TELINAVIR

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C33H44N6O5
Molecular Weight	604.7397
Optical Activity	UNSPECIFIED
Defined Stereocenters	3 / 3
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC(C)CN(C[C@@H](O)[C@H](CC1=CC=CC=C1)NC(=O)[C@H](CC(N)=O)NC(=O)C2=NC3=CC=CC=C3C=C2)C(=O)NC(C)(C)C

InChI

InChIKey=ZILOOGIOHVCEKS-HZFUHODCSA-N

InChI=1S/C33H44N6O5/c1-21(2)19-39(32(44)38-33(3,4)5)20-28(40)26(17-22-11-7-6-8-12-22)36-31(43)27(18-29(34)41)37-30(42)25-16-15-23-13-9-10-14-24(23)35-25/h6-16,21,26-28,40H,17-20H2,1-5H3,(H2,34,41)(H,36,43)(H,37,42)(H,38,44)/t26-,27-,28+/m0/s1

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/9215651 | https://www.ncbi.nlm.nih.gov/pubmed/8619573

Telinavir (previously known as SC-52151) was developed as an anti-HIV aspartyl protease inhibitor for the treatment of HIV Infections. Telinavir participated in Phase I/II clinical study. In spite of the drug was well tolerated no antiviral activity was produced and further development of the drug was discontinued.

Approval Year

PubMed

Title	Date	PubMed
Characterization of a human immunodeficiency virus type 1 variant with reduced sensitivity to an aminodiol protease inhibitor.	1995 Apr	7884862
In vivo emergence of HIV-1 variants resistant to multiple protease inhibitors.	1995 Apr 6	7700387

Sample Use Guides

In Vivo Use Guide

Forty-nine patients received the elixir or self-emulsifying drug delivery system at a dosage of 750 mg three times daily or 1125 mg twice daily for 14 days

Route of Administration: Oral

Name

Type

Language

TELINAVIR

Official Name

English

SC-52151

Code

English

telinavir [INN]

Common Name

English

NSC-670881

Code

English

(2S)-N-[(1S,2R)-1-Benzyl-3-(3-tert-butyl-1-isobutylureido)-2-hydroxypropyl]-2-quinaldamidosuccinamide

Systematic Name

English

N-(3-((((1,1-DIMETHYLETHYL)AMINO)CARBONYL)(2-METHYLPROPYL)-AMINO)-2R-HYDROXY-1S-(PHENYLMETHYL)PROPYL)-2S-((2-QUINOLINYLCARBONYL)AMINO)BUTANEDIAMIDE

Systematic Name

English

BUTANEDIAMIDE, N1-((1S,2R)-3-((((1,1-DIMETHYLETHYL)AMINO)CARBONYL)(2-METHYLPROPYL)AMINO)-2-HYDROXY-1-(PHENYLMETHYL)PROPYL)-2-((2-QUINOLINYLCARBONYL)AMINO)-, (2S)-

Systematic Name

English

TELINAVIR [USAN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C97366