TECHNETIUM TC-99M APCITIDE

US Previously Marketed

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C51H72N17O19S5.Na.O.Tc
Molecular Weight	1525.44
Optical Activity	UNSPECIFIED
Defined Stereocenters	7 / 7
E/Z Centers	0
Charge	-6

SHOW SMILES / InChI

Structure Search

SMILES

[O--].[Na+].[99Tc].CC(=O)NCSC[C@H](NC(=O)CNC(=O)CNC(=O)[C@@H]1CSCC(=O)N[C@H](CC2=CC=C(O)C=C2)C(=O)N[C@@H](CSCCCN)C(=O)NCC(=O)N[C@@H](CC([O-])=O)C(=O)N1)C(=O)NCC(=O)N[C@@H](CSCNC(C)=O)C(=O)[N-]CC(=O)[N-]CC(=O)[N-][C@@H](C[S-])C(N)=O

InChI

InChIKey=ORRQNYHHWZZJAG-YLXBGQBVSA-I

InChI=1S/C51H77N17O19S5.Na.O.Tc/c1-26(69)60-24-91-21-33(46(82)56-12-37(72)54-14-39(74)64-32(18-88)45(53)81)66-42(77)17-58-47(83)34(22-92-25-61-27(2)70)65-40(75)15-55-38(73)13-57-49(85)36-20-90-23-43(78)63-30(10-28-4-6-29(71)7-5-28)50(86)67-35(19-89-9-3-8-52)48(84)59-16-41(76)62-31(11-44(79)80)51(87)68-36;;;/h4-7,30-36H,3,8-25,52H2,1-2H3,(H20,53,54,55,56,57,58,59,60,61,62,63,64,65,66,67,68,69,70,71,72,73,74,75,76,77,78,79,80,81,82,83,84,85,86,87,88);;;/q;+1;-2;/p-5/t30-,31+,32+,33+,34+,35+,36+;;;/m1.../s1/i;;;1+1

HIDE SMILES / InChI

Molecular Formula	HO
Molecular Weight	17.0073
Charge	-1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C51H72N17O19S5
Molecular Weight	1387.545
Charge	-5
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	7 / 7
E/Z Centers	8
Optical Activity	UNSPECIFIED

Molecular Formula	Tc
Molecular Weight	98.9063
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	Na
Molecular Weight	22.9898
Charge	1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: http://www.nucleide.org/DDEP_WG/Nuclides/Tc-99m_tables.pdf | https://www.drugs.com/mmx/technetium-tc-99m-apcitide.html | https://adisinsight.springer.com/drugs/800005336

Technetium Tc 99m apcitide is a radiopharmaceutical containing a metastable nuclear isomer of technetium-99. Upon radioactive decay with a half-life of 6 hours gamma-rays which can be detected using conventional equipment for X-ray diagnostics. Tc 99m contains the small-molecule synthetic peptide apcitide which binds to the PIIb/IIIa receptors on the surface of activated platelets, which are a major component in active thrombus formation. The localization of radioactivity may be recorded by gamma-ray detection camera. Tc 99m apcitide is indicated for scintigraphic imaging of acute venous thrombosis in the lower extremities in patients with signs and symptoms of acute blood clots. It is marketed by Bayer under tradename AcuTect.

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Deep Vein Thrombosis 3 Sources: https://www.ncbi.nlm.nih.gov/pubmed/18618107	Diagnostic		Approved 8429	AcuTect Approved Use AcuTect, Kit for the Preparation of Technetium Tc 99m Apcitide Injection, is intended for use in the preparation of technetium Tc 99m apcitide, a diagnostic radiopharmaceutical to be used by intravenous injection. Launch Date 1998

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:58:13 GMT 2023` Edited by `admin` on `Fri Dec 15 15:58:13 GMT 2023`
Record UNII	IV7T84QA4T
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

TECHNETIUM TC-99M APCITIDE

Common Name

English

TECHNETIUM (99MTC) APCITIDE

Official Name

English

TECHNETIUM TC-99M APCITIDE [ORANGE BOOK]

Common Name

English

(99MTC)-P246

Code

English

TECHNETIUM TC 99M APCITIDE

Official Name

English

99MTC-P246

Code

English

TECHNETIUM TC 99M APCITIDE [MI]

Common Name

English

technetium (⁹⁹mTc) apcitide [INN]

Common Name

English

TECHNETIUM TC 99M APCITIDE [USAN]

Common Name

English

Technetium tc 99m apcitide [WHO-DD]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C2124