CUPRIC SALICYLATE

Details

Stereochemistry	ACHIRAL
Molecular Formula	2C7H5O3.Cu
Molecular Weight	337.772
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[Cu++].OC1=C(C=CC=C1)C([O-])=O.OC2=C(C=CC=C2)C([O-])=O

InChI

InChIKey=CMRVDFLZXRTMTH-UHFFFAOYSA-L

InChI=1S/2C7H6O3.Cu/c2*8-6-4-2-1-3-5(6)7(9)10;/h2*1-4,8H,(H,9,10);/q;;+2/p-2

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Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/367963

Cupric salicylate is an anti-inflammatory agent which was used as pain relief for patients with osteoarthritis, rheumatoid and other degenerative diseases (as a copper-salicylate complex). The preparation seem to be discontinued for now.

CNS Activity

Originator

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Rheumatic diseases 31 Sources: https://www.ncbi.nlm.nih.gov/pubmed/367963	Palliative		Approved 8583	PERMALON Approved Use Unknown

PubMed

Title	Date	PubMed
The effect of ionic strength on the complexation of copper (II) with salicylate ion.	2002-07-20	12125457
Copper-salicylate gel for pain relief in osteoarthritis: a randomised controlled trial.	1997-08-04	9269267
Copper salicylate as an anti-inflammatory and analgesic agent in arthritic rats.	1983-02-28	6600809
Treatment of rheumatoid and degenerative diseases with copper complexes: a review with emphasis on copper-salicylate.	1977-09	367963

Patents

Sample Use Guides

In Vivo Use Guide

Cupric salicylate gel (1.5 g) was applied twice daily to the forearm for four weeks. Cupric salicylate also was given as 6 and 8 intravenous infusions (60-80 mg of copper, Permalon preparation) every 3-4 days.

Route of Administration: Other

In Vitro Use Guide

Unknown

Name

Type

Language

CUPRIC SALICYLATE

Common Name

English

2-HYDROXYBENZOIC ACID COPPER SALT

Preferred Name

English

Copper salicylate [WHO-DD]

Common Name

English

BIS(2-(HYDROXY-.KAPPA.O)BENZOATO-.KAPPA.O)COPPER

Common Name

English

BENZOIC ACID, 2-HYDROXY-, COPPER(2+) SALT

Common Name

English

COPPER(II) SALICYLATE

Systematic Name

English

COPPER, BIS(2-HYDROXYBENZOATO-O1,O2)-

Common Name

English

COPPER DISALICYLATE

Systematic Name

English

COPPER(2+) SALICYLATE

Systematic Name

English

CUPRIC O-HYDROXYBENZOATE

Common Name

English

CUPRIC SALICYLATE [MI]

Common Name

English

Code System Code Type Description

FDA UNII

I11SQ4NX1R