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Details

Stereochemistry ACHIRAL
Molecular Formula C16H10FN3
Molecular Weight 263.2691
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of FLORTAUCIPIR

SMILES

FC1=NC=C(C=C1)C2=CC3=C(C=C2)C4=C(N3)C=CN=C4

InChI

InChIKey=GETAAWDSFUCLBS-UHFFFAOYSA-N
InChI=1S/C16H10FN3/c17-16-4-2-11(8-19-16)10-1-3-12-13-9-18-6-5-14(13)20-15(12)7-10/h1-9,20H

HIDE SMILES / InChI

Molecular Formula C16H10FN3
Molecular Weight 263.2691
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

FLORTAUCIPIR is a gamma-carboline derivative. Its 18F radiolabelled form is a highly selective positron emission tomography (PET) tracer targeting paired helical filament (PHF)-tau in the brain. This tracer is studying for clinical assessment in patients with various tauopathies, including Alzheimer's disease.

Originator

Approval Year

Targets

Primary TargetPharmacologyConditionPotency
14.6 nM [Kd]

PubMed

Substance Class Chemical
Record UNII
J09QS3Z3WB
Record Status Validated (UNII)
Record Version