Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C51H81NO12 |
| Molecular Weight | 900.1883 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 15 / 15 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[H][C@@]12CC[C@@H](C)[C@@](O)(O1)C(=O)C(=O)N3CCCC[C@@]3([H])C(=O)O[C@@H](CC[C@H](C)\C=C(C)\[C@@H](O)[C@@H](OC)C(=O)[C@H](C)C[C@H](C)\C=C\C=C\C=C(C)\[C@H](C2)OC)[C@H](C)C[C@@H]4CC[C@@H](O)[C@@H](C4)OC
InChI
InChIKey=QFMKPDZCOKCBAQ-NFCVMBANSA-N
InChI=1S/C51H81NO12/c1-31-16-12-11-13-17-33(3)43(60-8)30-39-22-20-37(7)51(59,64-39)48(56)49(57)52-25-15-14-18-40(52)50(58)63-42(34(4)28-38-21-23-41(53)44(29-38)61-9)24-19-32(2)27-36(6)46(55)47(62-10)45(54)35(5)26-31/h11-13,16-17,27,31-32,34-35,37-44,46-47,53,55,59H,14-15,18-26,28-30H2,1-10H3/b13-11+,16-12+,33-17+,36-27+/t31-,32+,34-,35-,37-,38+,39+,40+,41-,42+,43+,44-,46-,47+,51-/m1/s1
| Molecular Formula | C51H81NO12 |
| Molecular Weight | 900.1883 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 15 / 15 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Olcorolimus (also known as SAR-943), a 32-deoxo rapamycin was developed as an immunosuppressant that can inhibit proliferation signal via interaction with the mammalian target of rapamycin. It was shown that this drug could have beneficial effect in patients with severe asthma. However, information about the current development of this drug is not available.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| In vivo and in vitro effects of SAR 943, a rapamycin analogue, on airway inflammation and remodeling. | 2003 Jan 15 |
|
| Structural identification of SAR-943 metabolites generated by human liver microsomes in vitro using mass spectrometry in combination with analysis of fragmentation patterns. | 2011 Jul |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 01:56:32 GMT 2023
by
admin
on
Sat Dec 16 01:56:32 GMT 2023
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| Record UNII |
IGL4DTS8F8
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Validated (UNII)
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CHEMBL2103865
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IGL4DTS8F8
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9450
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186752-78-3
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C170246
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XX-130
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CHEMBL3545142
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300000034269
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16663243
Created by
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