U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry RACEMIC
Molecular Formula C19H24N2O
Molecular Weight 296.4067
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of AMINOPENTAMIDE

SMILES

CC(CC(C(N)=O)(C1=CC=CC=C1)C2=CC=CC=C2)N(C)C

InChI

InChIKey=NARHAGIVSFTMIG-UHFFFAOYSA-N
InChI=1S/C19H24N2O/c1-15(21(2)3)14-19(18(20)22,16-10-6-4-7-11-16)17-12-8-5-9-13-17/h4-13,15H,14H2,1-3H3,(H2,20,22)

HIDE SMILES / InChI
Aminopentamide is a potent antispasmodic agent. As a cholinergic blocking agent for smooth muscle, its action is similar to atropine. Aminopentamide hydrogen sulfate is marketed under the brand name Centrine indicated in the treatment of acute abdominal visceral spasm, pylorospasm or hypertrophic gastritis and associated nausea, vomiting and/or diarrhea of the dogs and cats. Centrine effectively reduces the tone and amplitude of colonic contractions to a greater degree and for a more extended period than does atropine. Centrine effects a reduction in gastric secretion, a decrease in gastric acidity and a marked decrease in gastric motility. Aminopentamide is a nonselective muscarinic cholinergic .

Approval Year

TargetsConditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Centrine

Approved Use

Centrine is indicated in the treatment of acute abdominal visceral spasm, pylorospasm or hypertrophic gastritis and associated nausea, vomiting and/or diarrhea.

Launch Date

2.1340799E10
PubMed

PubMed

TitleDatePubMed
The pharmacological activity of DL-alpha, alpha-diphenyl, gamma-dimethylaminovaleramide (centrine).
1954 Jan
Some aspects of the pharmacology and clinical application of a parasympatholytic agent, aminopentamide.
1956 Sep 1
[Broncholytic effect of a new synthetic drugs: aminopentamide].
1957 Jun
Patents

Sample Use Guides

Dogs and cats: Administer by subcutaneous or intramuscular injection every 8 to 12 hours as follows: For animals weighing up to 10 pounds (lbs): 0.1 mg; For animals weighing 11 to 20 lbs: 0.2 mg; For animals weighing 21 to 50 lbs: 0.3 mg; For animals weighing 51 to 100 lbs: 0.4 mg; For animals weighing over 100 lbs: 0.5 mg. Dosage may be gradually increased up to a maximum of five times the suggested dosage. Following parenteral use, dosage may be continued by oral administration of tablets.
Route of Administration: Other
A concentration of 0.00005 mg of Aminopentamide per ml of bath fluid was found to reduce the frequency of guinea pig ureteral contractions and a concentration of 0.005 mg/ml virtually stopped contractions.
Name Type Language
AMINOPENTAMIDE
MI  
Common Name English
BENZENEACETAMIDE, .ALPHA.-(2-(DIMETHYLAMINO)PROPYL)-.ALPHA.-PHENYL-
Systematic Name English
VALERAMIDE, 4-(DIMETHYLAMINO)-2,2-DIPHENYL-
Systematic Name English
.ALPHA.-(2-(DIMETHYLAMINO)PROPYL)-.ALPHA.-PHENYLBENZENEACETAMIDE
Systematic Name English
DIMEVAMIDE
INN   MART.   WHO-DD  
INN  
Official Name English
AMINOPENTAMIDE [MI]
Common Name English
NSC-759162
Code English
4-DIMETHYLAMINO-2,2-DIPHENYLVALERAMIDE
Systematic Name English
CENTRINE
Brand Name English
dimevamide [INN]
Common Name English
Dimevamide [WHO-DD]
Common Name English
BL-139
Code English
DIMEVAMIDE [MART.]
Common Name English
Classification Tree Code System Code
CFR 21 CFR 522.62
Created by admin on Sat Dec 16 15:55:48 UTC 2023 , Edited by admin on Sat Dec 16 15:55:48 UTC 2023
CFR 21 CFR 520.62
Created by admin on Sat Dec 16 15:55:48 UTC 2023 , Edited by admin on Sat Dec 16 15:55:48 UTC 2023
NCI_THESAURUS C29704
Created by admin on Sat Dec 16 15:55:48 UTC 2023 , Edited by admin on Sat Dec 16 15:55:48 UTC 2023
Code System Code Type Description
DRUG CENTRAL
170
Created by admin on Sat Dec 16 15:55:48 UTC 2023 , Edited by admin on Sat Dec 16 15:55:48 UTC 2023
PRIMARY
RXCUI
1006397
Created by admin on Sat Dec 16 15:55:48 UTC 2023 , Edited by admin on Sat Dec 16 15:55:48 UTC 2023
PRIMARY RxNorm
ECHA (EC/EINECS)
200-479-8
Created by admin on Sat Dec 16 15:55:48 UTC 2023 , Edited by admin on Sat Dec 16 15:55:48 UTC 2023
PRIMARY
SMS_ID
100000082667
Created by admin on Sat Dec 16 15:55:48 UTC 2023 , Edited by admin on Sat Dec 16 15:55:48 UTC 2023
PRIMARY
CAS
60-46-8
Created by admin on Sat Dec 16 15:55:48 UTC 2023 , Edited by admin on Sat Dec 16 15:55:48 UTC 2023
PRIMARY
PUBCHEM
22565
Created by admin on Sat Dec 16 15:55:48 UTC 2023 , Edited by admin on Sat Dec 16 15:55:48 UTC 2023
PRIMARY
FDA UNII
IP1B47L61M
Created by admin on Sat Dec 16 15:55:48 UTC 2023 , Edited by admin on Sat Dec 16 15:55:48 UTC 2023
PRIMARY
INN
604
Created by admin on Sat Dec 16 15:55:48 UTC 2023 , Edited by admin on Sat Dec 16 15:55:48 UTC 2023
PRIMARY
CAS
5985-87-5
Created by admin on Sat Dec 16 15:55:48 UTC 2023 , Edited by admin on Sat Dec 16 15:55:48 UTC 2023
SUPERSEDED
MERCK INDEX
m1725
Created by admin on Sat Dec 16 15:55:48 UTC 2023 , Edited by admin on Sat Dec 16 15:55:48 UTC 2023
PRIMARY Merck Index
EPA CompTox
DTXSID2057605
Created by admin on Sat Dec 16 15:55:48 UTC 2023 , Edited by admin on Sat Dec 16 15:55:48 UTC 2023
PRIMARY
NSC
759162
Created by admin on Sat Dec 16 15:55:48 UTC 2023 , Edited by admin on Sat Dec 16 15:55:48 UTC 2023
PRIMARY
EVMPD
SUB07184MIG
Created by admin on Sat Dec 16 15:55:48 UTC 2023 , Edited by admin on Sat Dec 16 15:55:48 UTC 2023
PRIMARY
MESH
C012725
Created by admin on Sat Dec 16 15:55:48 UTC 2023 , Edited by admin on Sat Dec 16 15:55:48 UTC 2023
PRIMARY
ChEMBL
CHEMBL92915
Created by admin on Sat Dec 16 15:55:48 UTC 2023 , Edited by admin on Sat Dec 16 15:55:48 UTC 2023
PRIMARY
DAILYMED
IP1B47L61M
Created by admin on Sat Dec 16 15:55:48 UTC 2023 , Edited by admin on Sat Dec 16 15:55:48 UTC 2023
PRIMARY
NCI_THESAURUS
C75273
Created by admin on Sat Dec 16 15:55:48 UTC 2023 , Edited by admin on Sat Dec 16 15:55:48 UTC 2023
PRIMARY
DRUG BANK
DB15597
Created by admin on Sat Dec 16 15:55:48 UTC 2023 , Edited by admin on Sat Dec 16 15:55:48 UTC 2023
PRIMARY