OLCOROLIMUS

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C51H81NO12
Molecular Weight	900.1883
Optical Activity	UNSPECIFIED
Defined Stereocenters	15 / 15
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[H][C@@]12CC[C@@H](C)[C@@](O)(O1)C(=O)C(=O)N3CCCC[C@@]3([H])C(=O)O[C@@H](CC[C@H](C)\C=C(C)\[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)\C=C\C=C\C=C(C)\[C@H](C2)OC)[C@H](C)C[C@@H]4CC[C@@H](O)[C@@H](C4)OC

InChI

InChIKey=QFMKPDZCOKCBAQ-NFCVMBANSA-N

InChI=1S/C51H81NO12/c1-31-16-12-11-13-17-33(3)43(60-8)30-39-22-20-37(7)51(59,64-39)48(56)49(57)52-25-15-14-18-40(52)50(58)63-42(34(4)28-38-21-23-41(53)44(29-38)61-9)24-19-32(2)27-36(6)46(55)47(62-10)45(54)35(5)26-31/h11-13,16-17,27,31-32,34-35,37-44,46-47,53,55,59H,14-15,18-26,28-30H2,1-10H3/b13-11+,16-12+,33-17+,36-27+/t31-,32+,34-,35-,37-,38+,39+,40+,41-,42+,43+,44-,46-,47+,51-/m1/s1

HIDE SMILES / InChI

Molecular Formula	C51H81NO12
Molecular Weight	900.1883
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	15 / 15
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/21671437 | https://www.ncbi.nlm.nih.gov/pubmed/12406821

Olcorolimus (also known as SAR-943), a 32-deoxo rapamycin was developed as an immunosuppressant that can inhibit proliferation signal via interaction with the mammalian target of rapamycin. It was shown that this drug could have beneficial effect in patients with severe asthma. However, information about the current development of this drug is not available.

Approval Year

PubMed

Title	Date	PubMed
In vivo and in vitro effects of SAR 943, a rapamycin analogue, on airway inflammation and remodeling.	2003 Jan 15	12406821
Structural identification of SAR-943 metabolites generated by human liver microsomes in vitro using mass spectrometry in combination with analysis of fragmentation patterns.	2011 Jul	21671437

Patents

Substance Class	Chemical Created by `admin` on `Sat Dec 16 01:56:32 UTC 2023` Edited by `admin` on `Sat Dec 16 01:56:32 UTC 2023`
Record UNII	IGL4DTS8F8
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

OLCOROLIMUS

Official Name

English

SDZ-227943 N

Code

English

olcorolimus [INN]

Common Name

English

RAPAMYCIN, 27-DEOXO-

Common Name

English

OLCOROLIMUS [USAN]

Common Name

English

SDZ-227-943-N

Code

English

SAR943

Code

English

SDZ 227-943 N

Code

English

SAR-943N

Code

English

SAR-943-NXA

Code

English

COROLIMUS

Brand Name

English

SAR943-NXA

Code

English

SAR-943

Code

English

Olcorolimus [WHO-DD]

Common Name

English

SAR943N

Code

English

Code System Code Type Description

ChEMBL

CHEMBL2103865