DEXFADROSTAT

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C14H13N3
Molecular Weight	223.2731
Optical Activity	( + )
Defined Stereocenters	1 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

N#CC1=CC=C(C=C1)[C@H]2CCCC3=CN=CN23

InChI

InChIKey=CLPFFLWZZBQMAO-CQSZACIVSA-N

InChI=1S/C14H13N3/c15-8-11-4-6-12(7-5-11)14-3-1-2-13-9-16-10-17(13)14/h4-7,9-10,14H,1-3H2/t14-/m1/s1

HIDE SMILES / InChI

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/22275532 | https://www.ncbi.nlm.nih.gov/pubmed/20699715 | https://www.ncbi.nlm.nih.gov/pubmed/27481775

(+)-Fadrozole (FAD-286) is an aldosterone synthase inhibitor. The drug was tested in vivo in preclinical models of hypertension, heart failure and was shown to reduce retinal neovascularization in rats with oxygen-induced retinopathy.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Cytochrome P450 11B2, mitochondrial 3 Target ID: P19099 Gene ID: 1585.0 Gene Symbol: CYP11B2 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/20699715	Inhibitor 8297		3.0 nM [IC50]

Conditions

Condition	Modality	Highest Phase	Product
Congestive heart failure 54 Sources: https://www.ncbi.nlm.nih.gov/pubmed/18586661	Primary	Preclinical	Unknown Approved Use Unknown
Hypertension 567 Sources: https://www.ncbi.nlm.nih.gov/pubmed/16685215	Primary	Preclinical	Unknown Approved Use Unknown
Neovascular retinopathy 3 Sources: https://www.ncbi.nlm.nih.gov/pubmed/22275532	Primary	Preclinical	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
Aldosterone synthase inhibitor ameliorates angiotensin II-induced organ damage.	2005 Jun 14	15939810
Investigation of aldosterone-synthase inhibition in rats.	2006 Jun	16685215

Sample Use Guides

In Vivo Use Guide

In a preclinical study, (+)-fadrozole was given to rats at a dose of 30 mg/kg.

Route of Administration: Other

In Vitro Use Guide

(+)-Fadrozole inhibited angiotensin II-stimulated basal aldosterone production in NCI-H295R cells, showing a maximal effect at 10 nmol/l.

Name

Type

Language

DEXFADROSTAT

Official Name

English

FADROZOLE, (R)-

Common Name

English

4-((5R)-5,6,7,8-TETRAHYDROIMIDAZO(1,5-A)PYRIDIN-5-YL)BENZONITRILE

Systematic Name

English

BENZONITRILE, 4-(5,6,7,8-TETRAHYDROIMIDAZO(1,5-A)PYRIDIN-5-YL)-, (R)-

Systematic Name

English

dexfadrostat [INN]

Common Name

English

(+)-FADROZOLE

Common Name

English

BENZONITRILE, 4-((5R)-5,6,7,8-TETRAHYDROIMIDAZO(1,5-A)PYRIDIN-5-YL)-

Systematic Name

English

Code System Code Type Description

CAS

102676-87-9