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Details

Stereochemistry ABSOLUTE
Molecular Formula C14H13N3.ClH
Molecular Weight 259.734
Optical Activity UNSPECIFIED
Defined Stereocenters 1 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of DEXFADROSTAT HYDROCHLORIDE

SMILES

Cl.N#CC1=CC=C(C=C1)[C@H]2CCCC3=CN=CN23

InChI

InChIKey=UKCVAQGKEOJTSR-PFEQFJNWSA-N
InChI=1S/C14H13N3.ClH/c15-8-11-4-6-12(7-5-11)14-3-1-2-13-9-16-10-17(13)14;/h4-7,9-10,14H,1-3H2;1H/t14-;/m1./s1

HIDE SMILES / InChI
Molecular Formula C14H13N3
Molecular Weight 223.2731
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 1 / 1
E/Z Centers 0
Optical Activity UNSPECIFIED
Molecular Formula ClH
Molecular Weight 36.461
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

(+)-Fadrozole (FAD-286) is an aldosterone synthase inhibitor. The drug was tested in vivo in preclinical models of hypertension, heart failure and was shown to reduce retinal neovascularization in rats with oxygen-induced retinopathy.

Approval Year

Unknown
149124
Targets

Targets

Primary TargetPharmacologyConditionPotency
Cytochrome P450 11B2, mitochondrial
3
Target ID: P19099
Gene ID: 1585.0
Gene Symbol: CYP11B2
Target Organism: Homo sapiens (Human)
Inhibitor
8504
 3.0 nM [IC50]
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Preclinical
Unknown

Approved Use

Unknown
Primary
Preclinical
Unknown

Approved Use

Unknown
Primary
Preclinical
Unknown

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
Investigation of aldosterone-synthase inhibition in rats.
2006-06
Aldosterone synthase inhibitor ameliorates angiotensin II-induced organ damage.
2005-06-14

Sample Use Guides

In Vivo Use Guide
In a preclinical study, (+)-fadrozole was given to rats at a dose of 30 mg/kg.
Route of Administration: Other
In Vitro Use Guide
(+)-Fadrozole inhibited angiotensin II-stimulated basal aldosterone production in NCI-H295R cells, showing a maximal effect at 10 nmol/l.
Substance Class Chemical
Created
by admin
on Mon Mar 31 23:38:16 GMT 2025
Edited
by admin
on Mon Mar 31 23:38:16 GMT 2025
Record UNII
6T3TZF5EG8
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
FAD-286
Preferred Name English
DEXFADROSTAT HYDROCHLORIDE
Common Name English
BENZONITRILE, 4-((5R)-5,6,7,8-TETRAHYDROIMIDAZO(1,5-A)PYRIDIN-5-YL)-, HYDROCHLORIDE (1:1)
Systematic Name English
BENZONITRILE, 4-((5R)-5,6,7,8-TETRAHYDROIMIDAZO(1,5-A)PYRIDIN-5-YL)-, MONOHYDROCHLORIDE
Common Name English
BENZONITRILE, 4-(5,6,7,8-TETRAHYDROIMIDAZO(1,5-A)PYRIDIN-5-YL)-, MONOHYDROCHLORIDE, (R)-
Common Name English
(+)-FADROZOLE HYDROCHLORIDE
Common Name English
FADROZOLE HYDROCHLORIDE, (R)-
Common Name English
Code System Code Type Description
FDA UNII
6T3TZF5EG8
Created by admin on Mon Mar 31 23:38:16 GMT 2025 , Edited by admin on Mon Mar 31 23:38:16 GMT 2025
PRIMARY
CAS
131863-75-7
Created by admin on Mon Mar 31 23:38:16 GMT 2025 , Edited by admin on Mon Mar 31 23:38:16 GMT 2025
PRIMARY
NCI_THESAURUS
C206682
Created by admin on Mon Mar 31 23:38:16 GMT 2025 , Edited by admin on Mon Mar 31 23:38:16 GMT 2025
PRIMARY
PUBCHEM
9838063
Created by admin on Mon Mar 31 23:38:16 GMT 2025 , Edited by admin on Mon Mar 31 23:38:16 GMT 2025
PRIMARY
Related Record Type Details
Structure of DEXFADROSTAT
PARENT -> SALT/SOLVATE
Related Record Type Details
Structure of DEXFADROSTAT
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