Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C17H24O11 |
Molecular Weight | 404.3659 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 9 / 9 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
[H][C@]12C=C[C@@](O)(CO)[C@@]1([H])[C@H](O[C@]3([H])O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)OC=C2C(=O)OC
InChI
InChIKey=XJMPAUZQVRGFRE-AYDWLWLASA-N
InChI=1S/C17H24O11/c1-25-14(23)8-5-26-15(10-7(8)2-3-17(10,24)6-19)28-16-13(22)12(21)11(20)9(4-18)27-16/h2-3,5,7,9-13,15-16,18-22,24H,4,6H2,1H3/t7-,9-,10-,11-,12+,13-,15+,16+,17-/m1/s1
DescriptionSources: https://www.ncbi.nlm.nih.gov/pubmed/27435384Curator's Comment: Description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/26610473
Sources: https://www.ncbi.nlm.nih.gov/pubmed/27435384
Curator's Comment: Description was created based on several sources, including
https://www.ncbi.nlm.nih.gov/pubmed/26610473
Iridoid glycoside gardenoside is the main effective extraction of Gardenia jasminoides Ellis, which is an indigenous medicinal herb widely used for hepatoprotective, analgesic, and antipyretic drug. Gardenoside was shown to be effective toward HCl/ethanol induced gastric injury in mice and prevents cellular steatosis.
CNS Activity
Sources: https://www.ncbi.nlm.nih.gov/pubmed/25049209
Curator's Comment: gardenoside is CNS active in animals. No human data available.
Approval Year
Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/27435384
mice treated with gardenoside (200 mg/kg) once a day for 2 weeks
Route of Administration:
Oral
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/26610473
Quantities of 30, 40 and 50 µM of Gardenoside were significantly toxic to HepG2 cells. 10 and 20 µM gardenoside has a protective effect on FFA-induced cellular steatosis in HepG2 cells which indicates that Gardenoside might be a potential therapeutic herb against NASH by suppressed supernatant inflammatory cytokine production and intracellular NFkB activity.
Name | Type | Language | ||
---|---|---|---|---|
|
Common Name | English | ||
|
Systematic Name | English | ||
|
Code | English |
Code System | Code | Type | Description | ||
---|---|---|---|---|---|
|
325664
Created by
admin on Sat Dec 16 11:09:12 GMT 2023 , Edited by admin on Sat Dec 16 11:09:12 GMT 2023
|
PRIMARY | |||
|
442423
Created by
admin on Sat Dec 16 11:09:12 GMT 2023 , Edited by admin on Sat Dec 16 11:09:12 GMT 2023
|
PRIMARY | |||
|
DTXSID20947403
Created by
admin on Sat Dec 16 11:09:12 GMT 2023 , Edited by admin on Sat Dec 16 11:09:12 GMT 2023
|
PRIMARY | |||
|
2585534
Created by
admin on Sat Dec 16 11:09:12 GMT 2023 , Edited by admin on Sat Dec 16 11:09:12 GMT 2023
|
PRIMARY | |||
|
INE79XNR2C
Created by
admin on Sat Dec 16 11:09:12 GMT 2023 , Edited by admin on Sat Dec 16 11:09:12 GMT 2023
|
PRIMARY | |||
|
24512-62-7
Created by
admin on Sat Dec 16 11:09:12 GMT 2023 , Edited by admin on Sat Dec 16 11:09:12 GMT 2023
|
PRIMARY | |||
|
INE79XNR2C
Created by
admin on Sat Dec 16 11:09:12 GMT 2023 , Edited by admin on Sat Dec 16 11:09:12 GMT 2023
|
PRIMARY |
SUBSTANCE RECORD