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Details

Stereochemistry ABSOLUTE
Molecular Formula C51H72N17O19S5.Na.O.Tc
Molecular Weight 1525.44
Optical Activity UNSPECIFIED
Defined Stereocenters 7 / 7
E/Z Centers 0
Charge -6

SHOW SMILES / InChI
Structure of TECHNETIUM TC-99M APCITIDE

SMILES

[O--].[Na+].[99Tc].CC(=O)NCSC[C@H](NC(=O)CNC(=O)CNC(=O)[C@@H]1CSCC(=O)N[C@H](CC2=CC=C(O)C=C2)C(=O)N[C@@H](CSCCCN)C(=O)NCC(=O)N[C@@H](CC([O-])=O)C(=O)N1)C(=O)NCC(=O)N[C@@H](CSCNC(C)=O)C(=O)[N-]CC(=O)[N-]CC(=O)[N-][C@@H](C[S-])C(N)=O

InChI

InChIKey=ORRQNYHHWZZJAG-YLXBGQBVSA-I
InChI=1S/C51H77N17O19S5.Na.O.Tc/c1-26(69)60-24-91-21-33(46(82)56-12-37(72)54-14-39(74)64-32(18-88)45(53)81)66-42(77)17-58-47(83)34(22-92-25-61-27(2)70)65-40(75)15-55-38(73)13-57-49(85)36-20-90-23-43(78)63-30(10-28-4-6-29(71)7-5-28)50(86)67-35(19-89-9-3-8-52)48(84)59-16-41(76)62-31(11-44(79)80)51(87)68-36;;;/h4-7,30-36H,3,8-25,52H2,1-2H3,(H20,53,54,55,56,57,58,59,60,61,62,63,64,65,66,67,68,69,70,71,72,73,74,75,76,77,78,79,80,81,82,83,84,85,86,87,88);;;/q;+1;-2;/p-5/t30-,31+,32+,33+,34+,35+,36+;;;/m1.../s1/i;;;1+1

HIDE SMILES / InChI
Technetium Tc 99m apcitide is a radiopharmaceutical containing a metastable nuclear isomer of technetium-99. Upon radioactive decay with a half-life of 6 hours gamma-rays which can be detected using conventional equipment for X-ray diagnostics. Tc 99m contains the small-molecule synthetic peptide apcitide which binds to the PIIb/IIIa receptors on the surface of activated platelets, which are a major component in active thrombus formation. The localization of radioactivity may be recorded by gamma-ray detection camera. Tc 99m apcitide is indicated for scintigraphic imaging of acute venous thrombosis in the lower extremities in patients with signs and symptoms of acute blood clots. It is marketed by Bayer under tradename AcuTect.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Diagnostic
AcuTect

Approved Use

AcuTect, Kit for the Preparation of Technetium Tc 99m Apcitide Injection, is intended for use in the preparation of technetium Tc 99m apcitide, a diagnostic radiopharmaceutical to be used by intravenous injection.

Launch Date

9.0573118E11
Name Type Language
TECHNETIUM TC-99M APCITIDE
ORANGE BOOK  
Common Name English
TECHNETIUM (99MTC) APCITIDE
INN  
INN  
Official Name English
TECHNETIUM TC-99M APCITIDE [ORANGE BOOK]
Common Name English
(99MTC)-P246
Code English
TECHNETIUM TC 99M APCITIDE
MI   USAN   WHO-DD  
USAN  
Official Name English
99MTC-P246
Code English
TECHNETIUM TC 99M APCITIDE [MI]
Common Name English
technetium (⁹⁹mTc) apcitide [INN]
Common Name English
TECHNETIUM TC 99M APCITIDE [USAN]
Common Name English
Technetium tc 99m apcitide [WHO-DD]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C2124
Created by admin on Fri Dec 15 15:58:13 UTC 2023 , Edited by admin on Fri Dec 15 15:58:13 UTC 2023
NDF-RT N0000000205
Created by admin on Fri Dec 15 15:58:13 UTC 2023 , Edited by admin on Fri Dec 15 15:58:13 UTC 2023
NDF-RT N0000177914
Created by admin on Fri Dec 15 15:58:13 UTC 2023 , Edited by admin on Fri Dec 15 15:58:13 UTC 2023
WHO-ATC V09GA07
Created by admin on Fri Dec 15 15:58:13 UTC 2023 , Edited by admin on Fri Dec 15 15:58:13 UTC 2023
Code System Code Type Description
SMS_ID
100000090381
Created by admin on Fri Dec 15 15:58:13 UTC 2023 , Edited by admin on Fri Dec 15 15:58:13 UTC 2023
PRIMARY
INN
7699
Created by admin on Fri Dec 15 15:58:13 UTC 2023 , Edited by admin on Fri Dec 15 15:58:13 UTC 2023
PRIMARY
EVMPD
SUB10860MIG
Created by admin on Fri Dec 15 15:58:13 UTC 2023 , Edited by admin on Fri Dec 15 15:58:13 UTC 2023
PRIMARY
CAS
178959-14-3
Created by admin on Fri Dec 15 15:58:13 UTC 2023 , Edited by admin on Fri Dec 15 15:58:13 UTC 2023
PRIMARY
ChEMBL
CHEMBL1201524
Created by admin on Fri Dec 15 15:58:13 UTC 2023 , Edited by admin on Fri Dec 15 15:58:13 UTC 2023
PRIMARY
FDA UNII
IV7T84QA4T
Created by admin on Fri Dec 15 15:58:13 UTC 2023 , Edited by admin on Fri Dec 15 15:58:13 UTC 2023
PRIMARY
MERCK INDEX
m10505
Created by admin on Fri Dec 15 15:58:13 UTC 2023 , Edited by admin on Fri Dec 15 15:58:13 UTC 2023
PRIMARY Merck Index
NCI_THESAURUS
C47745
Created by admin on Fri Dec 15 15:58:13 UTC 2023 , Edited by admin on Fri Dec 15 15:58:13 UTC 2023
PRIMARY