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Details

Stereochemistry ABSOLUTE
Molecular Formula C22H34N2O2.ClH
Molecular Weight 394.979
Optical Activity UNSPECIFIED
Defined Stereocenters 2 / 2
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of IPENOXAZONE HYDROCHLORIDE

SMILES

Cl.CC(C)C[C@H]1[C@H](OC(=O)N1CCCN2CCCCCC2)C3=CC=CC=C3

InChI

InChIKey=WXDRKSLHMGNBSF-JUDYQFGCSA-N
InChI=1S/C22H34N2O2.ClH/c1-18(2)17-20-21(19-11-6-5-7-12-19)26-22(25)24(20)16-10-15-23-13-8-3-4-9-14-23;/h5-7,11-12,18,20-21H,3-4,8-10,13-17H2,1-2H3;1H/t20-,21+;/m0./s1

HIDE SMILES / InChI

Description

Ipenoxazone (NC 1200) is a muscle relaxant that is under investigation (phase II) for the treatment of Alzheimer's Dementia, Cognition Disorders. It acts as an Ionotropic glutamate receptor antagonist.

Originator

Approval Year

Unknown
149124
Targets

Targets

Primary TargetPharmacologyConditionPotency
Antagonist
2849
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Phase II
1147
Unknown

Approved Use

Unknown
Primary
Phase II
1147
Unknown

Approved Use

Unknown
Sourcing

Sourcing

Vendor/AggregatorIDURL
Compound Cloud
13713369
Compound Cloud
65882
MuseChem
M008767
https://www.musechem.com/product/M008767.html
Toronto Research Chemicals
I739445
https://www.trc-canada.com/product-detail/?CatNum=I739445
PubMed

PubMed

TitleDatePubMed
Pharmacological properties of a new centrally acting muscle relaxant (NC-1200) in isolated muscle preparations.
1988
Patents

Patents

US2016024088
2

Sample Use Guides

In Vivo Use Guide
Unknown
Route of Administration: Unknown
In Vitro Use Guide
NC-1200 (IPENOXAZONE) acted as a Ca-blocker in the guinea pig taenia caecum. The pA2-value was 5.67
Name Type Language
IPENOXAZONE HYDROCHLORIDE
JAN  
Common Name English
2-OXAZOLIDINONE, 3-(3-(HEXAHYDRO-1H-AZEPIN-1-YL)PROPYL)-4-(2-METHYLPROPYL)-5-PHENYL-, MONOHYDROCHLORIDE, (4S,5R)-
Preferred Name English
2-OXAZOLIDINONE, 3-(3-(HEXAHYDRO-1H-AZEPIN-1-YL)PROPYL)-4-(2-METHYLPROPYL)-5-PHENYL-, MONOHYDROCHLORIDE, (4S-CIS)-
Common Name English
IPENOXAZONE MONOHYDROCHLORIDE
Common Name English
IPENOXAZONE HYDROCHLORIDE [JAN]
Common Name English
Code System Code Type Description
EPA CompTox
DTXSID5057626
Created by admin on Mon Mar 31 21:41:05 GMT 2025 , Edited by admin on Mon Mar 31 21:41:05 GMT 2025
PRIMARY
FDA UNII
I9OAW9Y451
Created by admin on Mon Mar 31 21:41:05 GMT 2025 , Edited by admin on Mon Mar 31 21:41:05 GMT 2025
PRIMARY
CAS
118635-68-0
Created by admin on Mon Mar 31 21:41:05 GMT 2025 , Edited by admin on Mon Mar 31 21:41:05 GMT 2025
PRIMARY
PUBCHEM
13713369
Created by admin on Mon Mar 31 21:41:05 GMT 2025 , Edited by admin on Mon Mar 31 21:41:05 GMT 2025
PRIMARY
ACTIVE MOIETY
Structure of IPENOXAZONE
NIH
NCATS
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