Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C51H81NO12 |
| Molecular Weight | 900.1883 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 15 / 15 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CO[C@@H]1C[C@H](C[C@@H](C)[C@@H]2CC[C@H](C)\C=C(C)\[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)\C=C\C=C\C=C(C)\[C@H](C[C@@H]3CC[C@@H](C)[C@@](O)(O3)C(=O)C(=O)N4CCCC[C@H]4C(=O)O2)OC)CC[C@H]1O
InChI
InChIKey=QFMKPDZCOKCBAQ-NFCVMBANSA-N
InChI=1S/C51H81NO12/c1-31-16-12-11-13-17-33(3)43(60-8)30-39-22-20-37(7)51(59,64-39)48(56)49(57)52-25-15-14-18-40(52)50(58)63-42(34(4)28-38-21-23-41(53)44(29-38)61-9)24-19-32(2)27-36(6)46(55)47(62-10)45(54)35(5)26-31/h11-13,16-17,27,31-32,34-35,37-44,46-47,53,55,59H,14-15,18-26,28-30H2,1-10H3/b13-11+,16-12+,33-17+,36-27+/t31-,32+,34-,35-,37-,38+,39+,40+,41-,42+,43+,44-,46-,47+,51-/m1/s1
| Molecular Formula | C51H81NO12 |
| Molecular Weight | 900.1883 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 15 / 15 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Olcorolimus (also known as SAR-943), a 32-deoxo rapamycin was developed as an immunosuppressant that can inhibit proliferation signal via interaction with the mammalian target of rapamycin. It was shown that this drug could have beneficial effect in patients with severe asthma. However, information about the current development of this drug is not available.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Structural identification of SAR-943 metabolites generated by human liver microsomes in vitro using mass spectrometry in combination with analysis of fragmentation patterns. | 2011-07 |
|
| In vivo and in vitro effects of SAR 943, a rapamycin analogue, on airway inflammation and remodeling. | 2003-01-15 |
Patents
| Substance Class |
Chemical
Created
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admin
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Edited
Mon Mar 31 21:04:45 GMT 2025
by
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Mon Mar 31 21:04:45 GMT 2025
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| Record UNII |
IGL4DTS8F8
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Validated (UNII)
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CHEMBL2103865
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IGL4DTS8F8
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9450
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186752-78-3
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C170246
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XX-130
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CHEMBL3545142
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300000034269
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16663243
Created by
admin on Mon Mar 31 21:04:45 GMT 2025 , Edited by admin on Mon Mar 31 21:04:45 GMT 2025
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