Details
Stereochemistry | RACEMIC |
Molecular Formula | C6H6Cl6 |
Molecular Weight | 290.83 |
Optical Activity | ( + / - ) |
Defined Stereocenters | 6 / 6 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl[C@H]1[C@H](Cl)[C@H](Cl)[C@@H](Cl)[C@H](Cl)[C@H]1Cl
InChI
InChIKey=JLYXXMFPNIAWKQ-LKPKBOIGSA-N
InChI=1S/C6H6Cl6/c7-1-2(8)4(10)6(12)5(11)3(1)9/h1-6H/t1-,2-,3-,4-,5+,6+/m0/s1
Molecular Formula | C6H6Cl6 |
Molecular Weight | 290.83 |
Charge | 0 |
Count |
|
Stereochemistry | ABSOLUTE |
Additional Stereochemistry | No |
Defined Stereocenters | 6 / 6 |
E/Z Centers | 0 |
Optical Activity | UNSPECIFIED |
DescriptionSources: https://www.atsdr.cdc.gov/toxprofiles/tp43.pdfCurator's Comment: description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/2431769
Sources: https://www.atsdr.cdc.gov/toxprofiles/tp43.pdf
Curator's Comment: description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/2431769
α-Hexachlorcyclohexane a byproduct of a production of insecticide lindane (γ-hexachlorocyclohexane). α-Hexachlorcyclohexane is a major (60-70%) component of technical grade hexachlorocyclohexane. It is a widespread environment pollutant and cause liver tumors in rats and mice.
CNS Activity
Sources: https://www.ncbi.nlm.nih.gov/pubmed/83029 | https://www.ncbi.nlm.nih.gov/pubmed/2474221
Curator's Comment: Known to be CNS active in mice; possesses the anti-convulsant and tremorogenic effects of alpha-HCH. Human data not available.
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: CHEMBL1907607 Sources: https://www.ncbi.nlm.nih.gov/pubmed/1377327 |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
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Sample Use Guides
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/1377327
GABA-A potentiation was measured usin two-electrode voltage-clamp assay. RNA, encoding GABA-A receptors was extracted from rat cerebral cortec and expression in Xenopus oocytes. Effect of Alpha-HCH was studied by chloride currents elicited by 10uM GABA. Application of 10uM alpha-HCH caused increase in response by 200-300 %.
Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 05:07:42 GMT 2023
by
admin
on
Sat Dec 16 05:07:42 GMT 2023
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Record UNII |
IVM9A2N49K
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Record Status |
Validated (UNII)
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Record Version |
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-
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DTXSID2020684
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206-270-8
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IVM9A2N49K
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319-84-6
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300000024095
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alpha-Hexachlorocyclohexane
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6029
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1367515
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