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Details

Stereochemistry ABSOLUTE
Molecular Formula C14H13N3.ClH
Molecular Weight 259.734
Optical Activity UNSPECIFIED
Defined Stereocenters 1 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of DEXFADROSTAT HYDROCHLORIDE

SMILES

Cl.N#CC1=CC=C(C=C1)[C@H]2CCCC3=CN=CN23

InChI

InChIKey=UKCVAQGKEOJTSR-PFEQFJNWSA-N
InChI=1S/C14H13N3.ClH/c15-8-11-4-6-12(7-5-11)14-3-1-2-13-9-16-10-17(13)14;/h4-7,9-10,14H,1-3H2;1H/t14-;/m1./s1

HIDE SMILES / InChI
Molecular Formula ClH
Molecular Weight 36.461
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE
Molecular Formula C14H13N3
Molecular Weight 223.2731
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 1 / 1
E/Z Centers 0
Optical Activity UNSPECIFIED

Description

(+)-Fadrozole (FAD-286) is an aldosterone synthase inhibitor. The drug was tested in vivo in preclinical models of hypertension, heart failure and was shown to reduce retinal neovascularization in rats with oxygen-induced retinopathy.

Approval Year

Unknown
139594
Targets

Targets

Primary TargetPharmacologyConditionPotency
Cytochrome P450 11B2, mitochondrial
3
Target ID: P19099
Gene ID: 1585.0
Gene Symbol: CYP11B2
Target Organism: Homo sapiens (Human)
Inhibitor
8297
 3.0 nM [IC50]
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Preclinical
Unknown

Approved Use

Unknown
Primary
Preclinical
Unknown

Approved Use

Unknown
Primary
Preclinical
Unknown

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
Aldosterone synthase inhibitor ameliorates angiotensin II-induced organ damage.
2005 Jun 14
Investigation of aldosterone-synthase inhibition in rats.
2006 Jun

Sample Use Guides

In Vivo Use Guide
In a preclinical study, (+)-fadrozole was given to rats at a dose of 30 mg/kg.
Route of Administration: Other
In Vitro Use Guide
(+)-Fadrozole inhibited angiotensin II-stimulated basal aldosterone production in NCI-H295R cells, showing a maximal effect at 10 nmol/l.
Substance Class Chemical
Created
by admin
on Sat Dec 16 11:05:37 GMT 2023
Edited
by admin
on Sat Dec 16 11:05:37 GMT 2023
Record UNII
6T3TZF5EG8
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
DEXFADROSTAT HYDROCHLORIDE
Common Name English
FAD-286
Code English
BENZONITRILE, 4-((5R)-5,6,7,8-TETRAHYDROIMIDAZO(1,5-A)PYRIDIN-5-YL)-, HYDROCHLORIDE (1:1)
Systematic Name English
BENZONITRILE, 4-((5R)-5,6,7,8-TETRAHYDROIMIDAZO(1,5-A)PYRIDIN-5-YL)-, MONOHYDROCHLORIDE
Common Name English
BENZONITRILE, 4-(5,6,7,8-TETRAHYDROIMIDAZO(1,5-A)PYRIDIN-5-YL)-, MONOHYDROCHLORIDE, (R)-
Common Name English
(+)-FADROZOLE HYDROCHLORIDE
Common Name English
FADROZOLE HYDROCHLORIDE, (R)-
Common Name English
Code System Code Type Description
FDA UNII
6T3TZF5EG8
Created by admin on Sat Dec 16 11:05:37 GMT 2023 , Edited by admin on Sat Dec 16 11:05:37 GMT 2023
PRIMARY
CAS
131863-75-7
Created by admin on Sat Dec 16 11:05:37 GMT 2023 , Edited by admin on Sat Dec 16 11:05:37 GMT 2023
PRIMARY
PUBCHEM
9838063
Created by admin on Sat Dec 16 11:05:37 GMT 2023 , Edited by admin on Sat Dec 16 11:05:37 GMT 2023
PRIMARY
Related Record Type Details
Structure of DEXFADROSTAT
PARENT -> SALT/SOLVATE
Related Record Type Details
Structure of DEXFADROSTAT
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