Details
| Stereochemistry | RACEMIC |
| Molecular Formula | C6H6Cl6 |
| Molecular Weight | 290.83 |
| Optical Activity | ( + / - ) |
| Defined Stereocenters | 6 / 6 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl[C@H]1[C@H](Cl)[C@H](Cl)[C@@H](Cl)[C@H](Cl)[C@H]1Cl
InChI
InChIKey=JLYXXMFPNIAWKQ-LKPKBOIGSA-N
InChI=1S/C6H6Cl6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-6H/t1-,2-,3-,4-,5+,6+/m0/s1
DescriptionCurator's Comment: description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/2431769
Curator's Comment: description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/2431769
α-Hexachlorcyclohexane a byproduct of a production of insecticide lindane (γ-hexachlorocyclohexane). α-Hexachlorcyclohexane is a major (60-70%) component of technical grade hexachlorocyclohexane. It is a widespread environment pollutant and cause liver tumors in rats and mice.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| The elevation of rat liver glutathione-S-transferase activity by alpha-hexachlorocyclohexane. | 1981 Feb 15 |
|
| In vivo and in vitro binding of alpha- and gamma-hexachlorocyclohexane to mouse liver macromolecules. | 1984 Mar |
|
| Carcinogenicity and mode of action evaluation for alpha-hexachlorocyclohexane: Implications for human health risk assessment. | 2016 Apr |
Patents
Sample Use Guides
GABA-A potentiation was measured usin two-electrode voltage-clamp assay. RNA, encoding GABA-A receptors was extracted from rat cerebral cortec and expression in Xenopus oocytes. Effect of Alpha-HCH was studied by chloride currents elicited by 10uM GABA. Application of 10uM alpha-HCH caused increase in response by 200-300 %.
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DTXSID2020684
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206-270-8
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IVM9A2N49K
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319-84-6
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300000024095
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alpha-Hexachlorocyclohexane
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6029
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1367515
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SUBSTANCE RECORD
