Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C51H81NO12 |
| Molecular Weight | 900.1883 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 15 / 15 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[H][C@@]12CC[C@@H](C)[C@@](O)(O1)C(=O)C(=O)N3CCCC[C@@]3([H])C(=O)O[C@@H](CC[C@H](C)\C=C(C)\[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)\C=C\C=C\C=C(C)\[C@H](C2)OC)[C@H](C)C[C@@H]4CC[C@@H](O)[C@@H](C4)OC
InChI
InChIKey=QFMKPDZCOKCBAQ-NFCVMBANSA-N
InChI=1S/C51H81NO12/c1-31-16-12-11-13-17-33(3)43(60-8)30-39-22-20-37(7)51(59,64-39)48(56)49(57)52-25-15-14-18-40(52)50(58)63-42(34(4)28-38-21-23-41(53)44(29-38)61-9)24-19-32(2)27-36(6)46(55)47(62-10)45(54)35(5)26-31/h11-13,16-17,27,31-32,34-35,37-44,46-47,53,55,59H,14-15,18-26,28-30H2,1-10H3/b13-11+,16-12+,33-17+,36-27+/t31-,32+,34-,35-,37-,38+,39+,40+,41-,42+,43+,44-,46-,47+,51-/m1/s1
Olcorolimus (also known as SAR-943), a 32-deoxo rapamycin was developed as an immunosuppressant that can inhibit proliferation signal via interaction with the mammalian target of rapamycin. It was shown that this drug could have beneficial effect in patients with severe asthma. However, information about the current development of this drug is not available.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| In vivo and in vitro effects of SAR 943, a rapamycin analogue, on airway inflammation and remodeling. | 2003 Jan 15 |
|
| Structural identification of SAR-943 metabolites generated by human liver microsomes in vitro using mass spectrometry in combination with analysis of fragmentation patterns. | 2011 Jul |
Patents
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| Code System | Code | Type | Description | ||
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CHEMBL2103865
Created by
admin on Sat Dec 16 01:56:32 GMT 2023 , Edited by admin on Sat Dec 16 01:56:32 GMT 2023
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IGL4DTS8F8
Created by
admin on Sat Dec 16 01:56:32 GMT 2023 , Edited by admin on Sat Dec 16 01:56:32 GMT 2023
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9450
Created by
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186752-78-3
Created by
admin on Sat Dec 16 01:56:32 GMT 2023 , Edited by admin on Sat Dec 16 01:56:32 GMT 2023
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C170246
Created by
admin on Sat Dec 16 01:56:32 GMT 2023 , Edited by admin on Sat Dec 16 01:56:32 GMT 2023
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XX-130
Created by
admin on Sat Dec 16 01:56:32 GMT 2023 , Edited by admin on Sat Dec 16 01:56:32 GMT 2023
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CHEMBL3545142
Created by
admin on Sat Dec 16 01:56:32 GMT 2023 , Edited by admin on Sat Dec 16 01:56:32 GMT 2023
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300000034269
Created by
admin on Sat Dec 16 01:56:32 GMT 2023 , Edited by admin on Sat Dec 16 01:56:32 GMT 2023
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16663243
Created by
admin on Sat Dec 16 01:56:32 GMT 2023 , Edited by admin on Sat Dec 16 01:56:32 GMT 2023
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PRIMARY |
ACTIVE MOIETY
