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Details

Stereochemistry ABSOLUTE
Molecular Formula C22H34N2O2.ClH
Molecular Weight 394.979
Optical Activity UNSPECIFIED
Defined Stereocenters 2 / 2
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of IPENOXAZONE HYDROCHLORIDE

SMILES

Cl.CC(C)C[C@H]1[C@H](OC(=O)N1CCCN2CCCCCC2)C3=CC=CC=C3

InChI

InChIKey=WXDRKSLHMGNBSF-JUDYQFGCSA-N
InChI=1S/C22H34N2O2.ClH/c1-18(2)17-20-21(19-11-6-5-7-12-19)26-22(25)24(20)16-10-15-23-13-8-3-4-9-14-23;/h5-7,11-12,18,20-21H,3-4,8-10,13-17H2,1-2H3;1H/t20-,21+;/m0./s1

HIDE SMILES / InChI
Molecular Formula C22H34N2O2
Molecular Weight 358.5176
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 2 / 2
E/Z Centers 0
Optical Activity UNSPECIFIED
Molecular Formula ClH
Molecular Weight 36.461
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Ipenoxazone (NC 1200) is a muscle relaxant that is under investigation (phase II) for the treatment of Alzheimer's Dementia, Cognition Disorders. It acts as an Ionotropic glutamate receptor antagonist.

Originator

Approval Year

Unknown
139594
Targets

Targets

Primary TargetPharmacologyConditionPotency
Antagonist
2778
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Phase II
1132
Unknown

Approved Use

Unknown
Primary
Phase II
1132
Unknown

Approved Use

Unknown
Sourcing

Sourcing

Vendor/AggregatorIDURL
Compound Cloud
13713369
Compound Cloud
65882
MuseChem
M008767
https://www.musechem.com/product/M008767.html
Toronto Research Chemicals
I739445
https://www.trc-canada.com/product-detail/?CatNum=I739445
PubMed

PubMed

TitleDatePubMed
Pharmacological properties of a new centrally acting muscle relaxant (NC-1200) in isolated muscle preparations.
1988
Patents

Patents

US2016024088
2

Sample Use Guides

In Vivo Use Guide
Unknown
Route of Administration: Unknown
In Vitro Use Guide
NC-1200 (IPENOXAZONE) acted as a Ca-blocker in the guinea pig taenia caecum. The pA2-value was 5.67
Substance Class Chemical
Created
by admin
on Sat Dec 16 07:15:26 GMT 2023
Edited
by admin
on Sat Dec 16 07:15:26 GMT 2023
Record UNII
I9OAW9Y451
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
IPENOXAZONE HYDROCHLORIDE
JAN  
Common Name English
2-OXAZOLIDINONE, 3-(3-(HEXAHYDRO-1H-AZEPIN-1-YL)PROPYL)-4-(2-METHYLPROPYL)-5-PHENYL-, MONOHYDROCHLORIDE, (4S-CIS)-
Common Name English
2-OXAZOLIDINONE, 3-(3-(HEXAHYDRO-1H-AZEPIN-1-YL)PROPYL)-4-(2-METHYLPROPYL)-5-PHENYL-, MONOHYDROCHLORIDE, (4S,5R)-
Common Name English
IPENOXAZONE MONOHYDROCHLORIDE
Common Name English
IPENOXAZONE HYDROCHLORIDE [JAN]
Common Name English
Code System Code Type Description
EPA CompTox
DTXSID5057626
Created by admin on Sat Dec 16 07:15:26 GMT 2023 , Edited by admin on Sat Dec 16 07:15:26 GMT 2023
PRIMARY
FDA UNII
I9OAW9Y451
Created by admin on Sat Dec 16 07:15:26 GMT 2023 , Edited by admin on Sat Dec 16 07:15:26 GMT 2023
PRIMARY
CAS
118635-68-0
Created by admin on Sat Dec 16 07:15:26 GMT 2023 , Edited by admin on Sat Dec 16 07:15:26 GMT 2023
PRIMARY
PUBCHEM
13713369
Created by admin on Sat Dec 16 07:15:26 GMT 2023 , Edited by admin on Sat Dec 16 07:15:26 GMT 2023
PRIMARY
Related Record Type Details
Structure of IPENOXAZONE
PARENT -> SALT/SOLVATE
Related Record Type Details
Structure of IPENOXAZONE
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