Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C51H81NO12 |
| Molecular Weight | 900.1883 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 15 / 15 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CO[C@@H]1C[C@H](C[C@@H](C)[C@@H]2CC[C@H](C)\C=C(C)\[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)\C=C\C=C\C=C(C)\[C@H](C[C@@H]3CC[C@@H](C)[C@@](O)(O3)C(=O)C(=O)N4CCCC[C@H]4C(=O)O2)OC)CC[C@H]1O
InChI
InChIKey=QFMKPDZCOKCBAQ-NFCVMBANSA-N
InChI=1S/C51H81NO12/c1-31-16-12-11-13-17-33(3)43(60-8)30-39-22-20-37(7)51(59,64-39)48(56)49(57)52-25-15-14-18-40(52)50(58)63-42(34(4)28-38-21-23-41(53)44(29-38)61-9)24-19-32(2)27-36(6)46(55)47(62-10)45(54)35(5)26-31/h11-13,16-17,27,31-32,34-35,37-44,46-47,53,55,59H,14-15,18-26,28-30H2,1-10H3/b13-11+,16-12+,33-17+,36-27+/t31-,32+,34-,35-,37-,38+,39+,40+,41-,42+,43+,44-,46-,47+,51-/m1/s1
Olcorolimus (also known as SAR-943), a 32-deoxo rapamycin was developed as an immunosuppressant that can inhibit proliferation signal via interaction with the mammalian target of rapamycin. It was shown that this drug could have beneficial effect in patients with severe asthma. However, information about the current development of this drug is not available.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Structural identification of SAR-943 metabolites generated by human liver microsomes in vitro using mass spectrometry in combination with analysis of fragmentation patterns. | 2011-07 |
|
| In vivo and in vitro effects of SAR 943, a rapamycin analogue, on airway inflammation and remodeling. | 2003-01-15 |
Patents
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| Code System | Code | Type | Description | ||
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CHEMBL2103865
Created by
admin on Mon Mar 31 21:04:45 GMT 2025 , Edited by admin on Mon Mar 31 21:04:45 GMT 2025
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IGL4DTS8F8
Created by
admin on Mon Mar 31 21:04:45 GMT 2025 , Edited by admin on Mon Mar 31 21:04:45 GMT 2025
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9450
Created by
admin on Mon Mar 31 21:04:45 GMT 2025 , Edited by admin on Mon Mar 31 21:04:45 GMT 2025
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186752-78-3
Created by
admin on Mon Mar 31 21:04:45 GMT 2025 , Edited by admin on Mon Mar 31 21:04:45 GMT 2025
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C170246
Created by
admin on Mon Mar 31 21:04:45 GMT 2025 , Edited by admin on Mon Mar 31 21:04:45 GMT 2025
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XX-130
Created by
admin on Mon Mar 31 21:04:45 GMT 2025 , Edited by admin on Mon Mar 31 21:04:45 GMT 2025
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CHEMBL3545142
Created by
admin on Mon Mar 31 21:04:45 GMT 2025 , Edited by admin on Mon Mar 31 21:04:45 GMT 2025
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300000034269
Created by
admin on Mon Mar 31 21:04:45 GMT 2025 , Edited by admin on Mon Mar 31 21:04:45 GMT 2025
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16663243
Created by
admin on Mon Mar 31 21:04:45 GMT 2025 , Edited by admin on Mon Mar 31 21:04:45 GMT 2025
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PRIMARY |
ACTIVE MOIETY
