3-12-13-9-18-6-5-14(13)20-15(12)7-10/h1-9,20H

HIDE SMILES / InChI

Molecular Formula	C16H10FN3
Molecular Weight	263.2691
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/31009046 | https://www.ncbi.nlm.nih.gov/pubmed/30988363 | https://www.ncbi.nlm.nih.gov/pubmed/30594046

FLORTAUCIPIR is a gamma-carboline derivative. Its 18F radiolabelled form is a highly selective positron emission tomography (PET) tracer targeting paired helical filament (PHF)-tau in the brain. This tracer is studying for clinical assessment in patients with various tauopathies, including Alzheimer's disease.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Microtubule-associated protein tau 4 Target ID: CHEMBL1293224 Sources: https://www.ncbi.nlm.nih.gov/pubmed/28219440 \| https://www.ncbi.nlm.nih.gov/pubmed/23411393	Binding Agent 1064		14.6 nM [Kd]

PubMed

Title	Date	PubMed
[(18)F]T807, a novel tau positron emission tomography imaging agent for Alzheimer's disease.	2013 Nov	23411393
(18)F-Flortaucipir in TDP-43 associated frontotemporal dementia.	2019 Apr 15	30988363
A multicentre longitudinal study of flortaucipir (18F) in normal ageing, mild cognitive impairment and Alzheimer's disease dementia.	2019 Jun 1	31009046
(18)F-flortaucipir uptake patterns in clinical subtypes of primary progressive aphasia.	2019 Mar	30594046

Substance Class	Chemical Created by `admin` on `Sat Dec 16 08:10:00 GMT 2023` Edited by `admin` on `Sat Dec 16 08:10:00 GMT 2023`
Record UNII	J09QS3Z3WB
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

FLORTAUCIPIR

Common Name

English

T807

Code

English

7-(6-FLUOROPYRIDIN-3-YL)-5H-PYRIDO(4,3-B)INDOLE

Systematic Name

English

T-807

Code

English

5H-PYRIDO(4,3-B)INDOLE, 7-(6-FLUORO-3-PYRIDINYL)-

Systematic Name

English

Code System Code Type Description

EVMPD

SUB184666